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| 1 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016,22,13: | 9 |
| 2 | MR diffusion tensor imaging of white matter tract disruption in stroke at 3T显示文摘 | Gillard JH Papadakis NG Martin K | 2001 | Br J Radiol2001,74,6: | 1 |
| 3 | Therapeutic Monitoring of Vancomycin in Adult Patients:A Consensus Review of the American Society of Health-SystemPharmacists, the Infectious Diseases Society of America, and thesociety of Infectious Dis- eases Pharmacists显示文摘 | Martin JH Norris R Barras M | 2010 | Clin Biochem Rev2010,31,2: | 1 |
| 4 | Role of glucose and insulin resistance in development of type 2 diabetes mellitus:results of a follow-up study显示文摘 | Martin BC Warram JH Krowleski AS | 1992 | Lancet1992,340,8825: | 1 |
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| 6 | Therapeutic monitoring of vancomycin in adult patients:a consensus review of the American Society of Health-System Pharmacists,the Infectious Diseases Society of America,and the Society Of Infectious Diseases Pharmacists显示文摘 | Martin JH Norris R Barras M | 2010 | Clin Biochem Rev2010,31,1: | 1 |
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| 10 | MR diffusion tensor imaging of white matter tract disruption in stroke at 3T显示文摘 | Gillard JH Papadakis NG Martin K | 2001 | Br J Radiol2001,74,883: | 1 |
| 11 | Quality improvement guidelines for angiography , angioplasty, and stent placement in the diagnosis and treatment of renal artery, stenosis in adults显示文摘 | Martin LG Rundback JH Sacks D | 2003 | J Vasc Interv Radiol2003,14,: | 1 |
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| 13 | Corticospinal system developmentdepends on motor experience 显示文摘 | Martin JH Choy M Pullman S | 2004 | J Neurosci2004,24,9: | 1 |
| 14 | MR diffusion tensor imaging of white matter tract disruption in stroke at 3T 显示文摘 | Papadakis NG Martin K | 2001 | The British Journal of Radiology2001,74,883: | 1 |
| 15 | Expression of pig endogenous retrovirus by primary porcine endothelial cells and infection of human cells显示文摘 | Martin U Kiessig V Blusch JH | 1998 | Lancet1998,352,: | 1 |
| 16 | Heterodimerization is required for the formation of a functional GABAB receptor显示文摘 | White JH Wise A Martin MJ Green A Fraser NJ Disney GH | 1998 | Nature1998,396,6712: | 1 |
| 17 | Hyperbaric oxygen therapy and cerebral ischemia:neuroprotective mechanisms显示文摘 | Matchett GA Martin RD Zhang JH | 2009 | Neurol Res2009,31,2: | 1 |
| 18 | Corticospinal system development depends on motor experience显示文摘 | Martin JH Choy M Pullman S | 2004 | J Neurosci2004,24,: | 1 |
| 19 | MR diffusion tensor imaging of white matter tract disruption in stroke at 3T显示文摘 | Gillard JH Papadakis NG Martin K | 2001 | Br J Radiol2001,74,: | 1 |
| 20 | The whiteflies(Hemiptera:Aleyrodidae) of Europe and the Mediterranean basin 显示文摘 | Martin JH Mifsud D Rapisarda C | 2000 | Bulletin of Entomological Research2000,90,: | 1 |