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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | MeSH pesticide trace analysis using solid-phase extraction and gas chromatography with electron capture and tandem mass spectrometric detection in water samples显示文摘 | Martinez Vidal J L Pablos Espada M C Garrido Frenich A | | Jounal of Chromatography A0，，： | 2 |
| 3 | Factors regulating spatial distribution of soil water content in small semiarid catchments显示文摘 | Gomez P A Martinez M M Albaladejo J | 2000 | Journal of Hydrology2000，253，： | 1 |
| 4 | A three-dimensional finite element analysis of the combined behavior of ligaments and menisci in the healthy human knee joint 显示文摘 | Pena E Calvo B Martinez M A | 2006 | Journal of Biomechanics2006，39，9： | 1 |
| 5 | Fungicidal potential of methoxylated flavones from citrus for in vitro control of Colletotrichum loeosporioides, causal agent of anthracnose disease in tropical fruits 显示文摘 | Almada Ruiz E Martinez Tellez M A Hem ndez Alamos M M | 2003 | Pest Manag Sci2003，59，： | 1 |
| 6 | Thermal cracking of coal residues: Kinetics of asphaltene decomposition显示文摘 | MARTINEZ M T BENITO A M CALLEJAS M A | 1997 | Fuel1997，76，9： | 1 |
| 7 | Introduction of a product family penalty function using physical programming显示文摘 | Messac A Martinez M P Simpson T W | 2002 | Transactions of ASME2002，124，2： | 1 |
| 8 | PCA versus LDA显示文摘 | MARTINEZ A M KAK A C | 2001 | IEEE Transactions on Pattern Analysis and Machine Intelligence2001，23，2： | 1 |
| 9 | Decreased sperm motility in rats orally exposed to single or mixed pesticides 显示文摘 | Perobelli J E Martinez M F da Silva Franchi C A | 2010 | Journal of Toxicology and Environment Health A2010，73，1314： | 1 |
| 10 | RNA interference of HIV replication显示文摘 | Martinez M A Cohet B Este J A | 2002 | Trends Immunology2002，23，12： | 1 |
| 11 | Computational prediction of novel components of lung transcription networks 显示文摘 | Martinez M J Smith A D Li B L | 2007 | Bioinformatics2007，23，1： | 1 |
| 12 | Improved cotyledonary node method using an alternative explant derived from mature seed for efficient Agrobacterium-mediated soybean transformation 显示文摘 | Paz M M Martinez J C Kalvig A B | 2006 | Plant Cell Reports2006，25，3： | 1 |
| 13 | Diagnostics for the developing world:microfluidic paper-based analytical devices显示文摘 | Martinez A W Phillips S T Whitesides G M | 2010 | Anal Chem2010，82，1： | 1 |
| 14 | The influence of zeolite acidity for the coupled hydrogenation and ring opening of 1-methylnaphthalene on Pt/USY catalysts显示文摘 | Arribas M A Martinez A | 2002 | Applied Catalysis A : General2002，230，12： | 1 |
| 15 | Nanostructured Oxides in Chemistry显示文摘 | Fernandez G M Martinez A A Hanson J C | 2004 | Chem Rev2004，104，： | 1 |
| 16 | Physiopathology of bacterial translocation and spontaneous bacterial peritonitisin cirrhosis显示文摘 | Gonzalez Alonso R Gonzalez Garcia M Albillos Martinez A | 2007 | Gastroenterol Hepatol2007，30，2： | 1 |
| 17 | Airway inflammation and cough sensitivity in cough variant asthma 显示文摘 | De Diego A Martinez E Perpina M | 2005 | Allergy2005，60，11： | 1 |
| 18 | PCA versus LDA显示文摘 | Martinez A M Kak A C | 2001 | IEEE Transactions on Pattern Analysis and Machine Intelligence2001，23，2： | 1 |
| 19 | Ketonization of acetic acid on titania-functionalized silica monoliths 显示文摘 | Martinez R Huff M C Barteau M A | 2004 | Journal of Catalysis2004，222，2： | 1 |
| 20 | Evidence for Cu Ion Formation by Dissolution and Dealloying the Al2CuMg Intermetallic Compound in Rotating Ring--dish Collection Experiments 显示文摘 | BUCHHEIT R G MARTINEZ M A MONTES L P | 2000 | J of the Electrochemical Society2000，147，： | 1 |
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