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| 1 | N-acetyl-L-cysteine combined with mesalamine in the treatment of ulcerative colitis: Randomized,placebo-controlled pilot study显示文摘AIM: To evaluate the effectiveness and safety of oral N-acetyl-L-cysteine (NAC) co-administration with mesalamine in ulcerative colitis (UC) patients. METHODS: Thirty seven patients with mild to moderate UC were randomized to receive a four-wk course of oral mesalamine (2.4 g/d) plus N-acetyl-L-cysteine (0.8 g/d) (group A) or mesalamine plus placebo (group B). Patients were monitored using the Modified Truelove-Witts Severity Index (MTWSI). The primary endpoint was clinical remission (MTWSI ≤ 2) at 4 wk. Secondary endpoints were clinical response (defined as a reduction from baseline in the MTWSI of ≥ 2 points) and drug safety. The serum TNF-α, interleukin-6, interleukin-8 and MCP-1 were evaluated at baseline and at 4 wk of treatment. RESULTS: Analysis per-protocol criteria showed clinical remission rates of 63% and 50% after 4 wk treatment with mesalamine plus N-acetyl-L-cysteine (group A) and mesalamine plus placebo (group B) respectively (OR = 1.71; 95% CI: 0.46 to 6.36; P = 0.19; NNT = 7.7). Analysis of variance (ANOVA) of data indicated a significant reduction of MTWSI in group A (P = 0.046) with respect to basal condition without significant changes in the group B (P = 0.735) during treatment. Clinical responses were 66% (group A) vs 44% (group B) after 4 wk of treatment (OR = 2.5; 95% CI: 0.64 to 9.65; P = 0.11; NNT = 4.5). Clinical improvement in group A correlated with a decrease of IL-8 and MCP-1. Rates of adverse events did not differ significantly between both groups. CONCLUSION: In group A (oral NAC combined with mesalamine) contrarily to group B (mesalamine alone), the clinical improvement correlates with a decrease of chemokines such as MCP-1 and IL-8. NAC addition not produced any side effects. | Luis G Guijarro Jose Mate Javier P Gisbert Jose Luis Perez-Calle Ignacio Marín-Jimenez Encarna Arriaza Tomás Olleros Mario Delgado Maria S Castillejo David Prieto-Merino Venancio Gonzalez Lara Amado Salvador Pea | 2008 | World Journal of Gastroenterology2008，14，18： | 2 |
| 2 | A study of liquid metal atomization us- ing close-coupled nozzles, part 2: atomization behavior显示文摘 | Mates S P Settles G S | 2005 | At- omization and Sprays2005，15，1： | 1 |
| 3 | A study of liquid metal atomization using close-coupled nozzles, part 1: Gas dynamic behavior 显示文摘 | MATES S P SETTLES G S | 2005 | Atomization and Sprays2005，15，： | 1 |
| 4 | A study of liquid metal atomization using close-coupled nozzles, part 2: Atomization behavior 显示文摘 | MATES S P SETTLES G S | 2005 | Atomization and Sprays2005，15，： | 1 |
| 5 | Aromic-scale friction of a tungsten tip on a graphite surface 显示文摘 | C M Mate G M McClelland R Erlandsson and S Chiang | 1942 | Physic Rev Lett1942，59，17： | 1 |
| 6 | Persistence of spiromesifen in soil:influence of moisture,light,p H and organic amendment显示文摘 | MATE C J MUKHERJEE I DAS S K | 2015 | Environmental Monitoring&Assessment2015，187，2： | 1 |
| 7 | Nursing caries, linear hypoplasia, and nursing and weaning habits in Tanzanian infants显示文摘 | Matee M van't Hof M Maselle S el al | 1994 | Community Dent Oral Epidemiol1994，22，51： | 1 |
| 8 | Molecular evidence of sexual transmission of Ebola virus显示文摘 | Mate S Kugelman J Nyenshaw T | 2015 | N Engl J Med2015，373，25： | 1 |
| 9 | Prediction of axillary lymph node involvement of women with invasive breast carcinama: a multivariate analysis显示文摘 | Jackson J S Mates D | 1998 | cancer1998，83，5： | 1 |
| 10 | A first insight into the genetic diversity of Mycobacterium tuberculosisisolates in Dar es Salaam,Tanzaia,assessed by Spoligotyping显示文摘 | Eldholm V Matee M Mfinange S G | 2006 | BMC Microbiol2006，6，： | 1 |
| 11 | Desensitization to hydroxy-chloroquine-experience of 4 patients显示文摘 | Mates M Zevin S Breuer GS | 2006 | J Rheumatol2006，33，4： | 1 |
| 12 | Mem- brane potential and gentamicin uptake in Staphylococcus au- reus 显示文摘 | MATES S M E1SENBERG E S MANDEL L J | 1982 | Proceedings of the National Academy of Sciences of the United States of America1982，79，21： | 1 |
| 13 | A study of liquid metal atomization using close-coupled nozzles, Part 1: Gas dynamic behavior 显示文摘 | MATES S P SETTLES G S | 2005 | Atomization and Sprays2005，15，1： | 1 |
| 14 | Roles of dioxins and heavy metals in cancer and neurological diseases using ROS-mediated mechanisms显示文摘 | Mate's JM Segura JA Alonso FJ | 2010 | Free Radic Biol Med2010，49，9： | 1 |
| 15 | Hydrogenation of polycrystalline silicon thin films 显示文摘 | HONDA S MATES T KNIZEK K | 2006 | Thin Solid Films2006，501，12： | 1 |
| 16 | Atomic-scale friction of a tungsten tip on a graphite surface显示文摘 | Mate C M Mcclelland G M Erlandsson R Chiang S | 1987 | Physical Review Letters1987，59，17： | 1 |
| 17 | Glutathione and its relationship with intracellular redox status, oxidative stress and cell proliferation/death显示文摘 | MATE′S J M PE′REZ-GO′MEZ C NU′NˇEZ DE CASTRO I ASENJO M MA′RQUEZ J | 2002 | The International Journal of Biochemistry & Cell Biology2002，34，： | 1 |
| 18 | Mutans streptococci and lactobacilli in Breast-Fed children with rampant Caries显示文摘 | Matee M I Mikx F H Masellsym S Y M | 1992 | Caries Res1992，26，3： | 1 |
| 19 | Reprogramming of the circadian clock by nutritional challenge显示文摘 | Eckel-Mahan K L Patel V R de Matee S | 2013 | Cell2013，155，7： | 1 |
| 20 | Germline transgen- ic pigs by sleeping beauty transposition in porcine zy- gotes and targeted integration in the pig genome显示文摘 | Garrels W Mates L Holler S 2011 | 2011 | Plos One2011，6，23： | 1 |
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