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| 1 | -765G > C COX-2 polymorphism may be a susceptibility marker for gastric adenocarcinoma in patients with atrophy or intestinal metaplasia显示文摘AIM: To investigate the relationship between the -765G > C COX-2 polymorphism and the development of different gastric lesions: atrophy or intestinal metaplasia and gastric adenocarcinoma. METHODS: A cross-sectional study was performed involving 320 Portuguese individuals (210 without evidence of neoplastic disease, 73 patients with gastric adenocarcinomas and 37 with atrophy or intestinal metaplasia) using a PCR-RFLP method. RESULTS: -765C allele was overrepresented in the patients with gastric adenocarcinoma (51%) when compared either with the control group (38%) or patients with atrophy or intestinal metaplasia (27%). Callele was found to be very common in our population (0.22), and a multivariate logistic regression analysis revealed nearly 3-fold increased risk for the progression to gastric adenocarcinoma in patients with atrophy or intestinal metaplasia carrying the -765C allele (OR = 2.67, 95% CI = 1.03-6.93; P = 0.04).considered as another susceptibility marker for gastric adenocarcinoma development in patients with atrophy or intestinal metaplasia. | Carina Pereira Hugo Sousa Paula Ferreira Maria Fragoso Luís Moreira-Dias Carlos Lopes Rui Medeiros Mário Dinis-Ribeiro | 2006 | World Journal of Gastroenterology2006，12，34： | 16 |
| 2 | Gastric cancer in a Caucasian population: Role of pepsinogen C genetic variants显示文摘瞄准:在胃蛋白酶原 C (PGC ) 基因学习插入 / 删除多型性的角色,为胃粘膜的终端区别的一个有效标记,在到胃的损害的开发的危险性。方法:没有肿瘤的疾病的证据,学习与已知的胃的损害的 99 件样品和 127 件样品被执行。PCR 被采用, 6 多态的等位基因被放大:等位基因 1 (510 bp ) ,等位基因 2 (480 bp ) ,等位基因 3/4 (450/460 bp ) ,等位基因 5 (400 bp ) 并且等位基因 6 (310 bp ) 。结果:我们的结果表明等位基因 6 搬运人似乎对任何胃的损害的发展有保护(或 = 0.34;P<0.001 ) ,与象萎缩或肠的组织变形那样的胃的腺癌联系的 non-dysplastic 损害(或 = 0.28;P<0.001 ) 或侵略 GC (或 = 0.39;P = 0.004 ) 。结论:我们的学习表明等位基因 6 搬运人地位在胃的损害的发展有一个保护的角色,可能由于它有 PGC 的更高的表示的协会。而且,在控制组的等位基因 6 搬运人的频率比在亚洲人口获得了高是远的,它可能代表在白种人和亚洲人口之间的基因差距。 | Ana L Pinto-Correia Hugo Sousa Maria Fragoso Luís Moreira-Dias Carlos Lopes Rui Medeiros Mário Dinis-Ribeiro | 2006 | World Journal of Gastroenterology2006，12，31： | 6 |
| 3 | Association between EGF +61A/G polymorphism and gastric cancer in Caucasians显示文摘AIM: To investigate the association between epidermal growth factor (EGF) +61A/G polymorphism and susceptibility to gastric cancer, through a cross-sectional study. METHODS: Polymerase chain reaction resctriction fragment lenght polymorphism analyses were used to genotype EGF +61 in 207 patients with gastric lesions (162 patients with gastric adenocarcinomas, 45 with atrophy or intestinal metaplasia) and 984 controls. All subjects were Caucasian. RESULTS: Genotype distribution was 23.5% for GG and 76.5% for GA/AA in the control group, 18.4% for GG and 68.6% for GA/AA in the entire group with gastric lesions and 17.9% for GG and 82.1% for GA/AA in the group with gastric adenocarcinoma. No statistically significant associations were found between EGF +61 variants and risk for developing gastric cancer [odds ratios (OR) = 1.41, 95% confidence intervals (CI): 0.90-2.21, P = 0.116]. However, the stratification of individuals by gender revealed that males carrying A alleles (EGF +61A/G or AA) had an increased risk for developing gastric cancer as compared to GG homozygous males (OR = 1.55, 95% CI: 1.05-2.28, P = 0.021). CONCLUSION: In summary, we found that males who were A carriers for EGF +61 had an increased risk for developing gastric cancer. This result may be explained by the suggestion that women secrete less gastric acid than men. | Ana Paula Araújo Bruno M Costa Ana L Pinto-Correia Maria Fragoso Paula Ferreira Mário Dinis-Ribeiro Sandra Costa Rui M Reis Rui Medeiros | 2011 | World Journal of Gastroenterology2011，17，4： | 3 |
| 4 | Magnesium-solution phase catholyte semi-fuel cell for undersea vehicles显示文摘 | MEDEIROS M G BESSETTE R R DESHENES C M | 2004 | Journal of Power Sources2004，136，： | 1 |
| 5 | Quantifying process equivalence based on ob- served behavior 显示文摘 | ALVES DE MEDEIROS A K van der AALST W M P WEIJTERS A | 2008 | Data and Knowledge Engineering2008，64，1： | 1 |
| 6 | Reinforced concrete in marine environmentEffect of wetting and drying cycles,height and positioning in relation to the sea shore显示文摘 | MEDEIROS M H F GOBBI A RIUS G C | 2013 | Construction and Building Materials2013，44，： | 1 |
| 7 | Periodic Solutions for Nonlinear Systems with Mean Curvature-Like Operators显示文摘 | Benevieri P DoO J M Medeiros E S D | 2006 | Nonlinear Analysis:Real Word Applications2006，65，7： | 1 |
| 8 | Stimuli-responsive magnetic particles for biomedical applications显示文摘 | Medeiros S F Santos A M Fessi H | | 0，，1： | 1 |
| 9 | Hospital-acquired me- ningitis in patients undergoing craniotomy: incidence, evolution, and risk factors显示文摘 | Reichert M C Medeiros E A Ferraz F A | 2002 | Am J Infect Control2002，30，3： | 1 |
| 10 | Periodic Solutions for Nonlinear Equations with Mean Curvature-like Operators显示文摘 | Benevieri P DoO J M Medeiros E S D | 2007 | Applied Mathematics Letters2007，20，5： | 1 |
| 11 | Magnesium- solution phase catholyte semi -fuel cell for under- sea vehicles显示文摘 | Medeiros M G Bessette R R Deschenes C M | 2004 | Journal of Power Sources2004，136，： | 1 |
| 12 | Enzymatic hydrolysis of cellulose: Evaluation of cellulase culture filtrates under use conditions显示文摘 | MANDELS M MEDEIROS J E ANDREOTTI R E | 1981 | Biotechnology and Bioengineering1981，23，9： | 1 |
| 13 | Screening of yeasts for production of xylitol from D-xylose and some factors which affect xylitol yield in Candida guilliermondii显示文摘 | BARBOSA M F S MEDEIROS M B MANCILHA I M | 1988 | Journal of Industrial Microbiology1988，3，： | 1 |
| 14 | Genetic process mining:an experimental evaluation显示文摘 | DE MEDEIROS A K A WEIJTERS A J M M VAN DER AALST W M P | 2007 | Data Mining and Knowledge Discovery2007，14，2： | 1 |
| 15 | Magnesium - solution phase cath- olyte seawater electrochemical system 显示文摘 | Medeiros M G Dow E G | 1999 | Journal of Power Sources1999，80，： | 1 |
| 16 | Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome显示文摘 | Amato M B Barbas C S Medeiros D M | 1998 | N Engl J Med1998，338，： | 1 |
| 17 | An outline of inherited disorders of the thyroid hormone generating system显示文摘 | Knobel M Medeiros - Neto G | 2003 | Thyroid2003，13，： | 1 |
| 18 | Accuracy of telomerase in estimating breast cancer risk: a systematic review and metaanalysis显示文摘 | Winnikow E P Medeiros L R Edelweiss M I | 2012 | Breast2012，21，1： | 1 |
| 19 | Overexpression of follistatin in trout stimulates increased muscling显示文摘 | Medeiros E F Phelps M P Fuentes F D | 2009 | American Journal of Physiology-regulatory Integrative and ComparativePhysiology2009，297，： | 1 |
| 20 | Source profiles of organic compounds emitted upon combustion of green vegetation from temperate climate forests 显示文摘 | Medeiros P M and Simoneit B R T | 2008 | Environmental Science & Technology2008，42，22： | 1 |
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