|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features显示文摘Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome (ZES). ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal re?ux disease and occasional diarrhea. Genetically, nonhereditary (sporadic) gastrinomas are distinguished from hereditary gastrinomas, which are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. In general, duodenal gastrinomas are small and solitary if they are sporadic and multiple as well as hereditary. The sporadic gastrinomas occur in the duodenum or in the pancreas while the hereditary gastrinomas almost all occur in the duodenum. Our series of 77 sporadic duodenal neuroendocrine tumors (NETs) includes 18 patients (23.4%) with gastrinomas and ZES. Of 535 sporadic NETs in the pancreas collected from the NET archives of the departments of pathology in Zürich, Switzerland, and Kiel, Germany, 24 patients (4.5%) suffered from sporadic pancreatic gastrinomas and ZES. These NETs have to be distinguished fromtumors with immunohistochemical positivity for gastrin but without evidence of ZES. An additional 19 patients suffered from MEN1 and ZES. These patients showed exclusively duodenal gastrinomas, but not pancreatic gastrinomas. The prognosis of sporadic and MEN1- associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. In summary, sporadic and MEN1- associated gastrinomas in the duodenum and pancreas show different clinico-pathological and genetic features. The incidence of sporadic duodenal gastrin-producing tumors is increasing, possibly due to optimized diagnostic procedures. In contrast, pancreatic MEN1- associated gastrinomas seem to be extremely rare. A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas. | Martin Anlauf Nele Garbrecht Tobias Henopp Anja Schmitt Regina Schlenger Andreas Raffel Markus Krausch Oliver Gimm Claus F Eisenberger Wolfram T Knoefel Henning Dralle Paul Komminoth Philipp U Heitz Aurel Perren Günter Klppel | 2006 | World Journal of Gastroenterology2006，12，34： | 7 |
| 2 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 3 | Effects of salt andtemperature on proteolysis during ripening of Iberian ham 显示文摘 | Martin L C6rdoba J J Antequera T f | 1998 | Meat Science1998，49，： | 1 |
| 4 | Effect of a prepartum administration of monensin in a controlled-release capsule on apparent digestibilities and nitrogen utilization in transition dairy cows显示文摘 | Plaizier J C Martin A Duffield T F | | 0，，12： | 1 |
| 5 | Follow up studies on therespiratory pattern and total cholinesterase activities in dichlorvos-poisoned rats显示文摘 | Duarte T Martin C Baud F Jf | 2012 | Toxicoly Lett2012，213，2： | 1 |
| 6 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 7 | Synthesis and oxidation reactions of cycloheptatrienyl sulfones显示文摘 | Zhiwei T Yuahong C Martin F | 2000 | Tetrahedron Lett2000，41，41： | 1 |
| 8 | Multistage expansion planning for active distribution networks under demand and distributed generation uncertainties显示文摘 | BORGES C L T MARTINS V F | 2012 | International Journal of Electrical Power Energy Systems2012，36，1： | 1 |
| 9 | A survey on automatic text summarization 显示文摘 | Das D Martins A F T | 2007 | International Journal of Engineering2007，4，： | 1 |
| 10 | Covalent immobilization of cyclodextrin glucosyltransferase(CGTase)in activated silica and Sepharose显示文摘 | MARTIN M T PLOU F J ALCADE M | 2002 | Indian J Biochem Biophys2002，39，4： | 1 |
| 11 | Isoflurane,but not halothane,depresses c-Fos expression in rat spinal cord at concentrations that suppress reflex movement after supramaximal noxious stimulation显示文摘 | Jinks S L Antognini J F Martin J T | 2002 | Anesth Analg2002，95，： | 1 |
| 12 | Stepped-impedance lowpass filters with spurious pass-band suppression显示文摘 | J Garcia-Garcia J Bonache F Falcone J D Baena F Martin I Gil T Lopetegi M A G Laso A Marcotegui R Marques M Sorolla | 2004 | Electronic Letters2004，40，14： | 1 |
| 13 | Comparative study of Bifidobac-terium animalis, Escherichia coli, Lactobacillus casei and Saccharomycesboulardii probiotic properties 显示文摘 | Martins F S Silva A A Vieira A T | 2009 | Archives of Microbiology2009，191，62： | 1 |
| 14 | Active distribution network integrated planning incorporating distributed generation and load response uncertainties显示文摘 | MARTINS V F BORGES C L T | 2011 | IEEE Trans on Power Systems2011，26，4： | 1 |
| 15 | Vasospasm of the internal auditory artery : significance in cerebellopontine angle surgery显示文摘 | Mom T Telischi F Martin GK | 2000 | Am J Otol2000，21，： | 1 |
| 16 | Shotgun proteomic analysis of the unicellular alga Ostreococcus tauri显示文摘 | LE BIHAN T MARTIN S F | | 0，，10： | 1 |
| 17 | Active distribution net- work integrated planning incorporating distributed generation and load response uncertainties显示文摘 | V F Martins C L T Borges | 2011 | Power Systems IEEE Transactions on2011，26，4： | 1 |
| 18 | Effect of membrane permeability on survival oi hemodialysis patients显示文摘 | Locatelli F Martin Malo A llannedouche T | 2009 | J Am Soc Nephrol2009，20，： | 1 |
| 19 | Using sampling theory to build a more universal forest vegetation database显示文摘 | Martin F C Baggett T Wolfe T and Mita R | 2000 | Computers and Electronics in Agriculture2000，，3： | 1 |
| 20 | Active distribution network integrated planning incorporating distributed generation and load response uncertainties显示文摘 | Martins V F Borges C L T | 2011 | IEEE Transactions Power System2011，26，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员