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| 1 | Impaired norepinephrine regulation of monocyte inflammatory cytokine balance in heart failure显示文摘AIM To evaluate the effect of norepinephrine on inflammatory cytokine expression in ex vivo human monocytes and monocytic THP-1 cells. METHODS For human monocyte studies, cells were isolated from 12 chronic heart failure(HF)(66 ± 12 years, New York Heart Association functional class Ⅲ-Ⅳ, left ventricular ejection fraction 22% ± 9%) and 14 healthy subjects(66 ± 12 years). Monocytes(1 × 106/mL) were incubated with lipopolysaccharide(LPS) 100 ng/m L, LPS + norepinephrine(NE) 10-6 mol/L or neither(control) for 4 h. Tumor necrosis factor-alpha(TNFα) and interleukin-10(IL-10) production were determined by ELISA. Relative contribution of α- and β-adrenergic receptor subtypes on immunomodulatory activity of NE was assessed in LPSstimulated THP-1 cells incubated with NE, the α-selective agonist phenylephrine(PE), and the β-selective agonist isoproterenol(IPN). NE-pretreated THP-1 cells were also co-incubated with the β-selective antagonist propranolol(PROP), α2-selective antagonist yohimbine(YOH) or the α1-selective antagonist prazosin(PRAZ). RESULTS Basal TNFα concentrations were higher in HF vs healthy subjects(6.3 ± 3.3 pg/mL vs 2.5 ± 2.6 pg/mL, P = 0.004). Norepinephrine's effect on TNFα production was reduced in HF(-41% ± 17% HF vs -57% ± 9% healthy, P = 0.01), and proportionately with NYHA FC. Increases in IL-10 production by NE was also attenuated in HF(16% ± 18% HF vs 38% ± 23% healthy, P = 0.012). In THP-1 cells, NE and IPN, but not PE, induced a dosedependent suppression of TNFα. Co-incubation with NE and antagonists revealed a dose-dependent inhibition of the NE suppression of TNFα by PROP, but not by YOH or PRAZ. Dose-dependent increases in IL-10 production were seen with NE and IPN, but not with PE. This effect was also antagonized by PROP but not by YOH or PRAZ. Pretreatment of cells with IPN attenuated the effects of NE and IPN, but did not induce a response to PE.CONCLUSION NE regulation of monocyte inflammatory cytokine production may be reduced in moderate-severe HF, and may be mediated through β-adrenergic receptors. | Tien MH Ng Myron L Toews | 2016 | World Journal of Cardiology2016，8，10： | 4 |
| 2 | In vitro hypoxic preconditioning of embryonic stem cells as a strategy of promoting cell survival and functional benefits after transplantation into the ischemic rat brain 显示文摘 | Theus MH Wei L Cni L | 2008 | Exp Neurol2008，210，2： | 1 |
| 3 | Brugada-type electrocardiographic pattern induced by cocain 显示文摘 | Littmann L Monroe MH Svenson RH | 2000 | Mayo Clin Proc2000，75，8： | 1 |
| 4 | Review of clinical studies on dendritic cell-based vaccination of patients with malignant melanoma: assessment of correlation between clinical response and vaccine parameters 显示文摘 | Engell-Noerregaard L Hansen TH Andersen MH | 2009 | Cancer Immunol Immunother2009，58，1： | 1 |
| 5 | Acute phase proteins in the monitoring of inflammatory disorders显示文摘 | Van L MA Van Rj MH | 2004 | Bailliere''S Clia Rheumatol2004，8，： | 1 |
| 6 | Flow cytometry analysis of gingival and periodontal ligament cells显示文摘 | Kuru L Parkar MH Griffiths GS | 1998 | J Dent Res1998，77，4： | 1 |
| 7 | Association of the Metabolic Syndrome with History of Myocardial Infarction and Stroke in the Third National Health and Nurtrition Examination Survey显示文摘 | NINOMIYA JK L'ITALIEN G CRIQUI MH | 2004 | Circulation(S0009-7322)2004，109，： | 1 |
| 8 | Refinement of a rodent model of peripheral lymphedema显示文摘 | Lee-donaldson L Witte MH Bemas M | 1999 | Lymphology1999，32，： | 1 |
| 9 | Primary total hipreplacement : a comparison of a nationally agreed guide to bestpractice and current sur- gical technique determined by the NorthWest Regional Arthroplasty Register显示文摘 | Malik MH Gambhir AK Bale L | 2004 | Ann R Coil Surg Engl2004，86，2： | 1 |
| 10 | Verrucous hemangioma of the glans penis显示文摘 | Akyol L Jayanthi VR Luquette MH | | 0，，01： | 1 |
| 11 | Polyarteritis nodosa and Churg-Strauss angiitis: characteristics and outcome in 38 patients over 65 years 显示文摘 | Mouthon L Le Toumelin P Andre MH | 2002 | Medicine ( Baltimore )2002，81，1： | 1 |
| 12 | Incidence of pressure nlcers due to surgery 显示文摘 | Schoonhoven L Ddfloor T Gryrpdonck MH | 2002 | J Clin Nuts2002，11，4： | 1 |
| 13 | Detection of asymmetric giaucomatous damage using automated pupillography, the swinging flashlight method and the magnified-assisted swinging flashlight method 显示文摘 | WAISBOURD M LEE B ALI MH LU L MARTINEZ P FARIA B | 2015 | Eye (Lond)2015，29，10： | 1 |
| 14 | Acute renal haemodynamic effects of glucagon-like peptide-1 receptor agonist exenatide in healthy overweight men显示文摘 | Muskiet MH Tonneijck L Smits MM | 2016 | Diabetes Obes Metab2016，18，2： | 1 |
| 15 | Diagnostic value of dominant T-cell clones in peripheral blood in 363 patients presenting consecutively with a clinical suspicion of cutaneous lymphoma显示文摘 | Delfau-Larue MH Laroche L Wechsler J | 2000 | Blood2000，96，9： | 1 |
| 16 | C5a, interleukin-8 and tumour necrosis factor-alpha-induced changes in granulocyte and monocyte expression of complement receptors in whole blood and on isolated leukocytes 显示文摘 | Furebring MH Kansson L Venge P | 2006 | Scand J Immunol2006，63，3： | 1 |
| 17 | Dose-response of vasopressin in a rat model of asphyxial cardiac arrest显示文摘 | Chen MH Song FQ Xie L | 2009 | Am J Emerg Med2009，27，8： | 1 |
| 18 | Expression of growth-factor receptors in normal and regenerating human periodontal cells 显示文摘 | Parkar MH Kuru L Giouzeli M | 2001 | Arch Oral Biol2001，46，3： | 1 |
| 19 | Adult Wilms tumor: a report of prolonged survival and review of literature显示文摘 | Kilton L Matthews MJ Cohen MH | 1980 | J Urol1980，124，1： | 1 |
| 20 | Low dose octretide and tamoxifen in the treatment of the pancreas显示文摘 | Rosenberg L Barkun An Denis MH | 1995 | Cancer1995，75，： | 1 |
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