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| 1 | Esophageal tuberculosis presenting with hematemesis显示文摘Esophageal tuberculosis is rare, constituting about 0.3% of gastrointestinal tuberculosis. It presents commonly with dysphagia, cough, chest pain in addition to fever and weight loss. Complications may include hemorrhage from the lesion, development of arterioesophageal fistula, esophagocutaneous fistula or tracheoesophageal fistula. There are very few reports of esophageal tuberculosis presenting with hematemesis due to ulceration. We report a patient with hematemesis that was due to the erosion of tuberculous subcarinal lymph nodes into the esophagus. A 15-year-old boy presented with hemetemesis as his only complaint. Esophagogastroduodenoscopy(EGD) revealed an eccentric ulcerative lesion involving 50% of circumference of the esophagus. Biopsy showed caseating epitheloid granulomas with lymphocytic infiltrates suggestive of tuberculosis. Computerised tomography of the thorax revealed thickening of the mid-esophagus with enlarged mediastinal lymph nodes in the subcarinal region compressing the esophagus along with moderate right sided pleural effusion. Patient was treated with anti-tuberculosis therapy(Rifampicin, Isoniazid, Pyrazinamide, Ethambutol) for 6 mo. Repeat EGD showed scarring and mucosal tags with complete resolution of the esophageal ulcer. | Samit S Jain Piyush O Somani Rajeshkumar C Mahey Dharmesh K Shah Qais Q Contractor Pravin M Rathi | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，11： | 6 |
| 2 | Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus显示文摘AIM To investigate the role of glucagon-like peptide-1(GLP-1)/glucagon receptors coagonist on renal dysfunction associated with diabetes and obesity. METHODS Chronic high-fat diet fed C57 BL/6 J mice, streptozotocintreated high-fat diet fed C57 BL/6 J mice and diabeticC57 BLKS/J db/db mice were used as models of diabetes-induced renal dysfunction. The streptozotocintreated high-fat diet fed mice and db/db mice were treated with the GLP-1 and glucagon receptors coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) for twelve weeks, while in chronic high-fat diet fed mice, coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) treatment was continued for forty weeks. Kidney function, histology, fibrosis, inflammation, and plasma biochemistry were assessed at the end of the treatment. RESULTS Coagonist treatment decreased body weight, plasma lipids, insulin resistance, creatinine, blood urea nitrogen, urinary albumin excretion rate and renal lipids. In kidney, expression of lipogenic genes(SREBP-1 C, FAS, and SCD-1) was decreased, and expression of genes involved in β-oxidation(CPT-1 and PPAR-α) was increased due to coagonist treatment. In plasma, coagonist treatment increased adiponectin and FGF21 and decreased IL-6 and TNF-?. Coagonist treatment reduced expression of inflammatory(TNF-α, MCP-1, and MMP-9) and pro-fibrotic(TGF-β, COL1 A1, and α-SMA) genes and also improved histological derangement in renal tissue.CONCLUSION Coagonist of GLP-1 and glucagon receptors alleviated diabetes and obesity-induced renal dysfunction by reducing glucose intolerance, obesity, and hyperlipidemia. | Vishal J Patel Amit A Joharapurkar Samadhan G Kshirsagar Brijesh K Sutariya Maulik S Patel Hiren M Patel Dheerendra K Pandey Rajesh H Bahekar Mukul R Jain | 2018 | World Journal of Diabetes2018，9，6： | 5 |
| 3 | Primary hepatic amyloidosis:A case report and review ofliterature显示文摘We describe a case of 42-year-old female presenting with abdominal pain associated with loss of weight and fever for 8 mo. On evaluation she had gross hepatomegaly with raised alkaline phosphatase and raised GGT levels with normal transaminases and bilirubin. On imaging she had diffuse enlargement of liver with heterogeneous contrast uptake in liver. Her viral marker and autoimmune markers were negative. Liver biopsy depicted massive deposition of amyloid in peri-sinusoidal spaces which revealed apple green birefringence on polarizing microscopy after Congo red staining. Cardiac and renal evaluation was unremarkable. Abdominal fat pad and rectum biopsy was negative for amyloid deposit. There was no evidence of primary amyloidosis as bone marrow examination was normal. Serum and urine immunofixation electrophoresis were normal. Immunoperoxidase staining for serum amyloid associated protein for secondary amyloidosis was negative from liver biopsy. We present this rare case of primary hepatic amyloidosis and review the literature regarding varied presentations of hepatic involvement in amyloidosis. | Nikhil Sonthalia Samit Jain Sunil Pawar Vinay Zanwar Ravindra Surude Praveen M Rathi | 2016 | World Journal of Hepatology2016，8，6： | 3 |
| 4 | A new technique for the analysis of self-excited induction generator显示文摘 | SINGH S P JAIN M P | 1995 | Electric Machine and Power Systems1995，23，： | 2 |
| 5 | Role of interstitial cells of Cajal in motility disorders of the bowel显示文摘 | Jain D Moussa K Tandon M | 2003 | Am J Gastroenterol2003，98，3： | 2 |
| 6 | Data clustering:a review显示文摘 | JAIN A K MURTY M N FLYNN P J | 1999 | AGM Computing Surveys1999，31，3： | 2 |
| 7 | Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infaretion显示文摘 | Jain M DerSimonian H Brenner DA | 2001 | Circulation2001，103，： | 1 |
| 8 | On pre-straining and the evolution of material anisotropy in sheet metals显示文摘 | WU P D MACEWEN S R LLOYD D J JAIN M TUGCU P NEALE K W | 2005 | Int J Plasticity2005，21，： | 1 |
| 9 | Time and pH Dependent Colon Specific, Pulsatile Delivery of Theophylline for Nocturnal Asthma显示文摘 | Mastiholimath V S Dandagi P M Samata Jain S Gadad A P Kulkarni A R | 2007 | International Journal of Pharmaceutics2007，328，： | 1 |
| 10 | N-policy for a machine repair system with spares and reneging显示文摘 | JAIN M Rakhee MAHESHWARI S | 2004 | Applied Mathematical Modeling2004，28，： | 1 |
| 11 | an XPS study of the effect of ZDDP on the AW/EP characteristics of molybdenum based additives 显示文摘 | Unnikrishnan R Jain M C Additive-additive interaction: Harinarayan A K | 2002 | Wear2002，252，3： | 1 |
| 12 | STAT3 and MAPK signaling maintain overexpression of heat shock proteins 90alpha and beta in multiple myeloma ceils, which critically contribute to tumorcell survival 显示文摘 | Chatterjee M Jain S Sttihmer T | 2007 | Blood2007，109，2： | 1 |
| 13 | Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction显示文摘 | Jain M Dersimonian H Brenner DA | 2001 | Circulation2001，103，： | 1 |
| 14 | Why the bass model fits without decision variables显示文摘 | Bass F M Kvishnan T V Jain D C | 1994 | Marketing Science1994，13，3： | 1 |
| 15 | Cell therapy anenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction显示文摘 | Jain M DerSimonian H Brenner DA | 2001 | Circulation2001，103，14： | 1 |
| 16 | Modeling of material removal and surface roughness in abrasive flow machining process显示文摘 | Jain R K Jain V K Dixit P M | 1999 | International Journal of Machine Tools & Manufacture1999，39，19： | 1 |
| 17 | Cell therapy attenuates deleterious ventricular remodeling and improve cardiac performance after myocardial infarction显示文摘 | JAIN M DERASIMONIAN H DANIEL A | 2001 | Circulation2001，103，： | 1 |
| 18 | Constrictive pericarditis显示文摘 | Mehta A Mehta M Jain AC | 1999 | Clin Cardiol1999，22，5： | 1 |
| 19 | Removal of congo red dye from water using carbon slurry waste显示文摘 | Bhatnagar A Jain A K Mukul M K | 2005 | Environmental Chemistry Letters2005，2，： | 1 |
| 20 | Methane and nitrous oxide emissions from an irrigated rice of North India显示文摘 | Ghosh Sabyasachi Majumdar Deepanjan Jain M C | 2003 | Chemosphere2003，51，： | 1 |
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