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| 1 | Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease显示文摘AIM: To evaluate the safety and feasibility of bone marrow cell (BMC) transplantation in patients with chronic liver disease on the waiting list for liver transplantation. METHODS: Ten patients (eight males) with chronic liver disease were enrolled to receive infusion of autologous bone marrow-derived cells. Seven patients were classified as Child-Pugh B and three as Child-Pugh C. Baseline assessment included complete clinical and laboratory evaluation and abdominal MRI. Approximately 50 ml of bone marrow aspirate was prepared by centrifugation in a ficoll-hypaque gradient. At least of 100 millions of mononuclear-enriched BMCs were infused into the hepatic artery using the routine technique for arterial chemoembolization for liver tumors. Patients were followed up for adverse events up to 4 mo. RESULTS: The median age of the patients was 52 years (range 24-70 years). All patients were discharged 48 h after BMC infusion. Two patients complained ofmild pain at the bone marrow needle puncture site. No other complications or specific side effects related to the procedure were observed. Bilirubin levels were lower at 1 (2.19 ± 0.9) and 4 mo (2.10 ± 1.0) after cell transplantation that baseline levels (2.78 ± 1.2). Albumin levels 4 mo after BMC infusion (3.73 ± 0.5) were higher than baseline levels (3.47 ± 0.5). International normalized ratio (INR) decreased from 1.48 (SD = 0.23) to 1.43 (SD = 0.23) one month after cell transplantation. CONCLUSION: BMC infusion into hepatic artery of patients with advanced chronic liver disease is safe and feasible. In addition, a decrease in mean serum bilirubin and INR levels and an increase in albumin levels are observed. Our data warrant further studies in order to evaluate the effect of BMC transplantation in patients with advanced chronic liver disease. | Andre Castro lyra Milena Botelho Pereira Soares luiz Flavio Maia da Silva Marcos Fraga Fortes André Goyanna Pinheiro Silva Augusto César de Andrade Mota Sheilla A Oliveira Eduardo lorens Braga Wilson Andrade de Carvalho Bernd Genser Ricardo Ribeiro dos Santos luiz Guilherme Costa lyra | 2007 | World Journal of Gastroenterology2007，13，7： | 21 |
| 2 | Factors predicting poor prognosis in ischemic colitis显示文摘瞄准:决定临床、分析、内视镜的因素与有关是化学家大肠炎(IC ) 严厉。方法:85 个病人的一个总数从 1996 年 1 月在回顾的研究被注册到 2004 年 5 月。有 53 女性和 32 男性(年龄 74.6+/-9.4 年,范围 45-89 年) 。病人作为 IC 被诊断。下列变量包括年龄,性别,从到承认的症状的外观的时间的经期,病历,药,凳子频率,临床的症状和症状被分析,验血(血克和基本生物化学的侧面) ,和内视镜的调查结果。病人们在温和 IC 组和严重 IC 组(外科或死亡) 被划分。质的变量用 chi 平方测试被分析,参量的数据用学生的 t (P<0.05 ) 被分析。结果:温和 IC 组 69 个病人被在于(42 女性和 27 男性,平均年龄 74.7+/-12.4 年) 。严重 IC 组由 16 个病人组成(11 女性和 5 男性,平均 73.8+/-12.4 年的年龄) 。因为麦克匪特斯氏疗法(没有外科) 的失败,一个病人死了, 15 个病人经历了外科(6 在内视镜的诊断以后并且 9 在 peroperatory 以后诊断) 。85 个病人(9.6%) 中的八个死了,其它被跟随在上面作为为 9.6+/-3.5 瞬间的门诊病人。人口统计的数据,病历,药和凳子频率在两个组(P>0.05 ) 是类似的。说正经的有病的病人比稍微有病的病人有更少的便血(37.5% 对 86.9% , P = 0.000 ) 。更多的心悸亢进(45.4% 对 10.1% , P = 0.011 ) 并且假腹膜炎的更高的流行签名(75% 对 5.7% , P = 0.000 ) 当腹的疼痛的存在和紧张在二个组之间是类似的时,在严重 IC 组被观察。当承认时,有严重 IC 的二个病人有吃惊。关于分析数据,更严重有病的病人被发现比略微有病的病人有贫血症和血钠过少(37.5% 对 10.1% , P = 0.014 和 46.6% 对 14.9% , P = 0.012,分别地) 。狭窄是那比在稍微有病的病人更经常出现在严重有病的病人的唯一的内视镜的发现(66.6% 对 17.3% , P = 0.017 ) 。结论:能预言 IC 的差的预后是便血,心悸亢进和假腹膜炎,贫血症和血钠过少和狭窄的缺席的因素。 | Ramón A■ón Marta Maia Boscá Vicente Sanchiz Joan Tosca Pedro Almela Cirilo Amorós Adolfo Benages | 2006 | World Journal of Gastroenterology2006，12，30： | 21 |
| 3 | Crohn's disease of esophagus,stomach and duodenum显示文摘Crohn's disease with involvement of the esophagus, stomach and duodenum has a prevalence of 0.5% to 4% in symptomatic adult patients, but some studies have shown that these results may be underestimated, since upper gastrointestinal endoscopy is not performed routinely in the initial evaluation of the disease in adult patients, as it is in the pediatric population. In general, involvement of the upper gastrointestinal tract in Crohn's disease occurs concomitantly with involvement of the lower gastrointestinal tract. The diagnosis depends on clinical,endoscopic, histological and radiological evaluation. The presence of aphthoid ulcers, longitudinal ulcers, bamboo-joint-like appearance, stenoses and fistulas are endoscopic findings suggestive of the disease, and it is important to exclude the presence of Helicobacter pylori infection. The primary histological findings,which facilitate the diagnosis, are the presence of a chronic inflammatory process with a predominance of lymphoplasmacytic cells and active focal gastritis. The presence of epithelioid granuloma, although less frequent, is highly suggestive of the disease in the absence of chronic granulomatous disease. Treatment should include the use of proton pump inhibitors associated with corticosteroids,immunomodulators and biological therapy according to the severity of the disease. | Andréa Maia Pimentel Raquel Rocha Genoile Oliveira Santana | 2019 | World Journal of Gastrointestinal Pharmacology and Therapeutics2019，10，2： | 9 |
| 4 | 胚胎巨噬细胞和小胶质细胞消融调控小鼠胚胎背根神经节感觉神经元的发育显示文摘众所周知,小胶质细胞可以调节中枢神经系统发育的一些方面。在第11.5天的小鼠胚胎中的小胶质细胞定殖脊髓时,它们与背根神经节感觉神经元(SN)的生长中心轴突相互作用,这表明它们可能在SN发育中发挥一定功能。为了解决这个问题,我们使用缺乏胚胎巨噬细胞(PU.1敲除小鼠)和免疫细胞消融的小鼠胚胎分析胚胎巨噬细胞消融对SNs早期发育的影响。我们发现,除小胶质细胞外,胚胎巨噬细胞还与来自第11.5天的小鼠胚胎的原肌球蛋白受体激酶(Trk)C+感觉神经元,TrkB+感觉神经元和TrkA+感觉神经元外周神经突产生交联。免疫细胞剥夺会导致第11.5天的小鼠胚胎的TrkC+感觉神经元和TrkB+感觉神经元初始数量的减少,这与其发育细胞死亡(DCD)的改变有关联的可能性较小,因为其后在第12.5天的胚胎中的数量有短暂增加。在分析的发育期(第11.5~15.5天),它也导致TrkA+感觉神经元数量减少,尽管我们没有观察到他们的DCD有任何变化。与神经元祖细胞可能存在一致性的脑脂肪酸结合蛋白(BFABP-)阴性细胞的增殖在第11.5天的胚胎中增加,而它们的增殖在第12.5天的胚胎减少,这可部分解释从11.5 d观察到的SN亚型产生的改变。此外,我们观察到在缺乏胚胎巨噬细胞的情况下神经胶质细胞祖细胞(BFABP+细胞)增殖的改变。我们的数据表明,胚胎巨噬细胞和小胶质细胞消融调控SN的发育。 | Angelim MKSC Maia LMSS Mouffle C Ginhoux F Low D Amancio-Dos-Santos A Makhoul J Le Corronc H Mangin JM Legendre P 聂昊(编译) | 2018 | 神经损伤与功能重建2018，13，9： | 2 |
| 5 | Synthesis of utility systems by simulated显示文摘 | Maia L O A Vidal L A Qassim R Y | 1995 | Comp & Chem Eng1995，19，： | 1 |
| 6 | Infinitely many nodal solutions for a weakly coupled nonlinear Schr6dinger system 显示文摘 | Maia L A Montefuseo E Pellacci B | 2008 | Communications in Contemporary Mathematics2008，10，5： | 1 |
| 7 | Tracheal lipoma mimicking obstructive lung disease显示文摘 | MOTA V T MAIA J G BARBOSA A T | 2010 | J Bras Pneumol2010，36，1： | 1 |
| 8 | Synthesis of utility systems with variable demands using simulated annealing显示文摘 | Maia L O A Vidal L A Qassim R Y | 1997 | Comp & Chem Eng1997，21，： | 1 |
| 9 | A review of vibration-based structural health monitoring with special emphasis on composite materials 显示文摘 | Montalv-o D Maia N M M Ribeiro A M R | 2006 | Shock and Vibration Digest2006，38，4： | 1 |
| 10 | Perspective on fluid and solid dynamics in different pars plana vitrectomy systems显示文摘 | Magalh(a)es O Jr Maia M Rodrigues EB | | 0，，： | 1 |
| 11 | Quality Assurance Re- quirements in Produce Processing 显示文摘 | DA CRUZ G CENCI A & MAIA A | 2006 | Trends in Food Science & Technology2006，17，8： | 1 |
| 12 | The use of transmissibility properties to estimate FRFs on modified structures 显示文摘 | Almeida R A B Urgueira A P V Maia N M M | 2010 | Shock and Vi- bration2010，17，4： | 1 |
| 13 | The transmissibility concept in multiple degrees of freedom systems 显示文摘 | Maia N M M Silva J M M Ribeiro A M R | 2001 | Mechanical Systems and Signal Processing2001，15，1： | 1 |
| 14 | Bone mineral density and depression:a community study in women显示文摘 | Coelho R Silva C Maia A | 1999 | J Psychosom Res1999，46，1： | 1 |
| 15 | Immunological evaluation of a 26 ku antigen from Taenia solium larvae for specific immunodiagnosis of human neurocysticercosis 显示文摘 | Ev L V Maia A A Pianetti G | 1999 | Parasitol Res1999，85，2： | 1 |
| 16 | Environmental behavior and analysis of veterinary and human drugs in soils,sediments and sludge显示文摘 | SILVIA D C MAIA J LOPEZ A | | 0，，06： | 1 |
| 17 | On the use of the transmissibility concept for the evaluation of frequency response functions显示文摘 | Urgueira A P V Almeida R A B Maia N M M | 2011 | Mechanical Systems and Signal Processing2011，25，3： | 1 |
| 18 | Insertion of mirena after endometrial resection in patients with adenomyosis显示文摘 | Maia HI Maltez A Coelho G | 2003 | J Am Assoc Gynecol Laparosc2003，10，4： | 1 |
| 19 | Evolution of Peroxide-induced Thermomechanical Degradation of Polypropylene along the Extruder显示文摘 | A V Machado J M Maia S V Canevarolo | 2004 | J Appl Polym Sci2004，91，4： | 1 |
| 20 | Solutions for a resonant elliptic system with coupling in RN显示文摘 | Furtado M F Maia L A Silva E A B | | 0，，： | 1 |
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