|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Estimation and testing in generalized partial linear models-a comparative study显示文摘 | Müller M | | 0，，04： | 1 |
| 2 | Dynamic time warping 显示文摘 | Müller M | 2007 | Information Retrieval for Music and Motion2007，，： | 1 |
| 3 | Global and Local Game Tree Search显示文摘 | Müller M | 2001 | Information Sciences2001，135，34： | 1 |
| 4 | Dynamic time warping显示文摘 | Müller M | 2007 | Information Retrieval for Music and Motion2007，，1： | 1 |
| 5 | Microdialysis in clinical drug delivery studies显示文摘 | Müller M | 2000 | Adv Drug Deliv Rev2000，45，23： | 1 |
| 6 | Dynamic time warping显示文摘 | Müller M | 2007 | Information Retrieval for Music and Motion2007，，： | 1 |
| 7 | NipcoFlex和TissueFlex——适合于所有纸种脱水的靴式压榨技术显示文摘靴式压榨技术的应用范围已扩展到所有纸产品的脱水。这项有代表性的技术为日益提高的生产能力和效率提供了一种能满足任何要求的经济的解决方案 ,且该技术也应用到造纸业的压光过程中。 | ens Müller | 2004 | 中国造纸2004，23，7： | 2 |
| 8 | 应用于微型零件的热流道解决方案显示文摘微型零件的注塑成型要求采用创新的热流道解决方案,以满足注塑模具工人和模具制造商的需求。 | Volker Müller | 2008 | 现代制造2008，，40： | 2 |
| 9 | In silico analysis of regulatory networks underlines the role of miR-10b-5p and its target BDNF in huntington’s disease显示文摘Non-coding RNAs(ncRNAs)play various roles during central nervous system development.MicroRNAs(miRNAs)are a class of ncRNAs that exert their function together with argonaute proteins by post-transcriptional gene silencing of messenger RNAs(mRNAs).Several studies provide evidence for alterations in miRNA expression in patients with neurodegenerative diseases.Among these is huntington‘s disease(HD),a dominantly inherited fatal disorder characterized by deregulation of neuronal-specific mRNAs as well as miRNAs.Recently,next-generation sequencing(NGS)miRNA profiles from human HD and neurologically normal control brain tissues were reported.Five consistently upregulated miRNAs affect the expression of genes involved in neuronal differentiation,neurite outgrowth,cell death and survival.We re-analyzed the NGS data publicly available in array express and detected nineteen additional differentially expressed miRNAs.Subsequently,we connected these miRNAs to genes implicated in HD development and network analysis pointed to miRNA-mediated downregulation of twenty-two genes with roles in the pathogenesis as well as treatment of the disease.In silico prediction and reporter systems prove that levels of BDNF,a central node in the miRNA-mRNA regulatory network,can be post-transcriptionally controlled by upregulated miR-10b-5p and miR-30a-5p.Reduced BDNF expression is associated with neuronal dysfunction and death in HD.Moreover,the 3’UTR of CREB1 harbors a predicted binding site for these two miRNAs.CREB1 is similarly downregulated in HD and overexpression decreased susceptibility to 3-nitropropionic-induced toxicity in a cell model.In contradiction to these observations,it is presumed that miR-10b-5p upregulation in HD exerts a neuroprotective role in response to the mutation in the huntingtin gene.Therefore,the function of miR-10b-5p and especially its effect on BDNF expression in HD requires further academic research. | Soren Müller | 2014 | Translational Neurodegeneration2014，3，1： | 2 |
| 10 | Prodrug approaches for enhancing the bioavailability of drugs with low solubility显示文摘 | Müller CE | 2009 | Chem Biodivers2009，6，11： | 1 |
| 11 | Schwermetalle in den sedimenten des Rheins-Vernderungenseit显示文摘 | Müller G | 1979 | Umschau1979，79，24： | 1 |
| 12 | Visualization of a Covalent Intermediate between Microsomal Epoxide Hydrolase but not Cholesterol Epoxide Hydrolase and their Substrate显示文摘 | | 1997 | Eur J Biochem1997，245，： | 1 |
| 13 | Aldosterone: the minority hormone of the adrenal cortex 显示文摘 | | 1995 | Steroids1995，60，： | 1 |
| 14 | Index of geoaccumulation in sediments of the Rhine River显示文摘 | Müller G | 1969 | Geojournal1969，2，3： | 1 |
| 15 | Two kinds of stamens with different functions in the same flower 显示文摘 | Müller H | | Nature0，27，： | 1 |
| 16 | Index of geoaccumulation in sediments of the Rhine River显示文摘 | Müller G | 1969 | Geojournal1969，2，： | 1 |
| 17 | Index of geo-accumulation in sediments of the Rhine River显示文摘 | Müller G | 1969 | Geojournal1969，2，： | 1 |
| 18 | Index of geoaccumulation in sediments of the Rhine River显示文摘 | MüLLER G | 1969 | Geojournal1969，，2： | 1 |
| 19 | Gold-copper mineralization in alkaline rocks显示文摘 | | 2002 | Mineralium Deposita2002，37，： | 1 |
| 20 | An Introduction to Kernel-based Learning Algorithms显示文摘 | Müller KR | 2001 | IEEE Neural Networks2001，12，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员