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| 1 | 胚胎巨噬细胞和小胶质细胞消融调控小鼠胚胎背根神经节感觉神经元的发育显示文摘众所周知,小胶质细胞可以调节中枢神经系统发育的一些方面。在第11.5天的小鼠胚胎中的小胶质细胞定殖脊髓时,它们与背根神经节感觉神经元(SN)的生长中心轴突相互作用,这表明它们可能在SN发育中发挥一定功能。为了解决这个问题,我们使用缺乏胚胎巨噬细胞(PU.1敲除小鼠)和免疫细胞消融的小鼠胚胎分析胚胎巨噬细胞消融对SNs早期发育的影响。我们发现,除小胶质细胞外,胚胎巨噬细胞还与来自第11.5天的小鼠胚胎的原肌球蛋白受体激酶(Trk)C+感觉神经元,TrkB+感觉神经元和TrkA+感觉神经元外周神经突产生交联。免疫细胞剥夺会导致第11.5天的小鼠胚胎的TrkC+感觉神经元和TrkB+感觉神经元初始数量的减少,这与其发育细胞死亡(DCD)的改变有关联的可能性较小,因为其后在第12.5天的胚胎中的数量有短暂增加。在分析的发育期(第11.5~15.5天),它也导致TrkA+感觉神经元数量减少,尽管我们没有观察到他们的DCD有任何变化。与神经元祖细胞可能存在一致性的脑脂肪酸结合蛋白(BFABP-)阴性细胞的增殖在第11.5天的胚胎中增加,而它们的增殖在第12.5天的胚胎减少,这可部分解释从11.5 d观察到的SN亚型产生的改变。此外,我们观察到在缺乏胚胎巨噬细胞的情况下神经胶质细胞祖细胞(BFABP+细胞)增殖的改变。我们的数据表明,胚胎巨噬细胞和小胶质细胞消融调控SN的发育。 | Angelim MKSC Maia LMSS Mouffle C Ginhoux F Low D Amancio-Dos-Santos A Makhoul J Le Corronc H Mangin JM Legendre P 聂昊(编译) | 2018 | 神经损伤与功能重建2018，13，9： | 2 |
| 2 | The Elongator subunit Elp3 contains a Fe4S4 cluster and binds S-adenosylmethionine显示文摘 | Paraskevopoulou C Fairhurst S A Lowe D J | 2006 | Mol Microbiol2006，59，3： | 1 |
| 3 | Invasive infection due to Streptococcus iniae: a new or previously unrecognized disease显示文摘 | WEINSTEIN M R LOW D E McGeer A | 1996 | Ontario CCDR1996，22，： | 1 |
| 4 | Facial morphology and obstructive sleep apnea显示文摘 | Lowe A A Santamaria J D Fleetham J A | | 0，，6： | 1 |
| 5 | Chronology of Early Archean granite-greenstone evolution in the Barberton Mountain Land, South Africa, based on precise dating by single zircon evaporation 显示文摘 | Kr6ner A Byerly G R Lowe D R | 1991 | Earth and Planetary Science Letters1991，103，14： | 1 |
| 6 | Oxidative injury and apoptosis of dorsal ganglion neurons in chronic experimental diabetic neuropathy显示文摘 | Schmeichel A M Schmeizer J D Low P A | 2003 | Diabetes2003，52，： | 1 |
| 7 | Discovery and development of folic-acid-based receptor targeting for imaging and therapy of cancer and inflammatory diseases 显示文摘 | LOW P S HENNE W A DOORNEWEERD D D | 2008 | Acc Chem Res2008，41，： | 1 |
| 8 | The relative importance of non-sea-salt sulphate and sea-salt aerosol to the marine cloud condensation nuclei population:Animproved multi-component aerosol-cloud droplet parametrization显示文摘 | O'Dowd C D Lowe J A Smith M H | 1999 | Quart J Roy Meteor Soc1999，125，556： | 1 |
| 9 | Severe tissue damage in Atlantic cod larvae under increasing ocean acidification显示文摘 | Frommel A Y Maneja R Lowe D | 2012 | Nature Climate Change2012，2，1： | 1 |
| 10 | Acute upper gastrointestinal bleeding in the UK:patient characteristics,diagnoses and outcomes in the 2007 UK audit显示文摘 | Hearnshaw S A Logan R F Lowe D | 2011 | Gut2011，60，10： | 1 |
| 11 | Anessentiat role for A adeninemet hylation in bacterial virulence显示文摘 | Heithoff D M Sinsheimer R L Low D A | 2000 | Trans R Soc Lond B Biol Sci2000，355，1397： | 1 |
| 12 | Chemical and Mechanical Properties of Vinyl-ester/ABS Blends显示文摘 | Stevanovic D Low A Kalyanasundaram S | 2002 | Polymer2002，43，： | 1 |
| 13 | Determination of the isotopic composition of atmospheric methane and its application in the Antarctic显示文摘 | Lowe D C Brenninkmeijer C A M Tyler S C | 1991 | Journal of Geophysical Research1991，96，15： | 1 |
| 14 | Relation between extent of coronary artery disease and blood viscosity显示文摘 | LOWE G D DRUMMOND M M LORIMER A R | 1980 | Br Med J1980，280，3： | 1 |
| 15 | A technique for the quanti- tative evaluation of dose distributions显示文摘 | LOW D A HARMS W B MUTIC S | 1998 | Medical Physics1998，30，5： | 1 |
| 16 | The Effects of Internal Audit Outsourcing on Perceived External Auditor Independence 显示文摘 | Lowe D J Geiger M A Pany K | 1999 | Auditing: A Journal of Practice & Theory1999，18，： | 1 |
| 17 | FactorⅧ, VonWillebrand factor and the risk of major ischernic heart disease in the carephilly heart study显示文摘 | RUMLEY A LOWE G D O SWEETNAM P M | 1999 | Br J Haematol1999，105，1： | 1 |
| 18 | Gene expression analysis by transcript profiling coupled to a gene database query 显示文摘 | Shimkets R A Lowe D G Tai J T | 1999 | Nat Biotechnol1999，17，8： | 1 |
| 19 | Interleukin-6 -174G>C polymorphism and risk of coronary heart disease in West of Scotland coronary prevention study (WOSCOPS)显示文摘 | BASSO F LOWE G D RUMLEY A | 2002 | Arterioscler Thromb Vasc Biol2002，22，： | 1 |
| 20 | Are overconfident CEOs better innovators显示文摘 | HIRSHLEIFER D LOW A TEOH S H | 2012 | The Journal of Finance2012，67，4： | 1 |
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