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| 1 | Abnormal activation of the synuclein-gamma gene in hepatocellular carcinomas by epigenetic alteration.显示文摘 | Zhao W Liu H Liu W Wu Y Chen W Jiang B Zhou Y Xue R Luo C Wang L Jiang JD Liu J | 2006 | 中国生物学文摘2006，20，4： | 31 |
| 2 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 3 | Terahertz Semiconductor Quantum Well Devices显示文摘For eventually providing terahertz science with compact and convenient devices,terahertz (1~10THz) quantum-well photodetectors and quantum-cascade lasers are investigated.The design and projected detector performance are presented together with experimental results for several test devices,all working at photon energies below and around optical phonons.Background limited infrared performance (BLIP) operations are observed for all samples (three in total),designed for different wavelengths.BLIP temperatures of 17,13,and 12K are achieved for peak detection frequencies of 9.7THz(31μm),5.4THz(56μm),and 3.2THz(93μm),respectively.A set of THz quantum-cascade lasers with identical device parameters except for doping concentration is studied.The δ-doping density for each period varies from 3.2×1010 to 4.8×1010cm-2.We observe that the lasing threshold current density increases monotonically with doping concentration.Moreover,the measurements for devices with different cavity lengths provide evidence that the free carrier absorption causes the waveguide loss also to increase monotonically.Interestingly the observed maximum lasing temperature is best at a doping density of 3.6×1010cm-2. | Liu H C Luo H Ban D Waichter M Song C Y Wasilewski Z R Buchanan M Aers G C SpringThorpe A J Cao J C Feng S L Williams B S Hu Q | 2006 | Journal of Semiconductors2006，27，4： | 2 |
| 4 | 纳米光子结构软膜紫外光固化纳米压印(英文)显示文摘紫外光固化纳米压印是实现纳米结构批量复制的一种新技术.其特点是低成本和高分辨,而且可以达到极高的套刻精度.为了得到大面积图案的均匀复制,可用聚二甲基硅氧烷(PDMS)制备透光的压印软模板.其母版图案可由高分辨率电子束曝光和反应离子刻蚀的方法在硅片基底上获得,然后用浇注的方法将图案转移到PDMS上.本实验特别发展了紫外光固化纳米压印适用于软膜压印的双层膜图型转移技术.该双层膜由廉价的光胶和聚甲基丙烯酸甲脂(PMMA)构成.对光胶层的压印可用普通的光学曝光仪实现.然后再将图案用反应离子刻蚀的方法转移到PMMA层中.为了证明方案的可行性,在两种不同材料的半导体基片上压印了三角晶格的光子晶体和准晶结构的图案,并用剥离的方法将它们转移到金属薄膜上,最后成功地进行了硅片刻蚀实验.相信这一纳米制做方法对大面积纳米光子结构和光学集成芯片的制造是普遍适用的. | SHI J WANG Z M BAO K PEROZ C BELOTTI M XU L P LUO C X SUN M H ZHANG B JI H OUYANG Q CHEN Y | 2006 | 纳米技术与精密工程2006，4，3： | 2 |
| 5 | Exogenous cytokinin application to Actinidia chinensis var. deliciosa ‘Hayward’ fruit promotes fruit expansion through water uptake显示文摘Exogenous application of a cytokinin-like compound forchlorfenuron(CPPU)can promote fruit growth,although often at the expense of dry matter(DM),an important indicator of fruit quality.Actinidia chinensis var.deliciosa‘Hayward’fruit are very responsive to CPPU treatments,but the mechanism underlying the significant fruit weight increase and associated decrease in DM is unclear.In this study,we hypothesised that CPPU-enhanced growth increases fruit carbohydrate demand,but limited carbohydrate supply resulted in decreased fruit DM.During fruit development,CPPU effects on physical parameters,metabolites,osmotic pressure and transcriptional changes were assessed under conditions of both standard and a high carbohydrate supply.We showed that CPPU increased fruit fresh weight but the dramatic DM decrease was not carbohydrate limited.Enhanced glucose and fructose concentrations contributed to an increase in soluble carbohydrate osmotic pressure,which was correlated with increased water accumulation in CPPU-treated fruit and up-regulation of water channel aquaporin gene PIP2.4 at 49 days after anthesis.Transcipt analysis suggested that the molecular mechanism contributing to increased glucose and fructose concentrations was altered by carbohydrate supply.At standard carbohydrate supply,the early glucose increase in CPPU fruit was associated with reduced starch synthesis and increased starch degradation.When carbohydrate supply was high,the early glucose increase in CPPU fruit was associated with a general decrease in starch synthesis but up-regulation of vacuolar invertase and fructokinase genes.We conclude that CPPU affected fruit expansion by increasing the osmotically-driven water uptake and its effect was not carbohydrate supply-limited. | Simona Nardozza Helen L Boldingh Mark W Wohlers Andrew P Gleave Zhiwei Luo Guglielmo Costa Elspeth A MacRae Michael J Clearwater Annette C Richardson | 2017 | Horticulture Research2017，4，1： | 2 |
| 6 | A polysaceharide isolated from the medicinal herb Bletilla striata induces endothelial cells proliferation and vascular endothelial growth factor expression in vitro 显示文摘 | WANG C M SUN J T LUO Y | 2006 | Biotechnol Lett2006，28，8： | 1 |
| 7 | A decision model for variety mixtures to control yellow rust on winter wheat 显示文摘 | LUO Y ZADOKS J C | 1992 | Agricultural Systems1992，38，1： | 1 |
| 8 | Epoxidation of propylene on NaCl-modified silver catalysts with air as the oxidant显示文摘 | Lu J Luo M Li C | 2002 | Appl Catal A: Gen2002，237，12： | 1 |
| 9 | Ultrasonic-template Method Synthesis of CdS Hollow Nanoparticle Chains显示文摘 | Liu J K Luo C X Yang X H | 2009 | Materials Letters2009，63，： | 1 |
| 10 | A comparative evalution of gin-senosides in commercial ginseng products and tissue culturesamples using HPLC显示文摘 | Ma Y C Zhu J Benkrima L Luo M Sun L H Sain S Kont K Plaut-Carcasson Y Y | 1996 | Journal of Herbs Spices&Me-dicinal Plants1996，3，4： | 1 |
| 11 | Topology optimization of structures with geometrical nonlinearities 显示文摘 | GEA H C LUO J H | 2001 | Comput & Struet2001，79，： | 1 |
| 12 | Biosensor for detection of hypoxanthine based on xanthine xidase immobilized on chemically modified carbon paste electrode 显示文摘 | Hu S S Xu C L Luo J H | 2000 | Analytica Chimica Acta2000，412，： | 1 |
| 13 | Power electronic hybrid system for load balancing compensation and frequency-selective harmonic suppression显示文摘 | Luo A Peng S J Wu C P | 2012 | IEEE Transactions on Industry Electronics2012，59，2： | 1 |
| 14 | An improved spectrophotometric method for a more specific and accurate assay of mitochondrial complex Ⅲ activity显示文摘 | Luo C Long J Liu J | 2008 | Clin Chim Aeta2008，395，12： | 1 |
| 15 | Selection of image features for steganalysis based on the Fisher criterion 显示文摘 | Lu J C Liu F L Luo X Y | 2014 | Digital In- vestigation2014，11，1： | 1 |
| 16 | Investigation of gene effects and epistatic interactions between Aktl and neuregulin 1 in the regula- tion of behavioral phenotypes and social functions in genetic mouse models of schizophrenia显示文摘 | Huang C Pei J Luo D | 2014 | Front Behav Neurosci2014，8，： | 1 |
| 17 | Silver phosphate crystal growth by screw dislocation driven of dynamic-template 显示文摘 | Wang J D Liu J K Luo C X Lu Y Yang X H | 2013 | Crystal Growth & Design2013，13，11： | 1 |
| 18 | Loss of ARF sensitizes transgenic BRAFV600E mice to UV- induced melanoma via suppression of XPC显示文摘 | Luo C Sheng J Hu MG | 2013 | Cancer Res2013，73，14： | 1 |
| 19 | The role of the western Arabian Sea upwelling in Indian monsoon rainfall variability显示文摘 | Izumo T Montegut C B Luo J J | 2008 | J Climate2008，21，： | 1 |
| 20 | Diffusion dialysis of hydrochloride acid at different temperatures using PPO/SiO2 hybrid anion exchange membranes 显示文摘 | Luo J Y Wu C M Wu Y H | 2010 | J Membr Sci2010，347，12： | 1 |
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