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| 1 | 宫颈癌组织中FHIT基因5'端CpG岛甲基化及其与基因失活的关系显示文摘背景与目的:脆性组氨酸三联基因(fragile histidine triad gene,FHIT)作为抑癌基因与多种实体瘤的发生有关,并在多种肿瘤中因甲基化而失活。本研究拟探讨宫颈癌组织中FHIT基因5'端CpG岛甲基化状况及其与基因失活的关系。方法:采用甲基化特异性聚合酶链反应(methylation鄄specificPCR,MSP)和免疫组织化学法分别检测10例正常宫颈鳞状上皮、40例宫颈癌组织中FHIT基因5'端CpG岛的甲基化发生状况和FHIT蛋白表达情况。结果:(1)正常宫颈鳞状上皮组织中未发现存在FHIT基因甲基化状态,而宫颈癌组织中FHIT基因5'端CpG岛的甲基化率为40.0%(16/40);(2)临床Ⅱ期宫颈癌病例中FHIT基因甲基化的发生率为56.5%(13/23),明显高于Ⅰ期的14.3%(2/14)(P<0.05);(3)宫颈癌组织中存在FHIT蛋白表达降低或缺失,阳性率仅为30.0%(12/40),显著低于正常宫颈组织的100.0%(10/10)(P<0.05)。结论:FHIT基因5'端CpG岛甲基化是宫颈癌中该基因失活的机制之一,可能与宫颈癌的发生发展有关。 | 史惠蓉 吴庆华 索振河 Jahn M Nesland | 2005 | 癌症2005，24，1： | 20 |
| 2 | 乳腺癌组织中TP和TS及DPD mRNA表达与预后的关系显示文摘目的 探讨乳腺癌组织中胸苷酸化酶 (TP)、胸苷酸合成酶 (TS)和二氢嘧啶脱氢酶(DPD)mRNA表达水平及其与预后的关系。方法 采用real time定量PCR技术检测经过微选的 9例正常乳腺组织和 86例乳腺癌组织TP、TS和DPD的mRNA表达水平。结果 肿瘤组织中TP、TS和DPDmRNA表达水平中位数分别为 16 .5 4 ,0 .38和 2 .74 ,正常乳腺组织分别为 11.75 ,0 .2 5和 8.33,差异均无显著性 (P >0 .0 5 )。除年龄与DPD表达呈负相关外 ,TP、TS和DPDmRNA表达与肿瘤体积、淋巴结转移、组织学分级、临床分期均无相关性。TP、DPD高表达组和低表达组之间 ,无瘤生存期和总生存期差异均无显著性。TS高表达组和低表达组无瘤生存期差异无显著性 (P =0 .0 6 9) ;平均总生存期分别为 5 9.0 0和 70 .30个月 ,差异有显著性 (P =0 .0 4 96 )。结论 仅检测TSmRNA对判断乳腺癌预后有参考价值 ,同时检测TP、TS和DPD具有更好的预测价值。 | 李惠翔 Suo ZH 张云汉 Bjrn Risberg Mats G Karlsson Jahn M Nesland | 2004 | 中华肿瘤杂志2004，26，11： | 9 |
| 3 | Expression of seprase in effusions from patients with epithelial ovarian carcinoma显示文摘背景 Seprase 由降级在恶意的房间侵略和转移起一个重要作用细胞外的矩阵。Hcwever,它的临床的意义仍然保持大部分未知。学习是与上皮的卵巢的癌和它的临床的 values.Methods Immunohistochemistry 从病人在流出计算 seprase 的表达式的水流的目的被用来在一系列 74 恶意的腹( n=64 )检验 seprase 蛋白质的表示并且肋膜( n=10 )从挪威的病人与的流出上皮卵巢的癌。另外, 34 流出用西方的弄污被评估。九反应流出,与良性的损害从病人获得了,担任了一个控制组。统计分析被 74 个恶意的流出标本的 Chi 平方测试和 Kaplan-Meier method.Results 执行,(77.02%) 57 为 seprase 是积极的,当(22.22%) 仅仅 2 断然控制组被染色时(P=0.001 ) 。在恶意的流出, 17 (22.97%) , 22 (29.73%) , 22 (29.73%) ,(17.57%) 13 分别地有否定、弱、中等、强壮的 seprase 蛋白质表示。seprase 蛋白质的表示在癌房间的细胞质是占优势的。增加的 seprase 蛋白质否定地与病人(P=0.03 ) 的全面幸存率被联系。然而,在蛋白质之间没有重要关联表示和 FIGO 舞台,年龄,组织学,和组织学的等级。由西方的弄污, 34 流出中的 27 个显示出当仅仅 34 中的 1 个有 170-KD 时,二聚的形式和 97-KD monomeric seprase 形成的两 170-kD 的存在二聚的形式,它与 immunohistochemistry ( P=0.05 )的结果一致 .Conclusions Seprase 可以涉及卵巢的癌症的发展,并且是为疾病的一个潜在的预兆的标记。 | ZHANG Meng-zhen QIAO Yu-huan Jahn M Nesland SUO Zhen-he | 2007 | Chinese Medical Journal2007，，8： | 8 |
| 4 | On-target temporal characterization of optical pulses at relativistic intensity显示文摘High-field experiments are very sensitive to the exact value of the peak intensity of an optical pulse due to the nonlinearity of the underlying processes.Therefore,precise knowledge of the pulse intensity,which is mainly limited by the accuracy of the temporal characterization,is a key prerequisite for the correct interpretation of experimental data.While the detection of energy and spatial profile is well established,the unambiguous temporal characterization of intense optical pulses,another important parameter required for intensity evaluation,remains a challenge,especially at relativistic intensities and a few-cycle pulse duration.Here,we report on the progress in the temporal characterization of intense laser pulses and present the relativistic surface second harmonic generation dispersion scan(RSSHG-D-scan)—a new approach allowing direct on-target temporal characterization of high-energy,few-cycle optical pulses at relativistic intensity. | Vyacheslav E.Leshchenko Alexander Kessel Olga Jahn Mathias Kruger Andreas Münzer Sergei ATrushin Laszlo Veisz Zsuzsanna Major Stefan Karsch | 2019 | Light(Science & Applications)2019，8，1： | 2 |
| 5 | Two-and three-dimensional ray tracing applied to the land mobile satellite(LMS) progagtion channel显示文摘 | Dottling M Jahn A Didascalou D | 2001 | Antennas and Propagation Magazine2001，43，6： | 1 |
| 6 | Geochemistry and isotope data on an ultrahigh-pressure jadeite quartzite from Shuanghe,Dabie Mountains,Eastern China显示文摘 | Liou J G Zhang R Y Jahn B M | 1997 | Lithos1997，41，： | 1 |
| 7 | Two contrasting Paleozoic magmatic belts in northern Inner Mongolia,China: petrogenesis and tectonic implications 显示文摘 | CHEN Bin Jahn B M Wilde S | 2000 | Tectonophysics2000，328，： | 1 |
| 8 | Use of support vector machines for dis- ease risk prediction in genome - wide association studies : Concerns and opportunities显示文摘 | Mittag F Saad M Jahn A | 2012 | Human Mutation2012，33，12： | 1 |
| 9 | A new gene, Nytor, for hypersensitivity to Potato virus Y from Solarium tuberosum maps to chromosome IV显示文摘 | Celebi-Toprak F Slack S A Jahn M M | 2002 | Theoretical and Applied Genetics2002，104，： | 1 |
| 10 | Two contrasting Paleozoic magmatic belts in northern Inner Mongolia,China:Petrogenesis and tectonic implications显示文摘 | Chen Bin Jahn B M Wilde S | | 0，，： | 1 |
| 11 | Defensin alpha 6 (DEFA 6)overexpression threshold of over 60 fold can distinguish between adenoma and fully blown colon carcinoma in individual patients显示文摘 | RADEVA M Y JAHNS E WILHELM A | 2010 | BMC Cancer2010，2710，： | 1 |
| 12 | Continental growth in the Phanerozoic:Evidence from Central Asia显示文摘 | Jahn B M Griffin W L Windley B F | 2000 | Tectonophysics2000，328，： | 1 |
| 13 | Highly fractionated I-type granites in NE China(I):Gechronology and petrogenesis显示文摘 | Wu F Y Jahn B M Wilde S A | 2003 | Lithos2003，66，3： | 1 |
| 14 | Plume-lithosphere interaction in generation of the Emeishan flood basalts at the Permian-Triassic boundary显示文摘 | Chung S L Jahn B M | 1995 | Geology1995，23，： | 1 |
| 15 | Optimizing the Selection of Partners in Production Networks显示文摘 | FISCHER M JAHN H TEICH T | 2004 | Robotics and Computer-Integrated Manufacturing2004，20，3： | 1 |
| 16 | Mesozoic felsic arc magmatism and continental olivine tholeiites in Zhejiang Province and their relationship with the tectonic activity in southeastern China显示文摘 | Lapierre H Jahn B M Charvet J | 1997 | Tectonophysics1997，274，4： | 1 |
| 17 | Thioglycoligases:mutant glycosidases for thioglycoside synthesis显示文摘 | Jahn M Marles J Warren R | 2003 | Angew Chem Int Ed2003，42，： | 1 |
| 18 | Geochemical characterization of the Luochuan loess-paleosol sequence, China, and paleoclimatic implications显示文摘 | GALLET S JAHN B M TORII M | 1996 | Chemical Geology1996，133，： | 1 |
| 19 | Phase current reconstruction for AC motor drives using a DC link single current sensor and measurement voltage vectors显示文摘 | KIM H JAHNS T M | 2006 | IEEE Transactions onPower Electronics2006，121，5： | 1 |
| 20 | Evolution of the Solonker suture zone:Constraints from zircon U-Pb ages,Hf isotopic ratios and whole-rock Nd-Sr isotope compositions of subduction and collision-related magmas and forearc sediments显示文摘 | Chen B Jahn B M Tian W | | 0，，3： | 1 |
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