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| 1 | Endocrine impact of Helicobacter pylori:Focus on ghrelin and ghrelin o-acyltransferase显示文摘Ghrelin is predominantly produced by the gastric enteroendocrine cell compartment and is octanoylated by the recently discovered ghrelin o-acyltransferase (GOAT) before secretion into the bloodstream. This octanoylation is essential for many of the biological properties of ghrelin including appetite stimulation and anti-inflammatory properties as only the acylated form of ghrelin binds to the ghrelin receptor, the growth hormone secretagogue receptor (GHS-R). Given the gastric location of ghrelin production, it is perhaps not surprising that insult to the gastric mucosa affects circulating ghrelin levels in humans. Helicobacter pylori (H. pylori) infects more than f ifty percent of the world's population and once established within the gastric mucosa, can persist for life. Infection is associated with chronic gastritis, gastric atrophy and ulceration, reduced appetite and a lower body mass index (BMI). The large majority of studies investigating levels of circulating ghrelin and ghrelin expression in the stomach in patients with H. pylori infection indicate that the bacterium has a negative impact on ghrelin production and/or secretion. Eradication of infection restores ghrelin, improves appetite and increases BMI in some studies, however, a causative relationship between H. pylori-associated serum ghrelin decline and food intake and obesity has not been established. Most studies measure total ghrelin in the circulation although the measurement of the ratio of acyl/total ghrelin gives a clearer indication that the ghrelin acylation process is altered during infection and atrophy. GOAT is essential for the production of biologically-active, acyl ghrelin and the impact of H. pylori on GOAT expression and activity will be highly informative in the future. | Penny L Jeffery Michael A McGuckin Sara K Linden | 2011 | World Journal of Gastroenterology2011，17，10： | 12 |
| 2 | Muc1 Mucin Limits Both Helicobacter pylori Colonization of the Murine Gastric Mucosa and Associated Gastritis显示文摘 | Michael A. McGuckin Alison L. Every Caroline D. Skene Sara K. Linden Yok Teng Chionh Agnieszka Swierczak Julie McAuley Stacey Harbour Maria Kaparakis Richard Ferrero Philip Sutton | 2007 | Gastroenterology2007，，4： | 2 |
| 3 | ER stress and the unfolded protein response in intestinal inflammation 显示文摘 | McGuckin M A Eri R D Das I | 2010 | Am J Physiol Gastrointest Liver Physiol2010，298，： | 1 |
| 4 | The effect of random voice hand hygiene messages delivered by medical,nursing,and infection control staff on hand hygiene compliance in intensive care显示文摘 | McGuckin M Shubin A McBride P | | 0，，10： | 1 |
| 5 | Increased predicted losses of phosphorus to surface waters from soils with high Ols en-P concentrations 显示文摘 | Jordan C McGuckin S O Smith R V | 2000 | Soil Use and Management2000，，16： | 1 |
| 6 | Indications for and Outcomes of Cholecystectomy: A Comparison of the Pre and Postlaparoscopic Eras显示文摘 | Judy A. Shea Jesse A. Berlin Dale R. Bachwich Rudolf N. Staroscik Peter F. Malet Maryanne McGuckin J. Sanford Schwartz José J. Escarce | 1998 | Annals of Surgery1998，，3： | 1 |
| 7 | The effect of random voice hand hygiene messages delivered by medical, nursing, and infec- tion control staff on hand hygiene compliance in intensive care 显示文摘 | McGuckin M Shubin A McBride P | 2006 | Am J Infect Control2006，34，10： | 1 |
| 8 | Production of stem cells with embryonic characteristics from human umbilical cord blood 显示文摘 | McGuckin CP Forraz N Baradez MO | 2005 | CellProliferation2005，38，4： | 1 |
| 9 | Increasing handwashing compliance with more accessible sinks显示文摘 | Kaplan LM McGuckin M | 1986 | Infect Control1986，7，： | 1 |
| 10 | Umbilical cord blood stem cells can expand hematopoietic and neuroglial progenitors in vitro 显示文摘 | McGuckin C P Forraz N Allouard Q | 2004 | Exp Cell Res2004，295，2： | 1 |
| 11 | Structure andfunction of the polymeric mucins in airways mucus显示文摘 | Thornton DJ Rousseau K McGuckin MA | 2008 | Annu Rev Physiol2008，70，： | 1 |
| 12 | Expression of muc2 epithelial mucin in breast carcinoma显示文摘 | Walsh M D McGuckin M A Devine P L | 1993 | Journal of Clinical Pathology1993，46，10： | 1 |
| 13 | Patient education model for increasing hangwashing compliance显示文摘 | McGuckin M Waterman R Porten L | 1999 | Am J Infect Control1999，27，4： | 1 |
| 14 | Prognostic significance of MUC1 epithelial mucin expression in breast cancer显示文摘 | McGuckin MA Walsh MD Hohn BG | 1995 | Hum Pathol1995，26，： | 1 |
| 15 | Occult axillary node metastases in breast cancer:their detection and prognostic significance 显示文摘 | Cummings MC Walsh MD | 1996 | Br J Cancer1996，73，1： | 1 |
| 16 | A generalized production frontier approach for estimating determinants of inefficiency in US dairy farms 显示文摘 | Kumbhakar S Ghosh S McGuckin J | 1991 | Journal of Business and Economic Statistics1991，，9： | 1 |
| 17 | Rituximab for thrombotic thrombocytopenic purpura:benefit of early administration during acute episodes and use of prophylaxis to prevent relapse显示文摘 | Westwood JP Webster H Mcguckin S | 2013 | J Thromb Haemost2013，11，3： | 1 |
| 18 | Spontaneous apoptosis of blood dendritic cells in patients with breast cancer 显示文摘 | Pinzon -Charry A Maxwell T McGuckin MA | 2006 | Breast Cancer Res2006，8，1： | 1 |
| 19 | Occult axillary node metastases in breast cancer: their detection and prognostic significance显示文摘 | Mcguckin MA Cummings MC Walsh MD | 1996 | Br J Cancer1996，73，1： | 1 |
| 20 | Spontaneous apoptosis of blood dendritic cells in patients with breast cancer显示文摘 | Pinzon-Charry A Maxwell T McGuckin MA | 2006 | Breast Cancer Res2006，8，1： | 1 |
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