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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | 皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。 | Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 | 2016 | 国际脑血管病杂志2016，24，6： | 18 |
| 3 | NKX2-3 and IRGM variants are associated with diseasesu sceptibility to IBD in Eastern European patients显示文摘AIM: To investigate variants of immunity-related GT-Pase family M (IRGM) and NKX2-3 genes and genotype-phenotype in Eastern European patients with inflammatory bowel disease (IBD).METHODS: We analyzed 1707 Hungarian and Czech subjects with Crohn’s disease (CD) (n = 810, age: 37.1 ± 12.6 years, duration: 10.7 ± 8.4 years) and ulcerative colitis (UC) (n = 428, age: 43.7 ± 15.0 years, duration: 12.6 ± 9.9 years), as well as 469 healthy controls. IRGM rs13361189, NKX2-3 rs10883365 and ECM1 rs13294 polymorphisms were tested by LightCy-cler allele discrimination. Detailed clinical phenotypes were determined by reviewing the medical charts. RESULTS: NKX2-3 rs10883365 variant allele was as-sociated with increased risk for CD (P = 0.009, OR = 1.24, 95% CI = 1.06-1.48) and UC (P = 0.001, OR = 1.36, 95% CI = 1.13-1.63), whereas variant IRGM allele increased risk for CD (P = 0.029, OR = 1.36, 95% CI = 1.03-1.79). In contrast, ECM1 rs13294 was not associat-ed with either CD or UC. In CD, the variant IRGM allele was associated with a colon-only location (P = 0.02, OR = 1.62, 95% CI = 1.07-2.44), whereas in UC, the ECM1 variant was associated with cutaneous manifestations (P = 0.002, OR = 3.36, 95% CI = 1.48-7.63). Variant alleles did not predict resistance to steroids or azathio-prine, efficacy of infliximab, or need for surgery. CONCLUSION: NKX2-3 and IRGM are susceptibility locifor IBD in Eastern European patients. Further studies are needed to confirm the reported phenotype-genotype associations. | Nora Meggyesi Lajos S Kiss Magdalena Koszarska Martin Bortlik Dana Duricova Laszlo Lakatos Tamas Molnar Martin Lenicek Libor Vítek Istvan Altorjay Maria Papp Zsolt Tulassay Pal Miheller Janos Papp Attila Tordai Hajnalka Andrikovics Milan Lukas Peter Laszlo Lakatos | 2010 | World Journal of Gastroenterology2010，16，41： | 2 |
| 4 | Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli 显示文摘 | LENNON S V MARTIN S J COTTER T G | 1991 | Cell Prolif1991，24，2： | 1 |
| 5 | Engineering a mevalonate pathway in Escherichia coli for production of terpenoids显示文摘 | Martin V J J Pitera D J Withers S T | 2003 | Natur Biotechnology2003，21，7： | 1 |
| 6 | Reverse engineering of geometric models—an introduction显示文摘 | Tamás Várady Ralph R Martin Jordan Cox | 1997 | Computer-Aided Design1997，，4： | 1 |
| 7 | Optimization of Multistage Turbine Using a Through - Flow Code显示文摘 | Petrovie M V Dulikravieh G S and Martin T J | 2000 | ASME Paper 2000 - GT - 5212000，，： | 1 |
| 8 | Reduction of Protease Activity in Simulated Milk Ultra filtrate by Continuous Flow High Intensity Pulsed Electric Field Treatments 显示文摘 | S BENDICHO G V BARBOSA- CANOVAS O MARTIN | 2003 | Journal of Food Science2003，68，3： | 1 |
| 9 | Characterization of an unusual amylase gene from the bacterial predator Bdellovibrio bacteriovorus显示文摘 | Martin M O Studer S V Baren D M | 2003 | American Society for Microbiology2003，103，： | 1 |
| 10 | 2,3-butanediol production from xylose and other hemicellulosic components by Bacillus polymyxa显示文摘 | Laube V M Groleau D Martin S M | 1984 | Biotechnol Lett1984，6，4： | 1 |
| 11 | Adapive wavelet thresholding for image denoising and compression显示文摘 | Chang S G Yu B Martin V | 2000 | IEEE Transactions on Image Processing2000，9，9： | 1 |
| 12 | Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘 | Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R | 2009 | Journal of Bacteriology2009，191，16： | 1 |
| 13 | Optimal de- sign in vibration control of adaptive structures using a simula- ted annealing algorithm显示文摘 | Moita J M S Correia V M F Martins P G | 2006 | Composite Structures2006，75，1： | 1 |
| 14 | Severe alterations in lipid composition of Frontal Cortex lipid rafts from parkinson's disease and incidental parkinson's disease显示文摘 | Fabelo N Martin V Gabriel S | 2011 | Mol Med2011，17，910： | 1 |
| 15 | Characterization ofN-trimethyl chitosardalginate complexes andcurcumin release显示文摘 | Martins Alessandro F Bueno Pedro V A Almeida Elizangela A M S | 2013 | International Journal of Biological Macromolecules2013，57，： | 1 |
| 16 | The ability of slags to ab- sorb solid oxide inclusion显示文摘 | Martin V George S S Seetharaman S | 2006 | ISIJ Int2006，46，3： | 1 |
| 17 | Acute respiratory distress syndrome in non-trauma surgical patients:a 6-year study显示文摘 | Towfigh S Peralta M V Martin M J | 2009 | J Trauma2009，67，： | 1 |
| 18 | Fatigue behavior of the equine third metacarpus: mechanical property analysis 显示文摘 | Gibson V A Stover S M Martin R B | 1995 | J Orthop Res1995，13，6： | 1 |
| 19 | IL-1 and 1FN- gamma increase vascular permeability显示文摘 | Martin S Maruta K Burkart V | 1988 | Immunology1988，64，2： | 1 |
| 20 | Genetic parameters of health disorders,and relationships with 305-day milk yield and conformation traits of registered Holstein cows显示文摘 | Van Dorp R T E Dekkers J V M Martin S W | 1998 | Journal of Dairy Science1998，81，： | 1 |
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