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| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | The ecology of the European rabbit (Oyctolagus cuniculus) in coastal southwestern Australia显示文摘 | Twigg L E Lowe T J Martin G R | 1998 | Wildl Res1998，25，： | 1 |
| 3 | An Investigation of the Plastic Fracture of AISI 4340 and 18Nickel -200 Grade Maraging Steels 显示文摘 | Cox T B Low J R | 1974 | Metallurgical Transac- tions1974，5，6： | 1 |
| 4 | Thermal cycling analysis of flip-chip solder joint reliability 显示文摘 | Pang J H L Chong D Y R Low T H | 2001 | Components and Packaging Technologies2001，24，4： | 1 |
| 5 | Predictive value of electronic fetal monitoring for intrapartum fetal asphyxia with metabolic acidosis显示文摘 | Low J A Victory R Derrick E J | 1999 | Obstet Gynecol1999，93，2： | 1 |
| 6 | Rationalizing the Activities of Diverse Cholecystokinin 2 Receptor Antagonists Using Molecular Field Points显示文摘 | Low C M R Vinter J G | 2008 | J Med Chem2008，51，3： | 1 |
| 7 | 显示文摘 | HALTIWANGER R S LOWE J B | 2004 | Annu Rev Biochem2004，73，： | 1 |
| 8 | Folate receptor-mediated targeting of liposomal drugs to cancer cells显示文摘 | STEPHENSON S M LOW P S LEE R J | 2004 | Methods Enzymol2004，387，： | 1 |
| 9 | Folate - mediated tumor cell targeting of lipo- some- entrapped doxorubicin in vitro 显示文摘 | Lee R J Low P S | 1995 | Biochim Biophys Acta1995，1233，： | 1 |
| 10 | An algorithm for abdominal wall reconstruction 显示文摘 | Rohrich R J Lowe JB Hackney FL | 2000 | Plast Reconstr Surg2000，105，1： | 1 |
| 11 | A simple method of measuring gradient induced eddy currents to set compensation networks显示文摘 | Wysong R E Lowe I J | 1993 | Magn Reson Med1993，29，： | 1 |
| 12 | Electrodeposition of composite coatings containing nanoparticles in a metal deposit显示文摘 | LOW C T J WILLS R G A WALSH F C | 2006 | Surface & Coatings Technology2006，201，： | 1 |
| 13 | Gene expression analysis by transcript profiling coupled to a gene database query 显示文摘 | Shimkets R A Lowe D G Tai J T | 1999 | Nat Biotechnol1999，17，8： | 1 |
| 14 | Cytokeratin 20 in human carcinomas: a new histodiagnositic marker显示文摘 | Moll R Lowe A Laufer J | 1992 | Am J Pathol1992，140，： | 1 |
| 15 | Cytokeratin 20 in human carcinomas:a new histodiagnostic marker detected by monoclonal antibodies显示文摘 | Moll R Lowe A Laufer J | 1992 | Am J Pathol1992，140，2： | 1 |
| 16 | Antigenic diversity and similarities detected in avian paramyxovirus type 1 (Newcastle disease virus) isolates using monoclonal antibod- ies显示文摘 | Alexander D J Manvell R J Lowings J P | 1997 | Avian Pathol1997，26，2： | 1 |
| 17 | Beamforming matrix simplifies design of electronically scanned antennas 显示文摘 | Butler J Lowe R | 1961 | Electronic Design1961，9，17： | 1 |
| 18 | Folate-mediated tumor cell targeting of liposome-entrapped doxorubicin in vitro显示文摘 | Lee R J Low P S | | 0，，02： | 1 |
| 19 | Monitoring acoustic wave propagation in buried cast iron water pipes显示文摘 | Long R Vine K Lowe M J S | | Review of Progress in Quantitative Nondestructive Evaluation0，200，20： | 1 |
| 20 | An algorithm for abdominal wall reconstruction 显示文摘 | Rohrich R J Lowe JB Hackney FL | 2000 | Plast Reconstr Surg2000，105，1： | 1 |
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