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| 1 | Effectiveness of royal jelly supplementation in glycemic regulation:A systematic review显示文摘BACKGROUND Royal jelly(RJ)has been observed to have therapeutic properties in diabetic individuals,including the reduction of high blood sugar.This systematic review synthesized existing evidence to investigate the effectiveness of RJ supplementation in managing measures of blood glucose.AIM To determine the effectiveness of RJ supplementation on glycemic responses in healthy and non-insulin dependent diabetic adults,as well as animal models of diabetes.METHODS This was a systematic review employing the PRISMA strategy.Peer-reviewed,published articles were extracted from several databases using key words related to target population,intervention and outcome and hand-selected for inclusion.Included articles proceeded to data extraction phase,where information on target parameters and effectiveness of treatment was summarized.Following this,the risk of bias for each included study was evaluated.Then,the long-term and immediate effectiveness of RJ supplementation in glycemic control were assessed using the Grading of Recommendations,Assessment,Development and Evaluations(GRADE)tool,which rates the quality of evidence.RESULTS Of 168 articles extracted from database searching,eighteen were included for analysis in this systematic review.Across the studies,studied populations,intervention styles and outcome measures were largely heterogeneous.Despite this,the results in studies indicate a general trend of positive effect of RJ in glycemic regulation in vitro and in vivo.Additionally,some dose-dependent glycemic effects were observed,along with some large effect sizes.The risk of bias for human and animal studies is generally low-unclear risk,although lack of blinding is a serious concern in both categories.Overall,as per the GRADE tool,the quality of evidence is low,and very low for long-term and immediate effectiveness of RJ,respectively.A major limitation affecting evidence quality is the heterogeneity among included studies.Fasting blood glucose and glucose clearance appear to be most affected by RJ supplementation.CONCLUSION Quality of evidence suggesting that RJ is an effective modulator of glycemic regulation is low for long-term effects of RJ,and very low for immediate effects. | Kamel Omer Maxwell J Gelkopf Genevieve Newton | 2019 | World Journal of Diabetes2019，10，2： | 3 |
| 2 | Luminescent quantum dots for multiplexed biological detection and imaging显示文摘 | Warren C.W Chan Dustin J Maxwell Xiaohu Gao Robert E Bailey Mingyong Han Shuming Nie | 2002 | Current Opinion in Biotechnology2002，，1： | 2 |
| 3 | Stable implicit motor processes despite aerobic locomotor fatigue显示文摘 | MASTERS R S W POOLTON J M MAXWELL J P | 2008 | Consciousness and cogni- tion2008，17，： | 1 |
| 4 | Tissue temperatures during ultrasound--assisted lipoplasty 显示文摘 | Gingrass MK Perry LC Fisher J Maxwell GP | 1998 | Plast Reconstr Surg1998，102，2： | 1 |
| 5 | Expression of androgen and progesterone receptors in primary human meningiomas 显示文摘 | GALANOPOULUS T NEVILE G J | 1993 | J Neurosurg1993，78，3： | 1 |
| 6 | Development and Testing of the OPLS All-Atom Force Field onconformational Energetics and Properties of Organic Liquids显示文摘 | JORGENSEN W L MAXWELL D S TIRADO-RIVES J | 1996 | J Am Chem Soc1996，118，11： | 1 |
| 7 | Laterally-bridged bisporphyrin system显示文摘 | Maxwell J C Paul L B Rigid | 1987 | J Chem Soc Chem Commun1987，39，： | 1 |
| 8 | Development and validation of a Chinese version of the Buss-Perry Aggression Questionnaire显示文摘 | MAXWELL J P | 2007 | Personal Assessm2007，88，3： | 1 |
| 9 | Valuation and management of wetland ecosystems显示文摘 | Costanza R Farber S C Maxwell J | 1989 | Ecological Economics1989，1，33： | 1 |
| 10 | Effects of dietary magnesium and short-duration transportation on stressresponse,postmortem muscle metabolism,and meat quality of finishing swine显示文摘 | Apple J K Kegley E B Maxwell C V Jr | 2005 | J Anim Sci2005，83，7： | 1 |
| 11 | Refinancing risk and cash holdings显示文摘 | Harford J Klasa S Maxwell F W | 2014 | Journal of Finance2014，69，2： | 1 |
| 12 | The Implicit Benefit of Learning Without Errors显示文摘 | Maxwell J P Masters R S W Kerr E Weedon E | 2001 | Quarterly Journal of Experimental Psychology2001，54，4： | 1 |
| 13 | De-sign and Demonstration of a High Authority ShapeMorphing Structure显示文摘 | dos Santos e Lucato Wang J Maxwell P | 2004 | International Journal ofSolids and Structures2004，41，13： | 1 |
| 14 | Carcinoma of the rectum:a 10-year experience显示文摘 | Dixon A R Maxwell W A Holmes J T | 1991 | Br J Surg1991，78，3： | 1 |
| 15 | NOS inhibition acceler- ates atherogenesis: reversal by exercise 显示文摘 | Niebauer J Maxwell A J Lin P S | 2003 | Am J Physiol Heart Cire Physiol2003，285，2： | 1 |
| 16 | Non-invasive imaging of combretastatin ac- tivity in two tumor models: association with invasive estimates 显示文摘 | Nielsen T Murata R Maxwell R J Stedkilde-Jorgensen H Oster- gaard L Ley CD etal | 2010 | Acta Oncol2010，49，7： | 1 |
| 17 | Determination of sarafloxacin residues in fortified and incurred eggs using on-line microdialysis and HPLC/programmable fluorescence detection显示文摘 | Maxwell R J Cohen E Donoghue D J | 1999 | Journal of Agricultural and Food Chemistry1999，47，4： | 1 |
| 18 | Species variation in the coronary collateral circulation during regional myocardial ischaemia:a infarction显示文摘 | Maxwell M P Hearse D J Yellon D M | | 0，，10： | 1 |
| 19 | Ultrasound-guided vacuum-assisted excision of breast papillomas:review of 6-years experience显示文摘 | MAXWELL A J | 2009 | Clinical radiology2009，64，8： | 1 |
| 20 | The hypoxiaresponse pathway and p- cell function 显示文摘 | Cantley J Grey S T Maxwell P H M a/ | 2010 | DiabetesObes Metab2010，，2： | 1 |
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