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| 1 | Therapeutic options for HER-2 positive breast cancer: Perspectives and future directions显示文摘During the last 15 years we have witnessed an unprecedented expansion in the drugs developed to target human epidermal growth factor receptor-2(HER-2) positive breast cancer. Trastuzumab, pertuzumab, adotrastuzumab emtansine and lapatinib are currently food and drug administration(FDA)-approved for the treatment of breast cancer patients with HER-2 overexpressed. However, given the amount of information gathered from years of uninterrupted clinical research, it is essential to have periodic updates that succinctly recapitulate what we have learnt over these last years and help us to apply that information in our daily practice. This review will pursue that objective. We will summarize the most relevant and updated informationrelated to the state of the art management of HER-2 positive breast cancer in all the clinical scenarios including the adjuvant, neoadjuvant and metastatic settings. But we will also critically appraise that literature in order to highlight some key clinical concepts that should not be overlooked. Lastly, this review will also point out some of the most promising strategies that are currently being tested and may soon become available. | Gonzalo Recondo Jr Enrique Dìaz Canton Màximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Clinical Oncology2014，5，3： | 7 |
| 2 | Advances and new perspectives in the treatment of metastatic colon cancer显示文摘During the last decade we have witnessed an unprec-edented outburst of new treatment approaches for the management of metastatic colon cancer.Anti-angio-genic drugs,epidermal growth factor receptor blockers and multi-kinase inhibitors have all resulted in small but consistent improvement in clinical outcomes.However,this progress has paradoxically leaded us into new chal-lenges.In many cases the clinical development was done in parallel and the lack of head-to-head compari-son evolved into circumstances where several valid new'standards of care'are available.Even though desir-able in essence,the availability of many options as well as different possible combinations frequently leaves the busy clinician in the difficult situation of having to choose between one or the other,sometimes without solid evidence to support each decision.In addition,progress never stops and new agents are continuously tested.For these reason this review will try to summa-rize all the clinical trials that constitute the theoretical framework that support our daily practice but will also procure the reader with rational answers to common clinical dilemmas by critically appraising the current literature.Lastly,we will provide with a compilation of promising new agents that may soon become our next line of defense against this deadly disease. | Gonzalo Recondo Jr Enrique Díaz-Cantón Máximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi | 2014 | World Journal of Gastrointestinal Oncology2014，6，7： | 2 |
| 3 | Wavelet-based histograms for selectivity estimation 显示文摘 | Matias Y Vitter J S Wang M | 1998 | ACM SIGMOD Record1998，27，2： | 1 |
| 4 | Energy scenarios:Toward a new energy paradigm显示文摘 | DEVEZAS TESSALENO LEPOIRE DAVID MATIAS JOAO C O SILVAABILIO M P | 2008 | Futures2008，40，1： | 1 |
| 5 | Nonadiabatic tapered single-mode fiber coated with humidity sensitive nanofilms 显示文摘 | J M Corres J Bravo I R Matias | 2006 | IEEETechnol Lett2006，18，8： | 1 |
| 6 | Paratestieular sarcomas: two cases with different evolutions 显示文摘 | Matias M Carvalho M Xavier L | 2014 | BMJ Case Reports2014，，： | 1 |
| 7 | Design of humidity sensors based on tapered optical fibers 显示文摘 | CORRES J M ARREGUI F J MATIAS I R | 2006 | J Lightwave Technology2006，24，11： | 1 |
| 8 | Expression of tolerance for Meloidogyne graminicola in rice euhivars as affected by soil type and flooding显示文摘 | Soriano I R S Prot J C Matias D M | 2000 | Journal of nematology2000，，32： | 1 |
| 9 | Control of chaos in unidimensional maps 显示文摘 | GUEMEZ J MATIAS M A | 1993 | Phys Lett1993，182，： | 1 |
| 10 | Stabilization of chaos by proportional pulses in the system variables显示文摘 | MATIAS M A GUEMEZ J | 1994 | Phys Lett1994，72，10： | 1 |
| 11 | Two members of the thioredoxin-h family interact with the kinase domain of a Brassica S-locus receptor kinase 显示文摘 | Bower M S Matias D D Femandes-carvalho E Mazzurco M Gu T Rothstein A J and Goring D R | 1996 | Plant Cell1996，8，： | 1 |
| 12 | Stablization of chaos by proportional pulses in the system variables显示文摘 | MATIAS M A GUEMEZ J | 1994 | Phys Rev Lett1994，72，： | 1 |
| 13 | The fuzzy Kalman filter:State estimation using possibilistic techniques显示文摘 | Matia Fernando Jimenez Agustin Al-Hadithi Basil M | 2006 | Fuzzy sets and systems2006，157，16： | 1 |
| 14 | Chaotic synchronization in small assemblies of driven Chua's circuits显示文摘 | Matias M Munuzuri V | 2000 | IEEE Trans Circuits and Syst Ⅰ2000，47，5： | 1 |
| 15 | Effectsof commercial microbial products on water quality in tropi-cal shrimp culture ponds显示文摘 | MATIAS H B YUSOFF F M SHARIFF M | 2002 | Asian Fisheries Science2002，15，： | 1 |
| 16 | Sensitivity optimization of tapered optical fiber humidity sensors by means of tuning the thickness of nanostructured sensitive coatings 显示文摘 | Corres J M Arregui F J Matias I R | 2007 | Sensors and Actuators B2007，，122： | 1 |
| 17 | The positive effect of immuno- suppression on adaptation of venous allografts to arterialisation in rats 显示文摘 | Matia I Varga M Lodererova A | 2010 | Eur J Vase Endovasc Surg2010，39，4： | 1 |
| 18 | Culture of microalgae using interstitial water extracted from shrimp pond bottom sediments 显示文摘 | Yusoff F M Matias H B Khalid Z A | 2001 | Aquaculture2001，201，： | 1 |
| 19 | Laparoscopic treatment of ureterolithiasis:our experience显示文摘 | Matias DB Alvim RG Ribas M | 2009 | Actas Urol Esp2009，33，6： | 1 |
| 20 | Phytoplankton succession in intensive marine shrimp culture ponds treated with a commercial bacterial product 显示文摘 | Yusoff F M Zubaidah M S Matias H B | 2002 | Aquac Res2002，33，4： | 1 |
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