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| 1 | Apoptosis and non-alcoholic fatty liver diseases显示文摘The number of patients with nonalcoholic fatty liver diseases(NAFLD) including nonalcoholic steatohepatitis(NASH), has been increasing. NASH causes cirrhosis and hepatocellular carcinoma(HCC) and is one of the most serious health problems in the world. The mechanism through which NASH progresses is still largely unknown. Activation of caspases, Bcl-2 family proteins, and c-Jun N-terminal kinase-induced hepatocyte apoptosis plays a role in the activation of NAFLD/NASH. Apoptotic hepatocytes stimulate immune cells and hepatic stellate cells toward the progression of fibrosis in the liver through the production of inflammasomes and cytokines. Abnormalities in glucose and lipid metabolism as well as microbiota accelerate these processes. The production of reactive oxygen species, oxidative stress, and endoplasmic reticulum stress is also involved. Cell death, including apoptosis, seems very important in the progression of NAFLD and NASH. Recently, inhibitors of apoptosis have been developed as drugs for the treatment of NASH and may prevent cirrhosis and HCC. Increased hepatocyte apoptosis may distinguish NASH from NAFLD, and the improvement of apoptosis could play a role in controlling the development of NASH. In this review, the association between apoptosis and NAFLD/NASH are discussed. This review could provide their knowledge, which plays a role in seeing the patients with NAFLD/NASH in daily clinical practice. | Tatsuo Kanda Shunichi Matsuoka Motomi Yamazaki Toshikatsu Shibata Kazushige Nirei Hiroshi Takahashi Tomohiro Kaneko Mariko Fujisawa Teruhisa Higuchi Hitomi Nakamura Naoki Matsumoto Hiroaki Yamagami Masahiro Ogawa Hiroo Imazu Kazumichi Kuroda Mitsuhiko Moriyama | 2018 | World Journal of Gastroenterology2018，24，25： | 32 |
| 2 | 全球气候变化对中国未来地表径流的影响显示文摘本文应用改进的水分平衡模型研究了不同气候变化情景下中国未来地表径流的变化。结果表明 :基于不同的气候变化情景模拟所得的地表径流变化在空间上有差异 ,总体上 ,中国未来的地表径流将增加 ;长江上游地区的地表径流春季下降但在夏季增加 ,而下游地区的则相反 ,夏季径流下降而春季径流剧增 ;气溶胶对地表径流变化方面有影响 ,但在各个气候变化情景下缺乏一致性。 | 游松财 Kiyoshi Takahashi Yuzuru Matsuoka | 2002 | 第四纪研究2002，22，2： | 29 |
| 3 | Rho/ROCK signaling in motility and metastasis of gastric cancer显示文摘Gastric cancer is one of the most frequent and lethal malignancies worldwide because of high frequency of metastasis. Tumor cell motility and invasion play fundamental roles in cancer metastasis. Recent studies have revealed that the Rho/Rho-associated protein kinases(ROCK) pathway plays a critical role in the regulation of cancer cell motility and invasion. In addition,the Rho/ROCK pathway plays important roles in invasion and metastasis on the basis of its predominant function of cell cytoskeletal regulation in gastric cancer. According to the current understanding of tumor motility,there are two modes of tumor cell movement:mesenchymal and amoeboid. In addition,cancer cell movement can be interchangeable between the mesenchymal and amoeboid movements under certain conditions. Control of cell motility through the actin cytoskeleton creates the potential for regulating tumor cell metastasis. In this review we discuss Rho GTPases and ROCK signaling and describe the mechanisms of Rho/ROCK activity with regard to motility and metastasis in gastric cancer.In addition,we provide an insight of the therapeutic potential of targeting the Rho/ROCK pathway. | Tasuku Matsuoka Masakazu Yashiro | 2014 | World Journal of Gastroenterology2014，20，38： | 27 |
| 4 | Improving recognition of hepatic perivascular epithelioid cell tumor:Case report and literature review显示文摘A 58-year-old man presented with the chief complaint of abdominal bloating and was incidentally found to have a liver tumor.As diagnostic imaging studies could not rule out malignancy,the patient underwent partial resection of segment 3 of the liver.The lesion pathologically showed eosinophilic proliferation,in addition to immunohistochemical positivity for human melanoma black 45 and Melan-A,thereby leading to the diagnosis of a hepatic perivascular epithelioid cell tumor(PEComa).A PEComa arising from the liver is relatively rare.Moreover,the name ‘PEComa' has not yet been widely recognized,and the same disease entity has been called epithelioid angiomyolipoma(EAML),further diminishing the recognition of PEComa.In addition,PEComa imaging findings mimic those of malignant liver tumors,and clinically,this tumor tends to enlarge.Therefore,a PEComa is difficult to diagnose.We conducted a systematic review of PEComa and EAML cases and discuss the results,including findings useful for differentiating perivascular epithelioid cell tumors from malignant liver tumors. | Toshiya Maebayashi Katsumi Abe Takuya Aizawa Masakuni Sakaguchi Naoya Ishibashi Osamu Abe Tadatoshi Takayama Hisashi Nakayama Shunichi Matsuoka Kazushige Nirei Hitomi Nakamura Masahiro Ogawa Masahiko Sugitani | 2015 | World Journal of Gastroenterology2015，21，17： | 20 |
| 5 | SMALL ORGAN SIZE 1 and SMALL ORGAN SIZE 2/DWARF AND LOW-TILLERING Form aComplex to Integrate Auxin and Brassinosteroid Signaling in Rice显示文摘尽管植物生长素和 brassinosteroid (BR ) synergistically 控制各种各样的植物回答,位于 auxin-BR 串音下面的分子的机制很好没被理解。我们以前识别了 SMOS1,一个调整植物生长素的 APETALA2 类型抄写因素,作为小机关的原因的基因缩放 1 (smos1 ) 被各种各样的机关的一种减少的最后的尺寸在米饭描绘的异种。在这研究,我们识别了另一 smos 异种, smos2,哪个表演与 smos1 难区分的显型。SMOS2 与以前报导的矮子和 LOW-TILLERING (DLT ) 相同,它编码涉及 BR 发信号的 GRAS 蛋白质。SMOS1 和 SMOS2/DLT 身体上交往合作地在酵母并且在米饭原子核提高 transcriptional transactivation 活动。一致地, OsPHI-1 的表示, SMOS1 的一个直接目标,当 SMOS1 和 SMOS2/DLT 蛋白质两个都是在米饭房间的现在时,仅仅是 upregulated。一起拿,我们的结果建议 SMOS1 和 SMOS2/DLT 在在米饭表明串音的 auxin-BR 上形成重点建筑群。 | Ko Hirano Hideki Yoshida Koichiro Aya Mayuko Kawamura Makoto Hayashi Tokunori Hobo Karma Sato-lzawa Hidemi Kitano Miyako Ueguchi-Tanaka Makoto Matsuoka | 2017 | Molecular Plant2017，10，4： | 20 |
| 6 | 有毒亚历山大藻(Alexandrium spp.)和链状裸甲藻(Gymnodinium catenatum)孢囊在中国沿海的分布显示文摘于 2 0 0 0— 2 0 0 1年采集了中国沿海 1 0个采样点的表层沉积物样品 ,研究了有毒亚历山大藻 (Alexandriumspp .)和链状裸甲藻 (Gymnodiniumcatenatum)孢囊的分布。结果表明 ,这两类孢囊几乎在所有采样点都检测到。链状裸甲藻孢囊虽分布广泛 ,但含量较低 ,在样品中的浓度和百分比含量分别为 0— 71 .1cysts/gDW和 0 %— 1 4.3%。亚历山大藻孢囊在大部分海域含量较低 ,而在PSP毒素中毒事件高发区和贝类PSP毒素高含量区的大亚湾大鹏澳海域却高密度、高频率地出现 ,最高密度为 366cysts/gDW。研究结果显示 ,大亚湾大鹏澳海域表层沉积物中高密度的亚历山大藻孢囊也许是该海域贝类体内冬季PSP毒素积累及高含量的重要原因之一。 | 王朝晖 MATSUOKA Kazumi 齐雨藻 吕颂辉 | 2003 | 海洋与湖沼2003，34，4： | 20 |
| 7 | 大亚湾澳头海域表层沉积物中甲藻孢囊的垂直分布显示文摘于2001年8月采集了大亚湾澳头海域3个采样点约20cm柱状沉积物样品,研究了甲藻孢囊的垂直分布。该海域孢囊种类较丰富,共分析鉴定出20个属的38种孢囊类型。孢囊数量十分高,3个站位上表层12cm沉积物中孢囊的平均数量分别为4 13、2 02、1 14×104/g,最高达1 12×105/g。锥状斯氏藻(Scrippsiellatrochoidea)孢囊是压倒性优势种类,在大部分样品中该孢囊的数量超过了50%,上表层甚至超过了90%。孢囊的H′为0 15~3 51,3个站位平均分别为0 78、1 66、2 72。结果显示大亚湾澳头海域在20世纪80年代开始就受到污染,90年代后污染加重,而近5a来则更加严重。 | 王朝晖 KAZUMI MATSUOKA 齐雨藻 辜小莲 | 2003 | 海洋环境科学2003，22，4： | 16 |
| 8 | Long-term outcome of percutaneous ethanol injection therapy for minimum-sized hepatocellular carcinoma显示文摘AIM: To evaluate long-term follow-up of minimum-sized hepatocellular carcinoma (HCC) treated with percutaneous ethanol injection (PEI). METHODS: PEI was applied to 42 lesions in 31 patients (23 male and eight female) with HCC < 15 mm in diameter, over the past 15 years. RESULTS: Overall survival rate was 74.1% at 3 years, 49.9% at 5 years, 27.2% at 7 years and 14.5% at 10 years. These results are superior to, or at least the same as those for hepatic resection and radiofrequency ablation. Survival was affected only by liver function, but not by sex, age, etiology of Hepatitis B virus or Hepatitis C virus, α-fetoprotein levels, arterial and portal blood flow, histological characteristics, and tumor multiplicity or size. Patients in Child-Pugh class A and B had 5-, 7- and 10-years survival rates of 76.0%, 42.2% and 15.8%, and 17.1%, 8.6% and 0%, respectively (P = 0.025). CONCLUSION: Treatment with PEI is best indicated for patients with HCC < 15 mm in Child-Pugh class A. | Miyuki Taniguchi Soo Ryang Kim Susumu Imoto Hirotsugu Ikawa Kenji Ando Keiji Mita Shuichi Fuki Noriko Sasase Toshiyuki Matsuoka Masatoshi Kudo Yoshitake Hayashi | 2008 | World Journal of Gastroenterology2008，14，13： | 16 |
| 9 | Sentinel node navigation surgery for gastric cancer: Overview and perspective显示文摘The sentinel node(SN) technique has been established for the treatment of some types of solid cancers to avoid unnecessary lymphadenectomy. If node disease were diagnosed before surgery, minimal surgery with omission of lymph node dissection would be an option for patients with early gastric cancer. Although SN biopsy has been well ascertained in the treatment of breast cancer and melanoma, SN navigation surgery(SNNS) in gastric cancer has not been yet universal due to the complicated lymphatic flow from the stomach. Satisfactory establishment of SNNS will result in the possible indication of minimally invasive surgery of gastric cancer. However, the results reported in the literature on SN biopsy in gastric cancer are widely divergent and many issues are still to be resolved, such as the collection method of SN, detection of micrometastasis in SN, and clinical benefit. The difference in the procedural technique and learning phase of surgeons is also varied the accuracy of SN mapping. In this review, we outline the current status of application for SNNS in gastric cancer. | Masakazu Yashiro Tasuku Matsuoka | 2015 | World Journal of Gastrointestinal Surgery2015，7，1： | 13 |
| 10 | Recent advances in the HER2 targeted therapy of gastric cancer显示文摘Recent advances in molecular targeted therapies, including targeting human epidermal growth factor receptor 2(HER2), had a major forward step in the therapy for gastric cancer patients. Application of HER2-targeted therapies, in particular trastuzumab in combination with chemotherapy in metastatic HER2-positive gastric cancers, resulted in improvements in response rates, time to progression and overall survival. Nevertheless, as with breast cancer, many patients with gastric cancer develop resistance to trastuzumab. Several promising therapies are currently being developed in combination with chemotherapy to increase the efficacy and overcome the cancerresistance. Here we review the current overview of clinical application of agents targeting HER2 in gastric cancer. We also discuss the ongoing trials supporting the use of HER2-targeted agents combined with cytotoxic agents or other monoclonal antibodies. | Tasuku Matsuoka Masakazu Yashiro | 2015 | World Journal of Clinical Cases2015，3，1： | 12 |
| 11 | Isolation of a Novel Lodging Resistance QTL Gene Involved in Strigolactone Signaling and Its Pyramiding with a QTL Gene Involved in Another Mechanism显示文摘住宿是到达到增加的庄稼生产率的一个主要障碍。在一次尝试到在米饭为灰煤杆力量理解机制,我们孤立一个有效量的特点地点( QTL ),强壮的 CULM3 ( SCM3 ),哪个与米饭 TEOSINTE BRANCHED1 ( OsTB1 )相同的原因的基因,基因以前报导了断然控制发信号的 strigolactone ( SL )。带 SCM3 的一根 near-isogenic 线(无) 证明尽管有期望的减少,提高的灰煤杆力量和增加的小穗状花小穗在 tiller 数字数,显示 SL 也有在提高灰煤杆力量和小穗状花小穗数字的一个积极角色。我们生产了带 SCM3 和 SCM2 的一根节节上升的线,编码涉及圆锥花序开发的 APO1 的另一 QTL。NIL-SCM2+SCM3 比 NIL-SCM2 和 NIL-SCM3 和这些 QTL 的添加剂效果引起的一个增加的小穗状花小穗数字显示出强壮得多的灰煤杆。我们讨论没有为繁殖导致有害特点,利用这些强壮的灰煤杆 QTL 的合适的等位基因的重要性。 | Kenji Yano Taiichiro Ookawa Koichiro Aya Yusuke Ochiai Tadashi Hirasawa Takeshi Ebitani Takeshi Takarada Masahiro Yano Toshio Yamamoto Shuichi Fukuoka Jianzhong Wu Tsuyu Ando Reynante Lacsamana Ordonio Ko Hirano Makoto Matsuoka | 2015 | Molecular Plant2015，8，2： | 12 |
| 12 | 深圳湾表层沉积物中甲藻孢囊的垂直分布显示文摘集了深圳湾 3个采样点约 2 0 cm的表层沉积物样品 ,研究了甲藻孢囊的垂直分布。共分析鉴定出孢囊类型 37种 ,其中 5种为我国沿海未报道的新记录类型 ,原多甲藻类孢囊是该海域种类最丰富的孢囊类型。除上表层沉积物外 ,深圳湾甲藻孢囊密度较低 ,孢囊密度大多在 50 0 cysts/ g D Wt以下 ,总孢囊密度变化范围为 83~ 40 36 cysts/ g D Wt之间。锥状斯氏藻是深圳湾甲藻孢囊的优势种类 ,上表层沉积物中该孢囊密度的急剧上升证实了 2 0 0 0年附近海域所发生的该藻赤潮。而裸甲藻类孢囊含量明显比南海其他海域高。孢囊的香农 -威弗种类多样性指数为 1 .50~ 3.96之间 ,并且在非养殖区、离岸海域及较深层次沉积物中较高 ,而孢囊密度则呈相反的变化趋势。种类多样性的下降及孢囊密度的上升在一定程度上说明深圳湾污染的变化趋势 ,富营养化程度非养殖区大于养殖区 ,近岸海域大于离岸海域 。 | 王朝晖 Kazumi Matsuoka 齐雨藻 辜小莲 | 2003 | 生态学报2003，23，10： | 10 |
| 13 | Down-regulation of pancreatic transcription factors and incretin receptors in type 2 diabetes显示文摘Type 2 diabetes is one of the most prevalent and serious metabolic diseases.Under diabetic conditions,chronic hyperglycemia and subsequent induction of oxidative stress deteriorate pancreaticβ-cell function,which leads to the aggravation of type 2 diabetes.Although such phenomena are well known as glucose toxicity,its molecular mechanism remains unclear.In this review article,we describe the possible molecular mechanism forβ-cell dysfunction found in type 2 diabetes,focusing on(1)oxidative stress,(2)pancreatic transcription factors(PDX-1 and MafA)and(3)incretin receptors(GLP-1 and GIP receptors).Under such conditions,nuclear expression levels of PDX-1 and MafA are decreased,which leads to suppression of insulin biosynthesis and secretion.In addition,expression levels of GLP-1 and GIP receptors are decreased,which likely contributes to the impaired incretin effects found in diabetes.Taken together,it is likely that downregulation of pancreatic transcription factors(PDX-1and MafA)and down-regulation of incretin receptors(GLP-1 and GIP receptors)explain,at least in part,the molecular mechanism forβ-cell dysfunction found in type 2 diabetes. | Hideaki Kaneto Taka-aki Matsuoka | 2013 | World Journal of Diabetes2013，4，6： | 9 |
| 14 | Fibroblast growth factor receptor signaling as therapeutic targets in gastric cancer显示文摘Fibroblast growth factor receptors(FGFRs) regulate a variety of cellular functions, from embryogenesis to adult tissue homeostasis. FGFR signaling also plays significant roles in the proliferation, invasion, and survival of several types of tumor cells. FGFR-induced alterations, including gene amplification, chromosomal translocation, and mutations, have been shown to be associated with the tumor initiation and progression of gastric cancer, especially in diffuse-type cancers. Therefore, the FGFR signaling pathway might be one of the therapeutic targets in gastric cancer. This review aims to provide an overview of the role of FGFR signaling in tumorigenesis, tumor progression, proliferation, and chemoresistance. We also discuss the accumulating evidence that demonstrates the effectiveness of using clinical therapeutic agents to inhibit FGFR signaling for the treatment of gastric cancer. | Masakazu Yashiro Tasuku Matsuoka | 2016 | World Journal of Gastroenterology2016，22，8： | 8 |
| 15 | Progress in researches about focal adhesion kinase in gastrointestinal tract显示文摘Focal adhesion kinase(FAK)is a 125-kDa non-receptor protein tyrosine.Growth factors or the clustering of integrins facilitate the rapid phosphorylation of FAK at Tyr-397 and this in turn recruits Src-family protein tyrosine kinases,resulting in the phosphorylation of Tyr-576 and Tyr-577 in the FAK activation loop and full catalytic FAK activation.FAK plays a critical role in the biological processes of normal and cancer cells including the gastrointestinal tract.FAK also plays an important role in the restitution,cell survival and apoptosis and carcinogenesis of the gastrointestinal tract.FAK is over-expressed in cancer cells and its over-expression and elevated activities are associated with motility and invasion of cancer cells.FAK has been proposed as a potential target in cancer therapy.Small molecule inhibitors effectively inhibit the kinase activity of FAK and show a potent inhibitory effect for the proliferation and migration of tumor cells,indicating a high potential for application in cancer therapy. | Hui Fang Hao Yoshio Naomoto Xiao-Hong Bao Nobuyuki Watanabe Kazufumi Sakurama Kazuhiro Noma Yasuko Tomono Takuya Fukazawa Yasuhiro Shirakawa Tomoki Yamatsuji Junji Matsuoka Munenori Takaoka | 2009 | World Journal of Gastroenterology2009，15，47： | 8 |
| 16 | 柘林湾近代沉积物中甲藻孢囊的垂直分布显示文摘于 2001 年 月在柘林湾 个采样点采集了各约 4 3 20 cm的沉积物柱状样,分层研究了甲藻孢囊的垂直分布。在 个沉积物样品中共分析鉴定出甲藻孢囊47 种,而且还观察到了 种该海域特有的种类。 33 3孢囊组成以原多甲藻等异养型孢囊为主,而有毒的亚历山大藻和链状裸甲藻孢囊也均有分布。每个样品中所分析鉴定的孢囊种类数较少,仅有 ~ 种,平均 种。孢囊丰度也较低,在 ~ 5 16 10 59 1 998 cysts/g D Wt之间,平均 280 cysts/g D Wt。香农-威弗种类多样性指数和孢囊种类数都以位于非养殖区湾外海域的 S3站最高,同时在3 个站位的6~8 cm 层次处,随深度的增加均有较大幅度的上升。研究结果表明,柘林湾的富营养化程度较高,而且湾内海域大于湾外海域,养殖区大于非养殖区,近年有加剧的趋势。 | 王朝晖 Kazumi Matsuoka 齐雨藻 辜小莲 | 2004 | 海洋通报2004，23，3： | 7 |
| 17 | Diagnostic sensitivity of imaging modalities for hepatocellular carcinoma smaller than 2 cm显示文摘AIM:To compare the imaging results with histology and to evaluate the diagnostic sensitivity of imaging modalities for hepatocellular carcinoma(HCC)smaller than 2 cm.METHODS:Nodules smaller than 2 cm(n=34)revealed by ultrasonography(US)in 29 patients with liver cirrhosis were analyzed.Histological diagnosis of HCC was performed by ultrasonographic guidance:moderately-differentiated HCC(n=24);well-differentiated HCC(n=10).The patterns disclosed by the four imaging modalities defined the conclusive diagnosis of HCC:(1)contrast-enhanced computed tomography(CECT),hypervascularity in the arterial phase and washout in the equilibrium phase;(2)Sonazoid contrast-enhanced US(CEUS),hypervascularity in the early vascular phase and defect in the Kupffer phase;(3)gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid(Gd-EOBDTPA)-enhanced magnetic resonance imaging(MRI),hypervascularity in the arterial phase and/or defect in the hepatobiliary phase;and(4)CT arterioportal angiography:hypervascularity by CT during arteriography and/ or perfusion defect by CT during arterial portography.RESULTS:Overall,the sensitivity of diagnosing HCC smaller than 2 cm was 52.9%(18/34)(95%CI:35.170.2)by CECT;67.6%(23/34)(95%CI:49.5-82.6)by Sonazoid CEUS;76.5%(26/34)(95%CI:58.8-89.3) by Gd-EOB-DTPA MRI;and 88.2%(30/34)(95%CI: 72.5-96.7)by CT arterioportal angiography.The diagnostic sensitivity of detecting moderately-differentiated HCC by CECT,Sonazoid CEUS,Gd-EOB-DTPA MRI and CT arterioportal angiography was 62.5%(15/24)(95%CI: 40.6-81.2),79.2%(19/24)(95%CI:57.8-92.9),75.0% (18/24)(95%CI:53.3-90.2)and 95.8%(23/24)(95% CI:78.9-99.9),respectively.A significant difference(P< 0.05)was observed between CECT and CT arterioportal angiography in all nodules.There was no difference between Sonazoid CEUS,Gd-EOB-DTPA MRI,and CT arterioportal angiography.The combined sensitivity of Sonazoid CEUS and Gd-EOB-DTPA MRI was 94.1%(32/34).CONCLUSION:Changing the main diagnostic modality for HCC smaller than 2 cm from CT arterioportal angiography to Sonazoid CEUS and Gd-EOB-DTPA MRI is recommended. | Keiji Mita Soo Ryang Kim Masatoshi Kudo Susumu Imoto Taisuke Nakajima Kenji Ando Katsumi Fukuda Toshiyuki Matsuoka Yoko Maekawa Yoshitake Hayashi | 2010 | World Journal of Gastroenterology2010，16，33： | 7 |
| 18 | 主动脉夹层破裂出血沿肺动脉延伸的CT及临床表现显示文摘本研究的目的是评价主动脉夹层(AD)破裂出血沿肺动脉(PA)延伸的CT表现及其预后因素。在232例Stanford A型主动脉夹层病人中,诊断出21例(9.1%;女性11例;平均70-3岁)。12例病人具有双腔(经典型),9例病人有主动脉壁内血肿(IMH;闭合的假腔)。基于CT表现,出血可以分为3类:第1类,肺动脉IMH或环绕肺动脉的出血;第2类,出血延伸至小叶间隔;第3类,出血延伸至肺泡内。影响预后的因素包括CT表现和病人的临床特征。21例中有14例(66.7%)进行了急诊手术, | E. Sueyoshi Y. Matsuoka I. Sakamoto M. Uetani 马延贺(译) 李威(校) | 2009 | 国际医学放射学杂志2009，32，4： | 7 |
| 19 | A low-voltage low-power CMOS voltage reference based on subthreshold MOSFETs显示文摘This paper describes a CMOS voltage reference using only resistors and transistors working in weak inversion,without the need for any bipolar transistors.The voltage reference is designed and fabricated by a 0.18μm CMOS process.The experimental results show that the proposed voltage reference has a temperature coefficient of 370 ppm/℃at a 0.8 V supply voltage over the temperature range of-35 to 85℃and a 0.1%variation in supply voltage from 0.8 to 3 V.Furthermore,the supply current is only 1.5μA at 0.8 V supply voltage. | 王洪来 张小兴 戴宇杰 吕英杰 Toshimasa Matsuoka Wang Jun Kenji Taniguchi | 2011 | Journal of Semiconductors2011，32，8： | 5 |
| 20 | Precision medicine for gastrointestinal cancer:Recent progress and future perspective显示文摘Gastrointestinal(GI)cancer has a high tumor incidence and mortality rate worldwide.Despite significant improvements in radiotherapy,chemotherapy,and targeted therapy for GI cancer over the last decade,GI cancer is characterized by high recurrence rates and a dismal prognosis.There is an urgent need for new diagnostic and therapeutic approaches.Recent technological advances and the accumulation of clinical data are moving toward the use of precision medicine in GI cancer.Here we review the application and status of precision medicine in GI cancer.Analyses of liquid biopsy specimens provide comprehensive real-time data of the tumor-associated changes in an individual GI cancer patient with malignancy.With the introduction of gene panels including next-generation sequencing,it has become possible to identify a variety of mutations and genetic biomarkers in GI cancer.Although the genomic aberration of GI cancer is apparently less actionable compared to other solid tumors,novel informative analyses derived from comprehensive gene profiling may lead to the discovery of precise molecular targeted drugs.These progressions will make it feasible to incorporate clinical,genome-based,and phenotype-based diagnostic and therapeutic approaches and apply them to individual GI cancer patients for precision medicine. | Tasuku Matsuoka Masakazu Yashiro | 2020 | World Journal of Gastrointestinal Oncology2020，12，1： | 5 |
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