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| 1 | Endoscopic approach to malignant strictures at the hepatic hilum显示文摘Hilar tumors have proven to be a challenge to treat and manage because of their poor sensitivity to conventional therapies and our inability to prevent or to detect early tumor formation. Endoscopic stent drainage has been proposed as an alternative to biliary-enteric bypass surgery and percutaneous drainage to palliate malignant biliary obstruction. Prosthetic palliation of patients with malignant hilar stenoses poses particular difficulties, especially in advanced lesions (type n lesions or higher). The risk of cholangitis after contrast injection into the biliary tree in cases where incomplete drainage is achieved is well known. The success rate of plastic stent insertion is around 80% in patients with proximal tumors. Relief of symptoms can be achieved in nearly all patients successfully stented. | Giovanni D De Palma Stefania Masone Maria Rega Immacolata Simeoli Francesca Salvatori Saverio Siciliano Francesco Maione Valerio Girardi Marta Celiento Giovanni Persico | 2007 | World Journal of Gastroenterology2007，13，30： | 8 |
| 2 | Bsm I(rs1544410) and Fok I(rs2228570) vitamin D receptor polymorphisms, smoking, and body mass index as risk factors of cutaneous malignant melanoma in northeast Italy显示文摘Objective:To investigate whether vitamin D receptor gene(VDR)Bsm I-rs1544410 and Fok I-rs2228570 polymorphisms,smoking duration,and body mass index(BMI)are risk factors for cutaneous melanoma,especially metastatic melanoma.Methods:We studied 120 cutaneous melanoma cases[68 stage I and II non-metastatic melanoma(NMet M)patients,plus 52Stage III and IV metastatic melanoma(Met M)patients],and 120 matching healthy controls from northeast Italy.VDR polymorphisms were measured by restriction fragment length polymorphism analysis.Absence or presence of Bsm I and Fok I restriction sites was denoted by'B'and'F'or by'b'and'f,'respectively.Results:VDR-Bsm I bb genotype was more frequent among Met M(32.7%)than among NMet M cases(13.2%),with odds ratio(OR)=3.18.Comparison of all melanoma patients vs healthy controls showed that the following biomarkers were at risk:≥20 years of smoking(OR=2.43);≥20 years of smoking combined with bb(OR=4.78),Bb+bb(OR=2.30),Ff(OR=3.04),and Ff+ff(OR=3.08);obesity(BMI>30Conclusions:Risk factors for cutaneous Met M include two VDR polymorphisms combined with smoking duration and obesity.Results suggest gene-environment implications in melanoma susceptibility and severity.Future studies in larger cohorts and in subjects with different genetic background are warranted to extend our findings. | Sabina Cauci Vincenzo Maione Cinzia Buligan Martina Linussio Diego Serraino Giuseppe Stinco | 2017 | Cancer Biology & Medicine2017，14，3： | 3 |
| 3 | In-vivo characterization of DALM in ulcerative colitis with high-resolution probe-based confocal laser endomicroscopy显示文摘Recently,the use of confocal laser endomicroscopy(CLE) in the diagnosis of chronic ulcerative colitis(CUC) was reported.In this brief report we aimed to assess the application of probe-based CLE to characterize colonic mucosa and dysplasia in CUC.The study involved a patient presenting long-standing CUC.Confocal imaging of both the inflamed mucosa,a circumscribed lesion(dysplasiaassociated lesional mass),and adjacent colonic mucosa are demonstrated and the correlation between the CLE and histological images.Inflamed mucosa and dysplasia showed specific alteration of crypt architecture,cellular infiltration,and vessel architecture with an excellent correlation between CLE and standard histological examination. | Giovanni D De Palma Stefania Staibano Saverio Siciliano Francesco Maione Maria Siano Dario Esposito Giovanni Persico | 2011 | World Journal of Gastroenterology2011，17，5： | 3 |
| 4 | Inhibition of angiogenesis by recombinant human platelet factor- 4 and related peptides 显示文摘 | Maione TE Gray GS Petro J | 1990 | Science1990，247，： | 2 |
| 5 | Renal Hemodynamic Effect of Sodium-Glucose Cotransporter 2 Inhibition in Patients With Type 1 Diabetes Mellitus显示文摘 | David Z.I. Cherney Bruce A. Perkins Nima Soleymanlou Maria Maione Vesta Lai Alana Lee Nora M. Fagan Hans J. Woerle Odd Erik Johansen Uli C. Broedl Maximilian von Eynatten | 2014 | Circulation2014，，： | 2 |
| 6 | Association Between a Polymorphism in Cannabinoid Receptor 2 and Severe Necroinflammation in Patients With Chronic Hepatitis C显示文摘 | Nicola Coppola Rosa Zampino Giulia Bellini Margherita Macera Aldo Marrone Mariantonietta Pisaturo Adriana Boemio Bruno Nobili Giuseppe Pasquale Sabatino Maione Luigi Elio Adinolfi Laura Perrone Evangelista Sagnelli Emanuele Miraglia Del Giudice Francesca | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 2 |
| 7 | Autism Spectrum Disorders: Is Mesenchymal Stem Cell Personalized Therapy the Future?显示文摘 | Dario Siniscalco Anna Sapone Alessandra Cirillo Catia Giordano Sabatino Maione Nicola Antonucci Ken-ichi Isobe | 2012 | Journal of Biomedicine and Biotechnology2012，，： | 2 |
| 8 | Contrast-free endoscopic stent insertion in malignant biliary obstruction显示文摘AIM: To present a case series of MRCP-guided endoscopic biliary stent placement, performed entirely without contrast injection. METHODS: Contrast-free endoscopic biliary drainage was attempted in 20 patients with malignant obstruction, unsuitable for resection on the basis of tumor extent or medical illness. MRCP images were used to confirm the diagnosis of tumor, to exclude other biliary diseases and to demonstrate the stenoses as well as dilation of proximal liver segments. The procedure was carried out under conscious sedation. Patients were placed in the left lateral decubitus position. The endoscope was inserted, the papilla identified and cannulated by a papillotome. A guide wire was inserted and guided deeply into the biliary tree, above the stenosis, by fluoroscopy. A papillotomy approximately 1 cm. long was performed and the papillotome was exchanged with a guiding-catheter. A 10 Fr, Amsterdam-type plastic stent, 7 to 15 cm long, was finally inserted over the guide wire/ guiding catheter by a pusher tube system. RESULTS: Successful stent insertion was achieved in all patients. There were no major complications. Successful drainage, with substantial reduction in bilirubin levels, was achieved in all patients. CONCLUSION: This new method of contrast-free endoscopic stenting in malignant biliary obstruction is a safe and effective method of palliation. However, a larger, randomized study comparing this new approach with the standard procedure is needed to confirm the findings of the present study. | Giovanni D De Palma Giovanni Lombardi Maria Rega Immacolata Simeoli Stefania Masone Saverio Siciliano Francesco Maione Francesca Salvatori Antonio Balzano Giovanni Persico | 2007 | World Journal of Gastroenterology2007，13，29： | 2 |
| 9 | Intra-brain microinjection of human mesenchymal stem cells decreases allodynia in neuropathic mice显示文摘 | Dario Siniscalco Catia Giordano Umberto Galderisi Livio Luongo Nicola Alessio Giovanni Bernardo Vito Novellis Francesco Rossi Sabatino Maione | 2010 | Cellular and Molecular Life Sciences2010，，4： | 2 |
| 10 | New insights in drug development for the non - small cell lung cancer therapy 显示文摘 | GRIDELLI C ROSSI A MAIONE P | 2008 | Front Biosci2008，13，： | 1 |
| 11 | Adjuvant chemotherapy in eldery patients with non-small-cell lung can cer显示文摘 | Maione P Comunale D | 2007 | Canctr Control2007，14，1： | 1 |
| 12 | Comparing digraph and Petri net approaches to deadlock avoidance in FMS显示文摘 | FANTI M P MAIONE B TURCHIANO B | 2000 | IEEE Trans on Syst Man Cybern B Cybernetics2000，30，5： | 1 |
| 13 | Interleukin-17A exacerbates ferric chloride-induced arterial thrombosis in rat carotid artery 显示文摘 | Maione F Parisi A Caiazzo E | 2014 | Int J Inflam2014，2014，24： | 1 |
| 14 | Overcoming resistance to tar- geted therapies in NSCLC:current approaches and clinical application 显示文摘 | Maione P Sacco PC Sgambato A | 2015 | Ther Adr Med Oncol2015，7，5： | 1 |
| 15 | Treatment of small cell lung cancer in elderly显示文摘 | Rossi A Maione P Colantuoni G | 2005 | Oncologist2005，10，6： | 1 |
| 16 | Advantage of Eradication Therapy for Helicobacter pylori Before Kidney Transplantation in Uremic Patients显示文摘 | G. Cocchiara M. Romano G. Buscemi C. Maione S. Maniaci G. Romano | 2007 | Transplantation Proceedings2007，，10： | 1 |
| 17 | Cetuximab and other anti-epidermal growth factor receptor monoclonal antibodies in the treatment of non-small cell lung cancer显示文摘 | Gridelli C Maione P Ferrara ML | 2009 | Oncologist2009，14，6： | 1 |
| 18 | Combining trgeted therapies and drugs with multiple targets in the treatment of NSCLC 显示文摘 | Maione P Gridelli C Troiani T | 2006 | Oncologist2006，11，3： | 1 |
| 19 | Cisplatin plus gemcitabine or vinorelbine for elderly patients with advanced non small - cell lung cancer: The MILES - 2P studies 显示文摘 | Gridelli C Maione P Illiano A | 2007 | J Clin Oncol2007，25，： | 1 |
| 20 | Echocardiographic alterations in systemic sclerosis: a longitudinal study 显示文摘 | Maione S Cuomo G Giunta A | 2005 | Semin Arthritis Rheum2005，34，： | 1 |
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