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| 1 | Duodenal gangliocytic paraganglioma with lymph node metastases: a case report and comparative review of 31 cases显示文摘Gangliocytic paraganglioma(GP) is a rare tumor of uncertain origin most often located in the second portion of the duodenum. It is composed of three cellular components: Epithelioid endocrine cells, spindlelike/sustentacular cells, and ganglion-like cells. While this tumor most often behaves in a benign manner, cases with metastasis are reported. We describe the case of a 62-year-old male with a periampullary GP with metastases to two regional lymph nodes who was successfully treated with pancreaticoduodenectomy. Using Pub Med, EMBASE, EBSCOhost MEDLINE and CINAHL, and Google Scholar, we searched the literature for cases of GP with regional lymph node metastasis and evaluated the varying presentations, diagnostic workup, and disease management of identified cases. Thirty-one cases of GP with metastasis were compiled(30 with at least lymph node metastases and one with only distant metastasis to bone), with age at diagnosis ranging from 16 to 74 years. Ratio of males to females was 19:12. The most common presenting symptoms were abdominal pain(55%) and gastrointestinal bleeding or sequelae(42%). Twenty-five patients underwent pancreaticoduodenectomy. Five patients were treated with local resection alone. One patient died secondary to metastatic disease, and one died secondary to perioperative decompensation. The remainder did well, with no evidence of disease at follow-up from the most recent procedure(except two in which residual disease was deliberately left behind). Of the 26 cases with sufficient histological description, 16 described a primary tumor that infiltrated deep to the submucosa, and 3 described lymphovascular invasion. Of the specific immunohistochemistry staining patterns studied, synaptophysin(SYN) stained all epithelioid endocrine cells(18/18). Neuron specific enolase(NSE) and SYN stained most ganglion-like cells(7/8 and 13/18 respectively), and S-100 stained all spindle-like/sustentacular cells(21/21). Our literature review of published cases of GP with lymph node metastasis underscores the excellent prognosis of GP regardless of specific treatment modality. We question the necessity of aggressive surgical intervention in select patients, and argue that local resection of the mass and metastasis may be adequate. We also emphasize the importance of pre-surgical assessment with imaging studies, as well as post-surgical follow-up surveillance for disease recurrence. | Sahara J Cathcart Aaron R Sasson Jessica A Kozel Jennifer M Oliveto Quan P Ly | 2017 | World Journal of Clinical Cases2017，5，6： | 9 |
| 2 | Mechanisms mediating the effects of alcohol and HIV anti-retroviral agents on mTORC1,mTORC2 and protein synthesis in myocytes显示文摘Alcoholism and acquired immune deficiency syndrome are associated with severe muscle wasting.This impairment in nitrogen balance arises from increased protein degradation and a decreased rate of protein synthesis.The regulation of protein synthesis is a complex process involving alterations in the phosphorylation state and protein-protein interaction of various components of the translation machinery and mammalian target of rapamycin(mTOR) complexes.This review describes mechanisms that regulate protein synthesis in cultured C2C12 myocytes following exposure to either alcohol or human immunodeficiency virus antiretroviral drugs.Particular attention is given to the upstream regulators of mTOR complexes and the downstream targets which play an important role in translation.Gaining a better understanding of these molecular mechanisms could have important implications for preventing changes in lean body mass in patients with catabolic conditions or illnesses. | Ly Q Hong-Brown Abid A Kazi Charles H Lang | 2012 | World Journal of Biological Chemistry2012，3，6： | 2 |
| 3 | Elevated levels of the angiogenic cytokines basic fibroblast growth factor and vascular endothelial growth factor in sera of cancer patients显示文摘 | Vermeuien PB Pawinski A | 1997 | British J of Cancer1997，76，2： | 1 |
| 4 | Gamma-sarcoglycan deficiency leads to muscle membrane defects and apoptosis independent of dystrophin显示文摘 | Hack A A Ly C T Jiang F | 1998 | J Cell Biol1998，142，5： | 1 |
| 5 | The mitochondrial membrane potentialin apoplosis:an update显示文摘 | Ly JD Grubb DR Lawen A | 2003 | Apoptosis2003，8，： | 1 |
| 6 | Prognostic value of human kallikrein 10 expression in epithelial ovarian carcinoma显示文摘 | Luo LY Katsaros D Scorilas A | 2001 | Clin Cancer Res2001，7，9： | 1 |
| 7 | Cancer prevention and therapy in a preclinical mouse model: impact of FHIT viruses显示文摘 | Ishii H Vecchione A Fong LY | 2004 | Curr Gcnc Thcr2004，4，1： | 1 |
| 8 | Epithelial-mesen-chymal transition as a fundamental mechanism underlyingthe cancer phenotype 显示文摘 | Cervantes-Arias A Pang LY Argyle DJ | 2012 | [ Epub ahead of print]2012，，： | 1 |
| 9 | Modulation of long- term memory for object recognition via HDAC inhibition 显示文摘 | STEFANKO D P BARRETT R M LY A R | 2009 | Proc Nail Acad Sci U S A2009，106，23： | 1 |
| 10 | Preimplantation genetic screening: does it help or hinder IVF treatment and what is the role of the embryo? 显示文摘 | Ly KD Agarwal A Nagy ZP | 2011 | J Assist Reprod Genet2011，28，9： | 1 |
| 11 | Use of HRP-2-based rapid diag- nostic test for Plasmodiumfolciparum malaria: assessing accuracy and cost effectiveness in the villages of Dielmo and Ndiop, Sene- gal显示文摘 | Ly AB Tall A Perry R | 2010 | Malar J2010，9，： | 1 |
| 12 | Comparative study of cytokine content in the plasma and wound exudate from children with severe burns显示文摘 | Mikhal' chik EV Piterskaya J A Budkevich LY eta| | 2009 | Bull Exp Biol Med2009，148，5： | 1 |
| 13 | 查看详情显示文摘 | László P Juan F G R Péter F Attila G Mihály D László A Bienvenida G Antonio M | | 0，，03： | 1 |
| 14 | Prognostic value of human kallikrein 10 expression in epithelial ovarian carcinoma显示文摘 | Luo LY Katsaros D Scorilas A | | 0，，08： | 1 |
| 15 | The serum concen- tration of human kallikrein 10 represents a novel biomark- er for ovarian cancer diagnosis and prognosis 显示文摘 | Luo LY Katsaros D Scorilas A | 2003 | Cancer Res2003，63，4： | 1 |
| 16 | Human kallikrein 10; a novel tumor marker for ovarian carcinoma? 显示文摘 | Luo LY Bunting P Scorilas A | 2001 | Clin Chim Arta2001，306，12： | 1 |
| 17 | Miniature inhalation therapy platform using surface acoustic wave microfluidic atomization显示文摘 | Qi A Friend JR Yeo LY | 2009 | Lab Chip2009，9，15： | 1 |
| 18 | The serum concentration of human kallikrein 10 represents a novel biomarker for ovarian cancer diagnosis and prognosis显示文摘 | Luo LY Katsaros D Scorilas A | | 0，，04： | 1 |
| 19 | Mechanisms of 13 - lactam antimicrobial resistance and epidemiology of major community - and healthcare - associated muhidmg - resistant bacteria 显示文摘 | Tang SS Apisarnthanarak A Hsu LY | 2014 | Adv Drug Deliv Rev2014，，78： | 1 |
| 20 | Myocardial structure and function differ in systolic and diastolic heart failure显示文摘 | VAN HEEREBEEK L BORBLY A NIESSEN H W | 2006 | Circulation2006，113，： | 1 |
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