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| 1 | Regulated upon activation,normal T cell expressed and secreted(RANTES)levels in the peripheral blood of patients with Alzheimer’s disease显示文摘Alzheimer’s disease(AD)is the most common type of dementia,but it is very difficult to diagnose with certainty,so many AD studies have attempted to find early and relevant diagnostic markers.Regulated upon activation,normal T cell expressed and secreted(RANTES,also known as C-C chemokine ligand)is a chemokine involved in the migration of T cells and other lymphoid cells.Changes in RANTES levels and its expression in blood or in cerebrospinal fluid have been reported in some neurodegenerative diseases,such as Parkinson’s disease and multiple sclerosis,but also in metabolic diseases in which inflammation plays a role.The aim of this observational study was to assess RANTES levels in peripheral blood as clinical indicators of AD.Plasma levels of RANTES were investigated in 85 AD patients in a relatively early phase of AD(median 8.5 months after diagnosis;39 men and 46 women;average age 75.7 years),and in 78 control subjects(24 men and 54 women;average age 66 years).We found much higher plasma levels of RANTES in AD patients compared to controls.A negative correlation of RANTES levels with age,disease duration,Fazekas scale score,and the medial temporal lobe atrophy(MTA)score(Scheltens’s scale)was found in AD patients,i.e.,the higher levels corresponded to earlier stages of the disease.Plasma RANTES levels were not correlated with cognitive scores.In AD patients,RANTES levels were positively correlated with the levels of pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-α,which is consistent with the wellknown fact that AD is associated with inflammatory processes.RANTES levels were also positively correlated with insulin levels in AD patients,with insulin resistance(HOMA-R)and pancreatic beta cell function(HOMA-F).This study evaluated several clinical and metabolic factors that may affect plasma levels of RANTES,but these factors could not explain the increases in RANTES levels observed in AD patients.Plasma levels of RANTES appear to be an interesting peripheral marker for early stages of AD.The study was approved by the Ethics Committee of Institute of Endocrinology,Prague,Czech Republic on July 22,2011. | Gabriela Vacínová Daniela Vejražkova Robert Rusina Iva Holmerová Hana Vaňková Eva Jarolímová Josef Včelák Běla Bendlová Markéta Vaňková | 2021 | Neural Regeneration Research2021，16，4： | 3 |
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| 4 | A convenient synthesis of 3-alkylthiophenes显示文摘 | Pham C V Mark H B Zimmer H | 1986 | Synthetic Communications1986，16，6： | 1 |
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| 6 | A convenient synthesis of 3-alkylthiophenes显示文摘 | Mark H B Zimmer H | 1986 | Synthetic Communications1986，16，6： | 1 |
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| 8 | Evaluation and analysis of soil washing for seven lead-contaminated soils显示文摘 | Mark R M William H Y | 1997 | Journal of Environmental Engineering1997，3，： | 1 |
| 9 | Disentangling the drivers of β diversity along latitudinal and elevational gradients 显示文摘 | Kraft NJB Comita LS Chase JM Sanders NJ Swenson NG Crist TO Stegen JC Mark V Brad B Anderson MJ | 2011 | Science2011，333，6050： | 1 |
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| 12 | The human drug metabolizing cytochromes P450显示文摘 | Seven A W Mark V B Barbara J R | 1996 | J Phannacokinet Biopharm1996，24，5： | 1 |
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| 14 | PAHs in the Fraser River basin: a critical appraisal of PAH ratios as indicators of PAIl source and composition 显示文摘 | Mark B Y Robie W M Roxanne V | 2002 | Organic Geochemistry2002，33，： | 1 |
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| 16 | The use of feed forward neural networks for machine vision calibration显示文摘 | Mark B L Cihan H D Mahesh V | 1999 | Production Economics1999，，1： | 1 |
| 17 | Molecular modeling and structure studies of LARC-CPI semicrystalline polyimide显示文摘 | Mark V B Cheng Yaoyi Pradnya Nagarkart | 1997 | Polymer1997，38，12： | 1 |
| 18 | Innovative Mthods for sludge characterization in biological phosphorus removal systems显示文摘 | DAMIR B MARK C M LOOSDRECHT V | 1999 | Wat sci Tech1999，，39： | 1 |
| 19 | Associations of polycyclic organic matter in outdoor air with decreased birth weight:a pilot cross-sectional analysis显示文摘 | Zdravko P V Mark G R Judith B K | 2001 | Journal of Toxicology and Environmental Health2001，64，： | 1 |
| 20 | Insider trading, earnings quality, and accrual mispricing 显示文摘 | MARK E V MESSOD D B | 2002 | The Accounting Review2002，77，4： | 1 |
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