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| 1 | Osteopontin as potential biomarker and therapeutic target in gastric and liver cancers显示文摘Gastric cancer and liver cancer are among the most common malignancies and the leading causes of death worldwide,due to late detection and high recurrence rates.Today,these cancers have a heavy socioeconomic burden,for which a full understanding of their pathophysiological features is warranted to search for promising biomarkers and therapeutic targets.Osteopontin (OPN) is overexpressed in most patients with gastric and liver cancers.Over the past decade,emerging evidence has revealed a correlation of OPN level and clinicopathological features and prognosis in gastric and liver cancers,indicating its potential as an independent prognostic indicator in such patients.Functional studies have verified the potential of OPN knockdown as a therapeutic approach in vitro and in vivo .Furthermore,OPN mediates multifaceted roles in the interaction between cancer cells and the tumor microenvironment,in which many details need further exploration.OPN signaling results in various functions,including prevention of apoptosis,modulation of angiogenesis,malfunction of tumor-associated macrophages,degradation of extracellular matrix,activation of phosphoinositide 3-kinase-Akt and nuclear factor-κB pathways,which lead to tumor formation and progression,particularly in gastric and liver cancers.This editorial aims to review recent findings on alteration in OPN expression and its clinicopathological associations with tumor progression,its potential as a therapeutic target,and putative mechanisms in gastric and liver cancers.Better understanding of the implications of OPN in tumorigenesis might facilitate development of therapeutic regimens to benefit patients with these deadly malignancies. | Dong-Xing Cao Zhi-Jie Li Xiao-Ou Jiang Yick Liang Lum Ester Khin Nikki P Lee Guo-Hao Wu John M Luk | 2012 | World Journal of Gastroenterology2012，18，30： | 29 |
| 2 | Optimization of a Spherical Mechanism for a Minimally Invasive Surgical Robot Theoretical and Experimental Approaches 显示文摘 | LUM M J H etc | 2006 | IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING2006，53，7： | 1 |
| 3 | Growth factor regula- tion of autophagy and cell survival in the absence of apop- tosis显示文摘 | Lum JJ Bauer DE Kong M | 2005 | Cell2005，120，2： | 1 |
| 4 | A before-and-after study on green signal countdown device installation 显示文摘 | Lum K M Halim H | 2006 | Transportation Research Part F2006，9，： | 1 |
| 5 | The impact of the ratio of positive to total lymph nodes examined and out- come in colorectal cancer 显示文摘 | Ng M Roy-Chowdhury S Lum SS | 2009 | Am Surg2009，75，10： | 1 |
| 6 | Planning and control of a biped robot 显示文摘 | Lum H K Zribi M Soh Y C | 1999 | International Journal of Engineering Science1999，37，： | 1 |
| 7 | The biology and treatment of superficial bladder cancer显示文摘 | Torti F M Lum B L | 1984 | J Clin Oncol1984，2，5： | 1 |
| 8 | Method ofdelivery and pregnancy outcomes inAsia:theWHO global survey onmaternal and perinatal health显示文摘 | Lum biganon P Laopa iboon M Gulmezoglu AM | 2010 | The Lancet2010，375，9713： | 1 |
| 9 | Minimizing the risk of reporting false positives in large-scale RNAi screens显示文摘 | Echeverri C.J Beachy P.A Baum B Boutros M Buchholz F Chanda K K Downward J Ellenberg J Fraser A.G Hacohen N Hahn W.C Jackson A.L Kiger A Linsley P.S Lum L Ma Y Mathey-Prevot B Root D.E Sabatini D.M Taipale J Perrimon N and Bernards R | | 0，，： | 1 |
| 10 | Alteration of etoposide pharmacokinetics and pharmacodynamics by cyclosporine in a phase I trial to modulate multidrug resistance显示文摘 | Lum B L Kaubisch S Yahanda A M | 1992 | J Clin Oncol1992，10，10： | 1 |
| 11 | The biology and treatment of superficial bladder cancer 显示文摘 | Tortifm M Lum BL | 1984 | J Clin Oncol1984，2，： | 1 |
| 12 | Renal arteries iso tropic, high-spatial-resolution, unenhanced MR angiography with three dimensional radial phase contrast显示文摘 | Francois C J Lum D P Johnson K M | 2011 | Radiology2011，258，1： | 1 |
| 13 | Adaptive control allocation for non-linear systems with internal dynamics显示文摘 | F Liao K Y Lum J L Wang M Benosman | 2010 | Control Theory & Applications IET2010，4，6： | 1 |
| 14 | Xenotransplantation of microencapsulated fetal rat islets 显示文摘 | Krestow M Lum ZP Tai IT | 1991 | Transplantation1991，51，3： | 1 |
| 15 | Caregiving burden and quality of life of pneumoconiosis caregivers in Hong Kong 显示文摘 | TANG W K YIP W C LUM C M | 2011 | Heart Lung2011，40，5： | 1 |
| 16 | Growth Factor Regulation of Autophage and Cell Survival in the Absence of Apoptosis显示文摘 | Lum JJ Bawor DE Kong M | 2005 | Cell2005，120，2： | 1 |
| 17 | Growth factor regulation of autophagy and cell survival in the absence of apoptosis显示文摘 | Lum J J Bauer D E Kong M | 2005 | Cell2005，120，2： | 1 |
| 18 | Smoke Suppression by Metal Oxides in PVC显示文摘 | Edeleson D V J Kuck A Michel R M Lum | 1980 | Combust Flame1980，38，： | 1 |
| 19 | A before-and-after study on green signal countdown device installation 显示文摘 | LUM K M HALIM H | 2006 | Transportation Research Part F2006，9，1： | 1 |
| 20 | Growth factor regulation of autophagy and cell survival in the absence of apoptosis 显示文摘 | Lum JJ Bauer DE Kong M | 2005 | Cell2005，120，2： | 1 |
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