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| 1 | Implication of the intestinal microbiome in complications of cirrhosis显示文摘The intestinal microbiome(IM) is altered in patients with cirrhosis,and emerging literature suggests that this impacts on the development of complications.The Pub Med database was searched from January 2000 to May 2015 for studies and review articles on the composition,pathophysiologic effects and therapeutic modulation of the IM in cirrhosis.The following combination of relevant text words and MeS H terms were used,namely intestinal microbiome,microbiota,or dysbiosis,and cirrhosis,encephalopathy,spontaneous bacterial peritonitis,hepatorenal syndrome,variceal bleeding,hepatopulmonary syndrome,portopulmonary hypertension and hepatocellular carcinoma.The search results were evaluated for pertinence to the subject of IM and cirrhosis,as well as for quality of study design.The IM in cirrhosis is characterized by a decreased proportion of Bacteroides and Lactobacilli,and an increased proportion of Enterobacteriaceae compared to healthy controls.Except for alcoholic cirrhosis,the composition of the IM in cirrhosis is not affected by the etiology of the liver disease.The percentage of Enterobacteriaceae increases with worsening liver disease severity and decompensation and is associated with bacteremia,spontaneous bacterial peritonitis and hepatic encephalopathy.Lactulose,rifaximin and Lactobacillus-containing probiotics have been shown to partial y reverse the cirrhosis associated enteric dysbiosis,in conjunction with improvement in encephalopathy.The IM is altered in cirrhosis,and this may contribute to the development of complications associated with end-stage liver disease.Therapies such as lactulose,rifaximin and probiotics may,at least partially,reverse the cirrhosisassociated changes in the IM.This,in turn,may prevent or alleviate the severity of complications. | Mamatha Bhat Bianca M Arendt Venkat Bhat Eberhard L Renner Atul Humar Johane P Allard | 2016 | World Journal of Hepatology2016，8，27： | 13 |
| 2 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 3 | Continuing episodes of pain in recurrent acute pancreatitis: Prospective follow up on a standardised protocol with drugs and pancreatic endotherapy显示文摘AIM To assess the outcomes of drug therapy(DT)followed by pancreatic endotherapy for continuing painful episodes in recurrent acute pancreatitis.METHODS DT comprised of pancreatic enzymes and antioxidants failing which,endotherapy(ET;pancreatic sphincterotomy and stent placement)was done.The frequency of pain,its visual analogue score(VAS),quality of life(Qo L),serum C peptide and faecal elastase were compared between baseline and after 1 year of follow up in all patients and in the two subgroups on DT and ET.Response was defined as at least 50%reduction in the severity of pain to below a score of 5.RESULTS Of the thirty nine patients analysed,21(53.9%)responded to DT and 18(46.1%)underwent ET.The VAS for pain(7.0±2.0 vs 1.3±2.5,P<0.001)and the number of days with pain per month decreased[1.0(1.0,2.0)vs 1.0(0.0,1.0),P<0.001],and the Qo L scores[55.0(44.0,66.0)vs 38.0(32.00,51.00),P<0.01]improved significantly during follow up.Similar significant improvements were seen in patients in the subgroups of DT and ET except for Qo L in ET.The serum C-peptide(P=0.001)and FE(P<0.001)levels improved significantly in the entire group and in the two subgroups of patients except for the C peptide levels in patients on DT.CONCLUSION A standardised protocol of DT,followed by ET decreased the intensity and frequency of pain in recurrent acute pancreatitis,enhanced Qo L and improved pancreatic function. | C Ganesh Pai M Ganesh Kamath Mamatha V Shetty Annamma Kurien | 2017 | World Journal of Gastroenterology2017，23，19： | 2 |
| 4 | Geochemistry of fluoride rich groundwater in Kolar and Tumkur显示文摘 | Mamatha P Sudhakar M | 2010 | Environmental Earth Sciences2010，61，1： | 1 |
| 5 | Geochemistry of fluoride rich groundwater in Kolar and Tumkur Districts of Karnataka显示文摘 | Mamatha P Sudhakar M R | 2010 | Environmental Earth Sciences2010，61，1： | 1 |
| 6 | Asymmetric dimethylarginine as a risk marker for early-onset ischemic stroke in indian population显示文摘 | Mamatha SN Nagaraja D Philip M | 2011 | Clin Chim Acta2011，412，12： | 1 |
| 7 | Geochemistry of fluoride rich groundwater in Kolar and Tumkttr Districts of Karnataka显示文摘 | Mamatha P Sudhakar M R | 2010 | Environmental Earth Sciences2010，61，1： | 1 |
| 8 | Mechanochemical preparation and investigation of properties of magnesium calcium and lithium-magnesium alanates显示文摘 | Mamatha M Bogdanovic B Felderhoff M | 2006 | Journal of Alloys and Compounds2006，407，： | 1 |
| 9 | Targeting JAK2 in the therapy of myeloproliferative neoplasms显示文摘 | Mamatha M Reddy Anagha Deshpande Sattler M | 2012 | Expert Opin Ther Targets2012，16，3： | 1 |
| 10 | Laboratory Characterization of Tyre Crumbs Soil Mixture for Developing Low Cost Damping Materials显示文摘 | Anbazhagan P Mamatha M Soumyashree P | 2011 | Intemational Journal of Earth Sciences and Engineering2011，4，6： | 1 |
| 11 | Laboratory Characterization of Tyre Crumbs Soil Mixture for Developing Low Cost Damping Materials显示文摘 | Anbazhagan P Mamatha M Soumyashree P | 2011 | International Journal of Earth Sciences and Engineering2011，4，6： | 1 |
| 12 | Oral cancer in vivo gene expression profiling assisted by laser capture microdissection and microarray analysis显示文摘 | Ilias A Mamatha M Xue Z | 2001 | Onco Gene2001，20，43： | 1 |
| 13 | Geochemistry of fluoride rich groundwater in Kolar and Tumkur Districts of Kamataka 显示文摘 | P Mamatha Sudhakar M Rao | 2010 | Environ Earth Sci2010，61，： | 1 |
| 14 | A Survey on Data Storage and Security in Cloud Comput- ing显示文摘 | Spoorthy V Mamatha M Kumar B S | 2014 | 2014，，： | 1 |
| 15 | Evaluation of the flavor quality of pepper(Piper nigrum L)cultivars by GC-MS, electronic nose and sensory analysis techniques显示文摘 | Mamatha B S Prakash M Nagarajan S | 2008 | Journal ofSensory Studies2008，23，： | 1 |
| 16 | Mechanochemical preparation and investigation of properties of magnesium,calcium and lithium-magnesium alanates 显示文摘 | Mamatha M Bogdanovic B Felderhoff M | 2006 | Journal of Alloys and Compounds2006，407，： | 1 |
| 17 | Geochemistry of fluoride rich groundwater in Kolar and Tumkur Districts of Karnataka显示文摘 | Mamatha P Sudhakar M R | 2010 | Environmental Earth Sciences2010，61，1： | 1 |
| 18 | Mechanochemical preparation and investigation of properties of magnesium, calcium and lithi- um-magnesium alanates 显示文摘 | Mamatha M Bogdanovi6 B Felderhoff M Pommerin A Schmidt W Schtlth F Weidenthaler C | 2006 | Journal of Alloys and Compounds2006，407，12： | 1 |
| 19 | Asymmetric dimethylargi- nine as a risk marker for early-onset ischemic stroke in indian pop- ulation显示文摘 | Mamatha SN Nagaraja D Philip M | 2011 | Clin Chim Acta2011，412，12： | 1 |
| 20 | Cytosolic iron superoxide dismutase is a part of the triacylglycerol biosynthesis complex in oleaginous yeast 显示文摘 | Sumana Raychaudhuri Mamatha M Reddy Naveen R Rajkumar | 2003 | Biochem J2003，372，： | 1 |
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