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| 1 | Effects of probiotic bacteria on gastrointestinal motility in guinea-pig isolated tissue显示文摘AIM: To evaluate the intestinal motility changes evoked by 8 bacterial strains belonging to Bifidobacterium , Lactobacillus and Streptococcus genera within the probiotic preparation VSL#3. METHODS: Ileum and proximal colon segments isolated from guinea-pigs were used as a study model. Entire cells and cell fractions (cell debris, cell wall fraction, cytoplasmatic fraction, proteinaceous and non- proteinaceous cytoplasmatic components) of VSL#3 strains and, as controls, Escherichia coli, Salmonella aboni and Bacillus licheniformis were tested in this in vitro model. RESULTS: Among the bacterial cell fractions tested, only the cytoplasmatic fraction modified intestinal motility. Lactobacillus strains stimulated the contraction of ileum segment, whereas all probiotic strains tested induced proximal colon relaxation response. The non-proteinaceous cytoplasmatic components were responsible for the colon relaxation. CONCLUSION: The results obtained in this study suggest that the proximal colon relaxation activity showed by the probiotic bacteria could be one of the possible mechanisms of action by which probiotics exert their positive effects in regulating intestinal motility. | Matteo Massi Pierfranco Ioan Roberta Budriesi Alberto Chiarini Beatrice Vitali Karen M Lammers Paolo Gionchetti Massimo Campieri Anthony Lembo Patrizia Brigidi | 2006 | World Journal of Gastroenterology2006，12，37： | 3 |
| 2 | The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug- resistant human T-acute leukemia ceils by a JNK-dependent mechanism 显示文摘 | Chiarini F Del Sole M Mongiorgi S | 2008 | Leukemia2008，22，6： | 1 |
| 3 | The novel Akt inhibitor, perifosine, induces caspase-dependent ap- optosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism 显示文摘 | Chiarini F Del Sole M Mongiorgi S | 2008 | Leukemia2008，22，6： | 1 |
| 4 | Myelolipomatosis : a report of a case located in the mandible 显示文摘 | Chiarini L Bertoldi C Criscuolo M | 1992 | Minerva Stomatol1992，41，4： | 1 |
| 5 | The novel Akt inhibitor,perifosine,induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in mul- tidrug-resistant human T-acute leukemia cells by a JNK- dependent mechanism 显示文摘 | Chiarini F Del Sole M Mongiorgi S | 2008 | Leukemia2008，22，6： | 1 |
| 6 | Calcium- sensing receptor ( CaSR ) in human brain' s pathophysiology: roles in late-onset Alzheimer' s disease (LOAD) 显示文摘 | Chiarini A Dal Pra I Marconi M | 2009 | Curr Pharm Biotecbnol2009，10，3： | 1 |
| 7 | Cellular prion protein transduces neuroprotective signals显示文摘 | Chiarini L B Freitas A R Zanata S M | 2002 | EMBO J2002，21，13： | 1 |
| 8 | Cellular prion protein transduces neuroprotective signals显示文摘 | CHIARINI L B FREITAS A R ZANATA S M | 2002 | EMBOJ2002，21，： | 1 |
| 9 | T-cell receptor and K-deleting recombination excision circles in newborn screening of T- and B-cell defects: review of the literature and future challenges显示文摘 | Chiarini M Zanotti C Serana F | 2013 | J Public Health Res2013，2，1： | 1 |
| 10 | Use of V (D) J recombination excision circles to identify T- and B-cell defects and to monitor the treatment in primary and acquired immunodefieiencies显示文摘 | Serana F Chiarini M Zanotti C | 2013 | J Transl Med2013，11，10： | 1 |
| 11 | Cellular prion protein transduees neuroprotective signals显示文摘 | Chiarini L B Freitas A R Zanata S M | 2002 | EMBO J2002，21，13： | 1 |
| 12 | Reduction of peripheral blood T cells producing IFN-γ and IL-17 after therapy with abataeept for rheumatoid arthritis 显示文摘 | Scarsi M Zanotti C Chiarini M | 2014 | Clin Exp Rheumatol2014，32，2： | 1 |
| 13 | Cellular prion protein transduces neuroprotective signals显示文摘 | Chiarini L B Freitas A R Zanata S M | 2002 | EMBO J2002，21，： | 1 |
| 14 | Opposite effects of interferon-beta on new B and T cell release from production sites in multiple sclerosis patients 显示文摘 | Zanotti C Chiarini M Serana F | 2011 | J Neuroimmunol2011，15，24： | 1 |
| 15 | Biological treatment of alkaline industrial waste waters显示文摘 | BACCELLAA S CERICHELLIB G CHIARINI M | 2000 | Process Biochemistry2000，35，6： | 1 |
| 16 | Cellular prian pro- tein transduces neumprotective signals显示文摘 | Chiarini L B Freitas A R Zanata S M | 2002 | EMBO J2002，，21： | 1 |
| 17 | Cellular prion protein transduces neuroprotective signals 显示文摘 | CHIARINI L B FREITAS A R ZANATA S M el al | 2002 | MBO J2002，21，： | 1 |
| 18 | Noninvasive ventilation in children with spinal muscular atrophy types 1 and 2 显示文摘 | Petrone A Pavone M Chiarini Testa MB | 2007 | Am J Phy Med Rehabil2007，86，3： | 1 |
| 19 | The emer-ging role of the phosphatidylinositol 3-Kinase/Akt/mam-malian target of rapamycin signaling network in cancerstem cell biology显示文摘 | Martelli A M Evangeiisti C Chiarini F | 2010 | Cancers2010，2，3： | 1 |
| 20 | A new green approach tothe Friedlander synthesis of quinolines 显示文摘 | Arcadi A Chiarini M Giuseppe SD ei al | 2003 | Synlett2003，1，2： | 1 |
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