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| 1 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 2 | 油炸食品与心血管病风险和全因死亡率的关系:观察性研究的荟萃分析显示文摘研究者进行了一项荟萃分析,包括剂量反应分析,以定量确定油炸食品摄入与普通成年人群心血管病风险和全因死亡率之间的关系。方法:研究者在PubMed、EMBASE和Web of Science上检索2020年4月11日之前的所有文章。应用随机效应模型估计总的相对危险度(relative risks,RR)和95%CI。结果:与最低油炸食品摄入量相比,最高摄入量者主要心血管事件的总RR(95%CI)=1.28(1.15~1.43),n=17,I^(2)=82.0%,其中前瞻性研究:1.24(1.12~1.38),n=13,I^(2)=75.7%. | 刘青(译) 练桂丽(审校) Qin P Zhang M Han M Liu D Luo X Xu L Zeng Y Chen Q Wang T Chen X Zhou Q Li Q Qie R Wu X Li Y Zhang Y Wu Y Hu D Hu F | 2021 | 中华高血压杂志2021，29，2： | 3 |
| 3 | Origin and technic significance of a Mesozoic multi-layer over-thrust system within the Yangtze Block (South china)显示文摘 | Yan D P Zhou M F Song H L | 2003 | Tectonophysics2003，361，： | 1 |
| 4 | Load Factor Calibration for the Proposed 2005 Edition of the National Building Code for Canada: Companion-action Load Combinations 显示文摘 | Bartlett F M Hong H P Zhou W | 2003 | Canadian Journal of Civil Engineering2003，，30： | 1 |
| 5 | Antioxidant and free radical- scavenging activities of wheat germ protein bydrolysates ( WGPH ) prepared with alcalase 显示文摘 | ZHU K X ZHOU H M QIAN H F | 2006 | Process Biochemistry2006，41，： | 1 |
| 6 | Mechanisms for oil depletion and enrichment on the Shijiutuo uplift, Bohai Bay Basin, China 显示文摘 | HAO F ZHOU X H ZHU Y M | 2009 | AAPG Bulletin2009，93，8： | 1 |
| 7 | Trace Elemental and PGE Geochemical Constraints of Mesozoic and Cenozoic Peridotitic Xenoliths on Lithospheric Evolution of the North China Craton显示文摘 | Zheng J P Sun M Zhou M F | 2005 | Geochimica et Cosmoehimica Acta2005，69，13： | 1 |
| 8 | Correlation betw een myopia and major biometric parameters of the eye:a retrospective clinical study显示文摘 | Xie R Zhou XT Lu F Chen M Xue A Chen S | 2009 | Optom Vis Sci2009，86，5： | 1 |
| 9 | Carbon dioxide and nitrous oxide fluxes in corn grown under two tillage systems in Southwestern Quebec显示文摘 | Almaraz J J Mabood F Zhou X M | 2009 | Soil Science Society of America Journal2009，73，1： | 1 |
| 10 | High-chromium and high-alu minum podiform chromitites,western china:relationship to partial melting and melt/rock interaction in the upper mantle 显示文摘 | Zhou M F Robinson P T | 1994 | Intel Geol Rev1994，36，： | 1 |
| 11 | Electrokinetic remediation of a Cu contaminated red soil by conditioning catholyte pH with different enhancing chemical reagents显示文摘 | Zhou D M Deng C F Cang L | 2005 | Chemosphere2005，56，33： | 1 |
| 12 | Electrokinetic remediation of a Cu contaminated red soil by conditioning catholyte pH with different enhancing chemical reagents显示文摘 | Zhou D M Deng C F Cang L | 2004 | Chemosphere2004，56，： | 1 |
| 13 | Evaluation of C-14 ages of organic fractions of paleosols from loess-paleosol sequences near Xian, China 显示文摘 | Head M J Zhou W J Zhou M F | 1989 | Radiocarbon1989，31，： | 1 |
| 14 | Narrow-band interfe-rence suppression for SAR based on complex empirical mode decomposition显示文摘 | ZHOU F XING M BAI X | 2009 | IEEE Geoscience and Remote Sensing Letters2009，6，3： | 1 |
| 15 | A temporal link between the Emeishan large igneous province (SW China) and the end-Guagalupian mass extinction 显示文摘 | Zhou M F Malpas J Song X Y Robinson P T Sun M Kennedy A K Lesher C M Keays R R | 2002 | Earth arut Planetary Science Letters2002，196，： | 1 |
| 16 | 2013, Antigenic and genetic characterization of a European avian-like H1N1 swine influenza virus from a boy in China in 2011显示文摘 | Qi x Cui L Jiao Y Pan Y Li X Zu R Huo X Wu B Tang F Song Y Zhou M Wang H Cardona C J Xing Z | 2013 | Archives of Virology2013，158，1： | 1 |
| 17 | SHRIMP U - Pb zircon geochronological and geochemical evidence for Neoproterozoic arc-magmatism along the western margin of the Yangtze Block, South China 显示文摘 | Zhou M F Yan D P Kennedy A K | 2002 | Earth and Planetary Science Letters2002，196，1： | 1 |
| 18 | Graphene-wrapped Fe3 04 anode materials with improved reversiblecapacity and cyclic stability for lithium ion batteries 显示文摘 | ZHOU G M WANG D W LI F | 2010 | Chemistry materials2010，，22： | 1 |
| 19 | Oxidation behavior and breakdown of an aluminide coating on DZ40M alloy at high temperatures显示文摘 | Liu P S Liang K M Zhou H Y Guan H R Sun X F Jin T Yang K N | 2001 | Oxidation of Metals2001，55，56： | 1 |
| 20 | Hepatic angiomyolipoma: vari- ous appearance on two-phase contrast scanning of spiral CT 显示文摘 | Yah F Zeng M Zhou K | 2002 | Eur Radiol2002，41，1： | 1 |
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