|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 2 | Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy显示文摘 | Benson DW Perez-Atayde AR | 2002 | J Clin invest2002，109，3： | 1 |
| 3 | Regional cerebral blood flow correlated with flashback intensity in patients with posttraumatic stress disorder显示文摘 | Osuch EA Benson B Geraci M | 2001 | Biol Psychiatry2001，50，4： | 1 |
| 4 | Application of a fractional advection-dispersion equa- tion显示文摘 | BENSON D WHEATCRAFT S MEERSCHAERT M | 2000 | Water Resources Research2000，36，2： | 1 |
| 5 | Formation of trace by-products in the premixed flames of CH3Cl - C2H4 显示文摘 | Weissman M Benson S W | 1983 | J Phys Chem1983，87，2： | 1 |
| 6 | Mechanical properties of nanocrystalline materials显示文摘 | MEYERS M A MISHRA A BENSON D J | 2006 | Progress in Materials Science2006，51，： | 1 |
| 7 | The use of prostate specific antigen density to enhance the predictive value of intermediate levels of serum prostate specific antigen显示文摘 | BENSON M C WHANG I S OLSSON C A | 1992 | J Urol1992，147，： | 1 |
| 8 | Analytical formulation for the shielding effectiveness of enclosures with apertures显示文摘 | Robinson M P Benson T M Christopoulos C | 1998 | IEEE Trans on Electromagn Compat1998，40，3： | 1 |
| 9 | Phototransduc- tion by retinal ganglion cells that set the circadian clock显示文摘 | Benson DM Dunn FA Takao M | 2002 | Science2002，295，5557： | 1 |
| 10 | Identity consequences of attachment to mothers and fathers among late adolescents显示文摘 | Benson M J Harris P B Rogers C S | | 0，，02： | 1 |
| 11 | Insertion ele- ment analysis and mapping of the Pseudomonas plasmid alk regulon 显示文摘 | Fennewald M Benson S Oppici M Shapiro J | 1979 | J Bacteriol1979，139，3： | 1 |
| 12 | Effects of sensor spatial resolution on landscape structure parameters显示文摘 | Benson B J MacKenzie M D | 1995 | Land- scape Ecology1995，10，2： | 1 |
| 13 | Effects of sensor spatial resolution on landscape structure parameters显示文摘 | BENSON B J MACKENZIE M D | 1995 | Landscape Ecology1995，10，2： | 1 |
| 14 | Isogeometric shellanalysis:the Reissner-Mindlin shell显示文摘 | Benson D J Bazilevs Y Hsu M C | 2010 | Computer Methodsin Applied Mechanics and Engineering2010，199，27： | 1 |
| 15 | Three-to six-year follow-up of stand-alone BAK cages implanted by a single surgeon 显示文摘 | Button G Gupta M Barrett C Cammack P Benson D | 2005 | Sline J2005，5，： | 1 |
| 16 | Analytical formulation for the shielding effectiveness of enclosures with apertures显示文摘 | Robinson M P Benson T M Christopoulos C | 1998 | IEEE Transactions on Electromagnetic Compatibility1998，40，3： | 1 |
| 17 | Inverse relation between nasal fluid Clara Cell Protein 16 levels and symptoms and signs of rhinitis in allergen-challenged patients with intermittent allergic rhinitis显示文摘 | Benson M Fransson M Martinsson T | 2007 | Allergy2007，62，2： | 1 |
| 18 | Correlating index properties and hydraulic conductivity of geosynthetic clay liners显示文摘 | LEE J M SHACKELFORD C' D BENSON C H | 2005 | Journal of Geotechnical and Geoenvironmental Engineering2005，131，11： | 1 |
| 19 | The unique enve lope gene of the subgroup J avian leukosis virus de rives from ev/J provirus, a novel family of avian en dogenous viruses显示文摘 | Benson S J Ruis B Fadly A M | 1998 | J Virol1998，72，10： | 1 |
| 20 | Subordinated advection-dispersion equation for contaminant transport显示文摘 | BAEUMER B MEERSCHAERT M M BENSON D A | 2001 | Water Resources Research2001，37，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员