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509篇 您的检索式:作者名="MCKENZIE L"
    题名 作者 年代 出处 被引量
1NOD2 and ATG16L1 polymorphisms affect monocyte responses in Crohn's disease显示文摘AIM:To assess whether polymorphisms in NOD2 and ATG16L1 affect cytokine responses and mycobacterium avium subspecies paratuberculosis (MAP) survival in monocytes from Crohn's disease (CD) patients.METHODS:Monocytes were isolated from peripheral blood of CD patients of known genotype for common single nucleotide polymorphisms of NOD2 and ATG16L1.Monocytes were challenged with MAP and bacterial persistence assessed at subsequent time-points.Cytokine responses were assayed using a Milliplex multi-analyte profiling assay for 13 cytokines.RESULTS:Monocytes heterozygous for a NOD2 polymorphism (R702W,P268S,or 1007fs) were more permissive for growth of MAP (P=0.045) than those without.There was no effect of NOD2 genotype on subsequent cytokine expression.The T300A polymorphism ofATG16L1 did not affect growth of MAP in our model (P=0.175),but did increase expression of cytokines interleukin (IL)-10 (P=0.047) and IL-6 (P=0.019).CONCLUSION:CD-associated polymorphisms affected the elimination of MAP fromex vivo monocytes (NOD2),or expression of certain cytokines (ATG16L1),implying independent but contributory roles in the pathogenesis of CD.Dylan M Glubb Richard B Gearry Murray L Barclay Rebecca L Roberts John Pearson Jacqui I Keenan Judy McKenzie Robert W Bentley 2011World Journal of Gastroenterology2011,17,23:2
2The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17^+ T helper cells显示文摘Ivanov II McKenzie BS Zhou L 2006Cell2006,126,:1
3Relationship between system-level characteristics of assisted living facilities and the health and safety of unlicensed staff显示文摘McKenzie G L Teri L Salazar M K 2011AAOHNJ2011,59,4:1
4A potent new class of reductively activated peptide gene delivery agents显示文摘McKenzie D L Kwok K Y Rice K G 2000J Biol Chem2000,275,14:1
5Chang: in ultraviolet radiation reaching the earth's surface 显示文摘Madronieh S Mckenzie R L Caldwell M M 1995AMBIO1995,24,:1
6Effect of upper extremity exer- cise on secondary lymphedema in breast cancer patients: a pi- lot study 显示文摘McKenzie D C Kalda A L 2003J Clln Chacol2003,21,3:1
7The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells显示文摘Ivanov McKenzie BS Zhou L 0,,6:1
8Temporal carbon dynamics of forests in Washington, US : Implications for ecological theory and carbon management显示文摘Raymond C L McKenzie D 2013Forest Ecology and Management2013,310,:1
9Cloud coverage based on all-sky imaging and its impact on surface solar irradianee 显示文摘Pfister G McKenzie R L Liley J B 2003Journal of Applied Meteorology2003,42,10:1
10Changes in biologically-active ultraviolet radiation reaching the Earth's surface 显示文摘McKenzie R L Aucamp P J Bais A F 2007Photochemical and Photobiological Sciences2007,6,3:1
11The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL- 17^+ T helper cells 显示文摘Ivanov I I McKenzie B S Zhou L 2006Cell2006,126,:1
12The SOS response regulates adaptive mutation显示文摘McKenzie G J Harris B S Lee P L 2000Proc Natl Acad Sci USA2000,97,:1
13Susceptibility of Aphis gossypii (Glover) Lo insecticides as affected by host plant using a rapid bioassay 显示文摘McKenzie C L Cartwright B 1994J Entomol Sci1994,29,3:1
14The orphan nuclear receptor RORgammat directs the differentiation program of pro - inflammatory IL - 17 + T helper ceils 显示文摘Ivanov I I McKenzie B S Zhou L 2006Cell2006,126,6:1
15An unified approach to solving the harmonic elimination equations in multilevel converters显示文摘CHIASSON J N TOLBERT L MCKENZIE K J 2004IEEE Transactions on Power Electronics2004,19,2:1
16Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP显示文摘KRISHNAMURTHY B DUDEN N L MCKENZIE M D 2006J Clin Invest2006,116,:1
17The orphan nuclear receptor RORγt directs the differrentiation program of proinflammatory IL-17 ^+ T helper cells显示文摘Ivanov II McKenzie BS Zhou L 2006Cell2006,126,6:1
18The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells显示文摘Ivanov I McKenzie B Zhou L 2006Cell2006,126,6:1
19Solar observations from the P78-1 satellite显示文摘MCKENZIE D L LANDECKER P B 1982Astrophys J1982,254,:1
20Changes in biologicelly-active ultraviolet radiation reaching the Earth's surface显示文摘McKenzie R L Aucamp P J Bais A F 2007Photochemical and Photobiological Sciences2007,6,:1
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