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| 1 | Direct-fed microbes: A tool for improving the utilization of low quality roughages in ruminants显示文摘For many years, ruminant nutritionists and microbiologists have been interested in manipulating the microbial ecosystem of the rumen to improve production efficiency of different ruminant species. Removal and restriction of antibiotics subtherapeutic uses from ruminant diets has amplified interest in improving nutrient utilization and animal performance and search for more safe alternatives. Some bacterial and fungal microorganisms as a direct-fed microbial(DFM) can be the most suitable solutions. Microorganisms that are commonly used in DFM for ruminants may be classified mainly as lactic acid producing bacteria(LAB), lactic acid utilizing bacteria(LUB), or other microorganism's species like Lactobacillus, Bifidobacterium, Enterococcus, Streptococcus, Bacillus, Propionibacterium, Megasphaera elsdenii and Prevotellabryantii, in addition to some fungal species of yeast such as Saccharomyces and Aspergillus. A definitive mode of action for bacterial or fungal DFM has not been established; although a variety of mechanisms have been suggested. Bacterial DFM potentially moderate rumen conditions, and improve weight gain and feed efficiency. Fungal DFM may reduce harmful oxygen from the rumen, prevent excess lactate production, increase feed digestibility, and alter rumen fermentation patterns. DFM may also compete with and inhibit the growth of pathogens, immune system modulation, and modulate microbial balance in the gastrointestinal tract. Improved dry matter intake, milk yield, fat corrected milk yield and milk fat content were obtained with DFM administration. However, the response to DFM is not constant; depending on dosages, feeding times and frequencies, and strains of DFM. Nonetheless, recent studies have supported the positive effects of DFM on ruminant performance. | Mona M Y Elghandour Abdelfattah Z M Salem Jose S Martínez Castaeda Luis M Camacho Ahmed E Kholif Juan C Vázquez Chagoyán | 2015 | Journal of Integrative Agriculture2015，14，3： | 7 |
| 2 | P2X4受体对活化的小胶质细胞的调控作用显示文摘小胶质细胞是中枢神经系统内的免疫细胞,当脑组织出现损伤时,小胶质细胞被激活,对脑组织起到保护作用。在自身免疫性脑脊髓炎模型大鼠和视神经脊髓炎患者体内,均观察到在脊髓炎性病灶及小胶质细胞内,P2X4受体表达上调。本课题组进行在体和离体实验,用LPS活化小胶质细胞,观察P2X4受体在小胶质细胞炎性反应中的作用。膜片钳检测显示,在LPS激活的小胶质细胞内,P2X4受体活性增加。P2X4受体阻断剂可显著降低小胶质细胞的膜皱缩、TNFα的分泌、细胞形态的改变及LPS导致的小胶质细胞死亡。在体研究显示,LPS髓内注射后会诱发炎性反应,迅速导致小胶质细胞丢失;给予P2X4受体阻断剂可显著减少小胶质细胞的丢失,而P2X4受体激活剂则可显著增加小胶质细胞的丢失。海马齿状回的小胶质细胞特别容易被LPS诱导的炎症反应激活。注射LPS后2 h,位于海马齿状回的小胶质细胞即被激活,大约24 h后死亡,P2X4受体阻断剂可减少LPS诱导的小胶质细胞活化和死亡。上述数据提示,P2X4受体对于小胶质细胞的激活和存活有重要的调控作用。 | Vázquez-Villoldo N Domercq M Martín A Llop J Gómez-Vallejo V Matute C | 2014 | 神经损伤与功能重建2014，9，1： | 4 |
| 3 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | Ethanol production from enzymatic hydrolysates of sugarcane bagasse using recombinant xylose-utilising Saccharomyces cerevisiae显示文摘 | Mart?n C Galbe M Wahlbom C F | 2002 | Enzyme Microb Technol2002，31，3： | 1 |
| 5 | A modified AIDA protocol with anthracycline-based consolidation results in high antileukemic efficacy and reduced toxicity in newly diagnosed PML/RA Ralpha-positive acute promyelocytic leukemia显示文摘 | Sanz M A Martín G Rayón C | 1999 | PETHEMA group Blood1999，94，9： | 1 |
| 6 | Usefulness of a two-step PCR procedure for detection and identification of enterotoxigenic Staphylococci of bacterial isolates and food samples显示文摘 | Martín M C González-Hevia M A Mendoza M C | 2003 | Food Microbiology2003，20，5： | 1 |
| 7 | A phase I, dose - finding study of sunitinib combined with cisplatin and 5 - fluorouracil in patients with ad- vanced gastric cancer显示文摘 | G? MEZ- MART? N C1 SALAZAR R MONTAGUT C GIL- MART? N M | 2013 | Invest New Drugs2013，31，2： | 1 |
| 8 | Ethanol production from enzymatic hydrolysates of sugarcane bagasse using recombinant xylose-utilising Saccharomyces cerevisiae显示文摘 | Carlos Mart′?n Galbe M Wahlbom C F | 2002 | Enzyme and Microbial Technology2002，31，3： | 1 |
| 9 | Prognostic significance of progesterone receptor-positive tumor cells within immunohistochemically defined luminal A breast cancer显示文摘 | Prat A Cheang M C U Martín M | 2013 | J Clin Oncol2013，31，2： | 1 |
| 10 | aroA gene PCR-RFLP diversity pattems in Haemophilus parasuis and Actinobacillus species显示文摘 | Río M L Martín C B Navas J | 2006 | Res Vet Sci2006，80，1： | 1 |
| 11 | Intensive care adult patients with severe respiratory failure caused by influenza A(H1N1)v in Spain显示文摘 | Rello J Rodríguez A Ibaez P Socias L Cebrian J Marques A Guerrero J Ruiz-Santana S Marquez E Del Nogal-Saez F Alvarez-Lerma F Martínez S Ferrer M Avellanas M Granada R Maraví-Poma E Albert P SierraR Vidaur L Ortiz P Prieto del Portillo I Galván B León-Gil C H1N1SEMICYUC Working Group | 2009 | Crit Care2009，13，5： | 1 |
| 12 | Use of microperimetry to evaluate hydroxychloroquine and chloroquine retinal toxicity显示文摘 | Mart í nez-Costa L Victoria Iba(n)ez M Murcia-Bello C | 2013 | Can J Ophthalmol2013，48，5： | 1 |
| 13 | Metabolic syndrome, adiponectin, and cardiovascular risk in spain(The Segovia Study) :Impact of consensus societies criteria显示文摘 | Corbat n A A Mart nez L M T Fern ndez P C | 2013 | Metab Syndr Relat Disord2013，，： | 1 |
| 14 | Effectiveness of onboard application of 4-Hexylresorcinol in inhibiting melanosis in shrimp (Parapenaeus longirostris)显示文摘 | Montero P Martínez-álvarez O Gómez-Guillén M C | 2004 | Journal of Food Science2004，69，8： | 1 |
| 15 | A novel real-time polymerase chain reaction-based method for the detection and quantification of lactose-fermenting Enterobacteriaceae in the dairy and other food industries显示文摘 | Martín M C Martínez N del Rio B | 2010 | Journal of Dairy Science2010，93，3： | 1 |
| 16 | Antagonistic role of 9-lipoxygenase-derived oxylipins and ethylene in the control of oxidative stress,lipid peroxidation and plant defence显示文摘 | LóPEZ M A VICENTE J KULASEKARAN S VELLOSILLO T MARTíNEZ M IRIGOYEN M L CASCóN T BANNENBERG G HAMBERG M CASTRESANA C | 2011 | Plant Journal2011，67，： | 1 |
| 17 | Separation of asparaginase and trypsin by affinity chromatography combined with batchwise adsorption and columnwise desorption显示文摘 | Martín del vall E M Freitas S C Galán M A | 2002 | Process Biochem2002，38，： | 1 |
| 18 | Oxylipins produced by the 9-lipoxygenase pathway in Arabidopsis regulate lateral root developmentand defense response through a specific signaling cascade显示文摘 | VELLOSILLO T MARTíNEZ M LóPEZ M A VICENTE J CASCóN T DOLAN L HAMBERG M CASTRESANA C | 2007 | Plant Cell2007，19，： | 1 |
| 19 | Non- conventional techniques to obtain grapefruit jam 显示文摘 | Igual M Contreras C Mart I nez-Navarrete N | 2010 | Innovative Food Science & Emerging Technologies2010，11，2： | 1 |
| 20 | Determination of48 pesticides and their main metabolites in water samples byemploying sonication and liquid chromatography–tandem massspectrometry显示文摘 | Fenoll J Hellín P Martínez C M | 2011 | Talanta2011，85，97： | 1 |
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