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| 1 | Role of vitamins in gastrointestinal diseases显示文摘A tremendous amount of data from research was published over the past decades concerning the roles of different vitamins in various gastrointestinal diseases.For instance,most vitamins showed an inverse relationship with the risk of colorectal carcinoma as well as other malignancies like gastric and esophageal cancer in observational trials,however interventional trials failed to prove a clear beneficial preventive role.On the other hand,more solid evidence was obtained from high quality studies for a role of certain vitamins in specific entities.Examples for this include the therapeutic role of vitamin E in patients with nonalcoholic steatohepatitis,the additive role of vitamins B12 and D to the standard therapy of chronic hepatitis C virus,the role of vitamin C in reducing the risk of gallstones,the positive outcome with vitamin B12 in patients with aphthous stomatitis,and the beneficial effect of vitamin D and B1 in patients with inflammatory bowel disease.Other potential uses are yet to be elaborated,like those on celiac disease,pancreatic cancer,pancreatitis,cholestasis and other potential fields.Data from several ongoing interventional trials are expected to add to the current knowledge over the coming few years.Given that vitamin supplementation is psychologically accepted by patients as a natural compound with relative safety and low cost,their use should be encouraged in the fields where positive data are available. | Omar A Masri Jean M Chalhoub Ala I Sharara | 2015 | World Journal of Gastroenterology2015，21，17： | 8 |
| 2 | Agmatine induces gastric protection against ischemic injury by reducing vascular permeability in rats显示文摘AIM:To investigate the effect of administration of agmatine(AGM) on gastric protection against ischemia reperfusion(I/R) injury.METHODS:Three groups of rats(6/group);sham,gastric I/R injury,and gastric I/R + AGM(100 mg/kg,i.p.given 15 min prior to gastric ischemia) were recruited.Gastric injury was conducted by ligating celiac artery for 30 min and reperfusion for another 30 min.Gastric tissues were histologically studied and immunostained with angiopoietin 1(Ang-1) and Ang-2.Vascular endothelial growth factor(VEGF) and monocyte chemoattractant protein-1(MCP-1) were measured in gastric tissue homogenate.To assess whether AKt/phosphatidyl inositol-3-kinase(PI3K) mediated the effect of AGM,an additional group was pretreated with Wortmannin(WM)(inhibitor of Akt/PI3K,15 μg/kg,i.p.),prior to ischemic injury and AGM treatment,and examined histologically and immunostained.Another set of experiments was run to study vascular permeability of the stomach using Evan's blue dye.RESULTS:AGM markedly reduced Evan's blue dye extravasation(3.58 ± 0.975 μg/stomach vs 1.175 ± 0.374 μg/stomach,P < 0.05),VEGF(36.87 ± 2.71 pg/100 mg protein vs 48.4 ± 6.53 pg/100 mg protein,P < 0.05) and MCP-1 tissue level(29.5 ± 7 pg/100 mg protein vs 41.17 ± 10.4 pg/100 mg protein,P < 0.01).It preserved gastric histology and reduced congestion.Ang-1 and Ang-2 immunostaining were reduced in stomach sections of AGM-treated animals.The administration of WM abolished the protective effects of AGM and extensive hemorrhage and ulcerations were seen.CONCLUSION:AGM protects the stomach against I/R injury by reducing vascular permeability and inflammation.This protection is possibly mediated by Akt/PI3K. | Abeer A Al Masri Eman El Eter | 2012 | World Journal of Gastroenterology2012，18，18： | 4 |
| 3 | Flow and mixing fields of turbulent bluff-body jets and flames显示文摘 | Dally B B Fletcher D F Masri A R | 1998 | Combust Theory Modeling1998，，2： | 2 |
| 4 | MUC1 affects c-Src signaling in PyV MT-induced mammary tumorigenesis显示文摘 | Al Masri A Gendler SJ | 2005 | Oncogene2005，24，38： | 1 |
| 5 | Relationship of high sensitivity C- reactive protein with presence and severity of coronary artery disease 显示文摘 | Habib S S Masri A | 2013 | Pak J Med Sci2013，29，6： | 1 |
| 6 | The effects of obstructions on overpressure resulting from premixed flame deflagration显示文摘 | Ibrahim S S Masri A R | 2001 | Journal of Loss Prevention in the Process Industries2001，14，3： | 1 |
| 7 | Hyponatraemia after acute spinal injury显示文摘 | Biyani A Inman CG el Masry WS | 1993 | Injury1993，24，10： | 1 |
| 8 | Modular tantalum augments for acetabular defects in revision hip arthroplasty显示文摘 | Siegmeth A Duncan CP Masri BA | | 0，，01： | 1 |
| 9 | Hyponatraemia after acute spinal injury显示文摘 | Biyani A Inman CG el Masry WS | 1993 | Injury1993，24，10： | 1 |
| 10 | Experimental study of premixed flame propagation over various solid obstructions显示文摘 | Masri A R Ibrahim S S Nehzat N | 2000 | Experimental Thermal and Fluid Science2000，21，13： | 1 |
| 11 | Conditioned place preference reveals tonic pain in an animal model of central pain显示文摘 | Davoody L Quiton R.L Lucas J.M Ji Y.D Keller A & Masri R | | 0，，： | 1 |
| 12 | Flow and mixing fields of turbulent bluff-body jets and flames显示文摘 | Dally B B Masri D F F A R | 1998 | Combustion Theory&Modelling1998，2，2： | 1 |
| 13 | The effects of obstructions on overpressure resulting from premixed flame deflagration 显示文摘 | Ibrahim S S Masri A R | 2001 | Journal of Loss Prevention in the Process Industries2001，14，： | 1 |
| 14 | Homing endonuclease I-CreI derivatives with novel DNA target specificities显示文摘 | ROSEN L E MORRISON H A MASRI S | 2006 | Nucleic AcidsResearch2006，34，17： | 1 |
| 15 | Bone marrow stromal cells stimulate neurite outgrowth over neural proteoglycans (CSPG),myelin associated glycoprotein and Nogo-A显示文摘 | Wright KT El Masri WE Osman A | | 0，，02： | 1 |
| 16 | Response of impact dampers with granular materials under random excitation 显示文摘 | Papalou A Masri S F | 1996 | Earquake Engineering and Structural Dynamics1996，25，： | 1 |
| 17 | Microarray delineation of familial chromosomal imbalance with deletion 5q35 and duplication 10q25 in a child showing multiple anomalies and dysmorphism显示文摘 | Masri A Gimelli S Hamamy H | 2014 | Am J Med Genet A2014，164，5： | 1 |
| 18 | Experimental study of premixed flame propagation over various solid obstructions 显示文摘 | Masri A R Ibrahim S S Nehzat N | 2000 | Experimental Thermal and Fluid Science2000，21，3： | 1 |
| 19 | Classification of Bone Loss in Total Hip Arthro Plasty显示文摘 | Masri B A Duncan C P | 1996 | J Instrcourse Lect1996，268，： | 1 |
| 20 | Response of impact dampers with granular materials under random excitation显示文摘 | Paplou A Masri S F | 1996 | Earthquake Engineering and Structural Dynamics1996，25，： | 1 |
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