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| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | Adaptive immunity in the liver显示文摘 | Zongwen Shuai Miranda WY Leung Xiaosong He Weici Zhang Guoxiang Yang Patrick SC Leung M Eric Gershwin | 2016 | Cellular & Molecular Immunology2016，13，3： | 3 |
| 3 | Streptococcus agalactiae:Identification methods,antimicrobial susceptibility, and resistance genes in pregnant women显示文摘BACKGROUND Group B Streptococcus(GBS)is a normal component of the gastrointestinal and genital microbiota in humans and can lead to important infections in newborns.AIM To compare GBS isolation and identification methods as well as to assess the antibiotic susceptibility and to identify resistance genes in GBS strains from pregnant women attended in healthcare services from the city of Vitória da Conquista,in Bahia State,Brazil.METHODS From January 2017 to February 2018,vaginorectal swabs were obtained from 186 participants and the samples were seeded onto chromogenic agar for GBS before and after inoculation in selective broth.Confirmatory identification using 3 CAMP and latex tests was performed in samples with GBS-suggestive colonies.Then,disk diffusion antibiograms were performed in GBS-positive samples,and the detection of the resistance genes ermB,ermTR,mefA,and linB in the clindamycin and/or erythromycin-resistant samples was carried out.RESULTS Thirty-two samples(17.2%)were GBS-positive.The culture in chromogenic agar after sample incubation in selective broth was the most sensitive method(96.9%)for GBS detection.All isolates were susceptible to penicillin,ampicillin,cefotaxime,and vancomycin.Clindamycin resistance was observed in 6 samples(18.8%),while 8 samples(25%)were erythromycin-resistant.All erythromycin and/or clindamycin-resistant GBS strains had negative D-tests.Two strains(25%)presented an M phenotype and 6 isolates(75%)presented a cMLSB phenotype.The ermB gene was identified in 4 samples(44.4%),the mefA gene was also found in 4 samples(44.4%),the ermTR gene was identified in 1 isolate(11.1%),and the linB gene was not found in any isolate.CONCLUSION This study evidenced that the screening for SGB can be performed by means of various methods,including chromogenic media,and that the chemoprophylaxis for pregnant women who cannot use penicillin must be susceptibility-guided. | Fabrícia Almeida Fernandes Santana Tais Viana Ledo de Oliveira Marcelo Barreto de Souza Filho Lucas Santana Coelho da Silva Breno Bittencourt de Brito Fabrício Freire de Melo Cláudio Lima Souza Lucas Miranda Marques Márcio Vasconcelos Oliveira | 2020 | World Journal of Clinical Cases2020，8，18： | 2 |
| 4 | Structure properties of hydroxyapatite obtained by mechanosynthesis 显示文摘 | Silva C C Pinheiro A G Miranda M A R | 2003 | Solid State Sciences2003，5，： | 1 |
| 5 | Considerations on reproducibility of potential and corrosion rate measurements in reinforced concrete显示文摘 | GonzalezJ A Miranda J M Feliu S | 2004 | Corros Sci2004，46，： | 1 |
| 6 | Corrosion behaviour of new stainless steels reinforcing bars embedded in concrete 显示文摘 | Garcia-Alonso M C Escudero M L Miranda J M | 2007 | Cement and Concrete Research2007，37，10： | 1 |
| 7 | PP2A regulatory subunit PP2A-B'counteracts S6K phosphorylation显示文摘 | Hahn K Miranda M Francis VA | 2010 | Cell Metabol2010，11，5： | 1 |
| 8 | Nodulating ability of Rhizobium tropici is conditioned by a plasmid encoded citrate synthase显示文摘 | PARDO M A LAGUNEZ J MIRANDA J | 1994 | Mol Microbiol1994，11，： | 1 |
| 9 | Singular and non-singular approaches for predicting fatigue crack growth be- havior显示文摘 | Castro J T P Meggiolaro M A Miranda A C O | 2005 | International Journal of Fatigue2005，27，： | 1 |
| 10 | Curing temperature effect on mechanical strength of smokeless fuel briquettes pre- pared with molasses 显示文摘 | Blesa M J Miranda J L Izquierdo M T | 2003 | Fuel2003，82，8： | 1 |
| 11 | Noninvasive measur- ements of regional cerebral per'fusion in preterm and term neonates by magnetic resonance arterial spin labeling显示文摘 | Miranda M J Olofsson K Sidaros K | 2006 | Pedialr Res2006，60，3： | 1 |
| 12 | Vasopressin and the regulation of aquaporin-2 显示文摘 | Wilson J L Miranda C A Knepper M A | 2013 | Clin Exp Nephrol2013，17，： | 1 |
| 13 | Modeling the current distribution during transcranial direct current stimulation 显示文摘 | Miranda PC Lomarev M Hallett M | 2006 | Clin Neurophysiol2006，117，7： | 1 |
| 14 | 显示文摘 | Feliu S Gonzalez J A Miranda J M | 2005 | Corrosion Science2005，47，： | 1 |
| 15 | Forme fruste of neuroleptic ma- lignant syndrome associated with the use of sertraline 显示文摘 | Miranda M Soto F Fischman P | 2011 | Parkin- sonism Relat Disord2011，17，3： | 1 |
| 16 | Personality and Team Performance : A Meta - Analysis 显示文摘 | Miranda A G Peeters Harrie F J M Vantuijl Christel G Rutte Isabelle M M J Reymen | 2006 | European Journal of Personality2006，，20： | 1 |
| 17 | Selective suppres- sion of late laryngeal adductor responses by N-methyl-D- aspartate receptor blockade in the cat显示文摘 | Ambalavanar R Purcell L Miranda M | 2002 | J Neurophysiol2002，87，3： | 1 |
| 18 | Curing temperature effect on smokeless fuel briquettes prepared with molasses and H3 PO4 显示文摘 | Blesa M J Miranda J L Moliner R | 2003 | Fuel2003，82，13： | 1 |
| 19 | Allergen-enhanced thrombomodulin (blood dendritic cell antigen 3, CD141) expression on dendritic cells is associated with a T H 2-skewed immune response显示文摘 | Stephanie T. Yerkovich Marjut Roponen Miranda E. Smith Kathy McKenna Anthony Bosco Lily S. Subrata Emilie Mamessier Matthew E. Wikstr?m Peter Le Souef Peter D. Sly Patrick G. Holt John W. Upham | 2009 | The Journal of Allergy and Clinical Immunology2009，，1： | 1 |
| 20 | Evaluation of the adaptation of zirconia-based fixed partial dentures using micro- CT technology显示文摘 | Borba M Miranda WG Jr Cesar PF | 2013 | Braz Oral Res2013，27，5： | 1 |
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