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| 1 | Chemopreventive and Growth Inhibitory Effects of Selenium显示文摘There is very convincing evidence that a high dietary level of selenium substantially reduces the incidence of a wide variety of animal cancers. The human epidemiological evidence is less clear cut, but overall suggests that selenium may be protective: the evidence is strongest in men in relation to gastro-intestinal cancers. There is evidence that dietary selenium compounds reduce the formation of DNA adducts by carcinogens. Selenium compounds also inhibit growth in vitro and induce apoptosis. In general, there is a good correlation between the effectiveness of selenium compounds in chemoprevention and growth inhibition, implying that the mechanisms of growth inhibition and chemoprevention may be similar and that a major factor in the chemopreventive effects of selenium compounds in vivo is their ability to retard outgrowth of pre-malignant cells. Various hypotheses have been advanced as to how selenium compounds might prevent tumour cellgrowth. One is that they cause apoptosis by inducing oxidative stress. However, we have shown that the most potent selenium compound, selenodiglutathione (SDG), a natural metabolite of selenite, does not induce oxidative stress, at least not in the sarne way as other oxidants such as H2O2 and diamide. Firstly, a partially selenium-resistant variant cell line does not show increased resistance to H2O2. Moreover, SDG does not induce widespread tyrosine phosphorylation, including MAP and SAN kinases, like other oxidants such as H2O2 and diamide and its effects are not reversed by pretreatment with the tyrosine kinase inhibitor, herbimycin. Our experiments with the selenium-resistant variant suggest that a novel selenium-binding protein may be involved in growth inhibition by | P. R. HARRISON J. LANFEAR L. WU J. FLEMING L. MCGARRY, AND L. BLOWER (The Beatson Institute for Cancer Research, CRC Beatson Laboratories, Garscube Estate, Switchback Road,Bearsden, Glasgow, G61 1BD, Scotland, UK) | 1997 | Biomedical and Environmental Sciences1997，10，2： | 5 |
| 2 | 腺苷酸活化蛋白激酶病酷似肥厚性心肌病和预激综合征:自然病史 | Murphy R.T. Mogensen J. McGarry K. W.J. McKenna 吴波 | 2005 | 世界核心医学期刊文摘(心脏病学分册)2005，0，9： | 3 |
| 3 | Ezetimibe coadministered with simvastatin In patients with primary hypercholesterolemia显示文摘 | DAVIDSON MH MCGARRY T BETTIS R | 2002 | J Am Coll Cardiol2002，40，12： | 1 |
| 4 | Expression of an exogenous human Oct-4 promoter identifies tumor- initiating cells in osteosarcoma 显示文摘 | Levings PP McGarry SV Currie TP | 2009 | Cancer Res2009，69，14： | 1 |
| 5 | Blockade of vascular smooth muscle cell proliferation and intimal thickening after balloon injury by the sulfated oligosaccharide PI-88:phosphomannopentaose sulfate directly binds FGF-2,blocks cellular signaling,and inhibits proliferation显示文摘 | Francis DJ Parish CR McGarry M | 2003 | Circ Res2003，92，8： | 1 |
| 6 | A causative relationship exists between eosinophils and the development of allergic pulmonary pathologies in the mouse显示文摘 | Shen H Ochkur SI McGarry MP | 2003 | JImmunol2003，170，： | 1 |
| 7 | General findings of the International Atherosclerosis project显示文摘 | McGarry PA McMahan CA Montenegro MR | 1968 | Lab Invest1968，18，： | 1 |
| 8 | Automated trend analysis of proteomics data using an intelligent data mining architecture显示文摘 | MALDNE J MCGARRY K BOWERMAN C | 2006 | Expert Systems with Applications2006，30，1： | 1 |
| 9 | Influence of dis- tinct anatomic subregions of the supraspinatus on humeral rotation显示文摘 | Gates JJ Gilliland J McGarry MH | 2010 | J Orthop Res2010，28，1： | 1 |
| 10 | Biomechanical effects of patellar positioning on intraoperative knee joint gap measurement in total knee ar- throplasty显示文摘 | Gejo R Mcgarry MH Jun BJ | 2010 | Clin Biomech(Bristol Avon)2010，25，4： | 1 |
| 11 | Impact of obesity on revascularization and restenosis rates after bare-metal and drug-eluting stent implantation (from the TAXUS-IV trial)显示文摘 | Eugenia Nikolsky Edward Kosinski Gregory J. Mishkel Carey Kimmelstiel Thomas F. McGarry Roxana Mehran Martin B. Leon Mary E. Russell Stephen G. Ellis Gregg W. Stone | 2005 | The American Journal of Cardiology2005，，6： | 1 |
| 12 | The epide- miology and chrono-biology of epistaxis : An investigation of Scottish hospital admissions 1995-2004 显示文摘 | Walker T W Mccfarlane T V Mcgarry G W | 2007 | Clin Oto- laryngol2007，32，5： | 1 |
| 13 | Banting Leceure 2001 :dysregulation of fatty acid metabolism, in the etiology of type 2 diabetes显示文摘 | McGarry JD | 2002 | Diabetes2002，51，： | 1 |
| 14 | Exposure to parti- cles from laser printers operating within office work- places 显示文摘 | McGarry P Morawska L He C | 2011 | Environmental Science & Technology2011，45，15： | 1 |
| 15 | Maximising graduatestatus in pre-registration nursing programmes : utilising problembased leaming显示文摘 | McGarry J Aubeeluck A James V | 2011 | Nurse Educ Pract2011，11，6： | 1 |
| 16 | Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis 显示文摘 | McGarry TJ Bernal T | 1999 | Science1999，285，5426： | 1 |
| 17 | Banting lecture2001 : dysregulation of fatty acid metabolism in the etiology of type2 diabetes 显示文摘 | McGarry JD | 2002 | Diabetes2002，51，1： | 1 |
| 18 | Cost-effectiveness analysis of universal influenza vacci- nation with quadrivalent inactivated vaccine in the Unit- ed States 显示文摘 | CLEMENTS K M MEIER G MCGARRY L J | 2014 | Hum Vaccin Immunother2014，10，5： | 1 |
| 19 | A new frac- ture model for' terrible triad' injuries of the elbow: in- fluence of forearm rotation oninjury patterns显示文摘 | Fitzpatrick MJ Dihz M McGarry MH | 2012 | J Orthop Trauma2012，10，6： | 1 |
| 20 | Banting lecture 2001 : dysregulation of fatty acid me-tabolism in the etiology of type 2 diabetes显示文摘 | McGarry JD | 2002 | Diabetes2002，51，1： | 1 |
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