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| 1 | Cholangiocyte anion exchange and biliary bicarbonate excretion显示文摘主要小管胆汁沿着被几个因素包括荷尔蒙, innervation/neuropeptides,和胆汁的成分影响的胆道经历使液化和硷化的一个过程。在 canaliculi 和胆汁管的酸式碳酸盐的排泄是到所谓的胆汁盐独立人士流动的产生的一个重要贡献者。酸式碳酸盐通过经由 AE2/SLC4A2-mediated Cl-/HCO3- 交换通过 Cl- 隧道,和进一步的酸式碳酸盐分泌物的激活包含氯化物流出的平行机制从 hepatocytes 和 cholangiocytes 被分泌。高血糖素和分泌素是似乎在他们的目标房间(为前者的 hepatocytes 和为后者的 cholangiocytes ) 很同样行动的二相关荷尔蒙。这些荷尔蒙与他们的特定的 G 联合蛋白质的受体交往,引起营地的细胞内部的层次和营地依赖者 Cl- 和 HCO3- 的激活的增加能分泌的机制。hepatocytes 和 cholangiocytes 看起来有在的营地应答的细胞内部的泡有房间 specific Cl- 隧道的 AE2/SLC4A2 colocalizes (在 cholangiocytes 并且还没的 CFTR 在 hepatocytes 决定了) 并且 aquaporins (在 hepatocytes 的 AQP8 和在 cholangiocytes 的 AQP1 ) 。到小管或 cholangiocyte lumenal 膜和进一步的 exocytosis 的这些泡的导致营地的协调交通国王与网导致水的增加的渗透的力量和被运动充满酸式碳酸盐的胆液排泄增多。 | Jesús M Banales Jesús Prieto Juan F Medina | 2006 | World Journal of Gastroenterology2006，12，22： | 10 |
| 2 | Aminoguanidine impedes human pancreatic tumor growth and metastasis development in nude mice显示文摘AIM:To study the action of aminoguanidine on pancreatic cancer xenografts in relation to cell proliferation,apoptosis,redox status and vascularization.METHODS:Xenografts of PANC-1 cells were developed in nude mice. The animals were separated into two groups:control and aminoguanidine treated. Tumor growth,survival and appearance of metastases were determined in vivo in both groups. Tumors were excised and ex vivo histochemical studies were performed. Cell growth was assessed by Ki-67 expression. Apoptosis was studied by intratumoral expression of B cell lymphoma-2 protein (Bcl-2) family proteins and Terminal deoxynucleotidyl transferase biotin-dUTP Nick End Labeling (Tunel). Redox status was evaluated by the expression of endothelial nitric oxide synthase (eNOS),catalase,copper-zinc superoxide dismutase (CuZnSOD),manganese superoxide dismutase (MnSOD) and glutathione peroxidase (GPx). Finally,vascularization was determined by Massons trichromic staining,and by VEGF and CD34 expression.RESULTS:Tumor volumes after 32 d of treatment by aminoguanidine (AG) were significantly lower than in control mice (P < 0.01). Median survival of AG mice was significantly greater than control animals (P < 0.01). The appearance of both homolateral and contralateral palpable metastases was significantly delayed in AG group. Apoptotic cells,intratumoral vascularization (trichromic stain) and the expression of Ki-67,Bax,eNOS,CD34,VEGF,catalase,CuZnSOD and MnSOD were diminished in AG treated mice (P < 0.01),while the expression of Bcl-2 and GPx did not change.CONCLUSION:The antitumoral action of aminoguanidine is associated with decreased cell proliferation,reduced angiogenesis,and reduced expression of antioxidant enzymes. | Nora A Mohamad Graciela P Cricco Lorena A Sambuco Máximo Croci Vanina A Medina Alicia S Gutiérrez Rosa M Bergoc Elena S Rivera Gabriela A Martín | 2009 | World Journal of Gastroenterology2009，15，9： | 3 |
| 3 | Does laser surface texturing really have a negative impact on the fatigue lifetime of mechanical components?显示文摘Laser surface texturing(LST)has been proven to improve the tribological performance of machine elements.The micro-scale patterns manufactured by LST may act as lubricant reservoirs,thus supplying oil when encountering insufficient lubrication.However,not many studies have investigated the use of LST in the boundary lubrication regime,likely due to concerns of higher contact stresses that can occur with the increasing surface roughness.This study aims to examine the influence of LST on the fatigue lifetime of thrust rolling bearings under boundary lubrication.A series of periodic patterns were produced on the thrust rolling bearings,using two geometrically different designs,namely cross and dimple patterns.Base oil ISO VG 100 mixed with 0.05 wt%P of zinc dialkyldithiophosphate(ZDDP)was supplied.The bearings with cross patterns reduce the wear loss by two orders of magnitude.The patterns not only retain lubricant in the textured pockets but also enhance the formation of an anti-wear tribofilm.The tribofilm generation may be improved by the higher contact stresses that occur when using the textured surface.Therefore,in contrast to the negative concerns,the ball bearings with cross patterns were instead found to increase the fatigue life by a factor of three. | Chia-Jui HSU Andreas STRATMANN Simon MEDINA Georg JACOBS Frank MÜCKLICH Carsten GACHOT | 2021 | Friction2021，9，6： | 3 |
| 4 | Multimodality functional imaging using DW-MRI and 18F-FDG-PET/CT during radiation therapy for human papillomavirus negative head and neck squamous cell carcinoma: Meixoeiro Hospital of Vigo Experience显示文摘AIM To noninvasively investigate tumor cellularity measured using diffusion-weighted magnetic resonance imaging(DW-MRI) and glucose metabolism measured by 18 Flabeled fluorodeoxyglucose positron emission tomography/computed tomography(18F-FDG-PET/CT) during radiation therapy(RT) for human papillomavirus negative(HPV-) head and neck squamous cell carcinoma(HNSCC).METHODS In this prospective study, 6 HPV- HNSCC patients underwent a total of 34 multimodality imaging examinations(DW-MRI at 1.5 T Philips MRI scanner [(n = 24) pre-, during-(2-3 wk), and post-treatment(Tx), and 18F-FDG PET/CT pre- and post-Tx(n = 10)]. All patients received RT. Monoexponential modeling of the DW-MRI data yielded the imaging metric apparent diffusion coefficient(ADC) and the mean of standardized uptake value(SUV) was measured from 18F-FDG PET uptake. All patients had a clinical follow-up as the standard of care and survival status was documented at 1 year.RESULTS There was a strong negative correlation between the mean of pretreatment ADC(ρ =-0.67, P = 0.01) and the pretreatment 18F-FDG PET SUV. The percentage(%) change in delta(?) ADC for primary tumors and neck nodal metastases between pre- and Wk2-3 Tx were as follows: 75.4% and 61.6%, respectively, for the patient with no evidence of disease, 27.5% and 32.7%, respectively, for those patients who were alive with disease, and 26.9% and 7.31%, respectively, for those who were dead with disease.CONCLUSION These results are preliminary in nature and are indicative, and not definitive, trends rendered by the imaging metrics due to the small sample size of HPV- HNSCC patients in a Meixoeiro Hospital of Vigo Experience. | David Aramburu Núnez Antonio Lopez Medina Moisés Mera Iglesias Francisco Salvador Gomez Abhay Dave Vaios Hatzoglou Ramesh Paudyal Alfonso Calzado Joseph O Deasy Amita Shukla-Dave Victor M Munoz | 2017 | World Journal of Radiology2017，9，1： | 2 |
| 5 | Study of photodegradation of the pefticide ethiofencarb in aqueous and non - aqueous media, by gas chromatograghy - mass spectrometry 显示文摘 | J Sanze - Asensio M Plaza - Medina M T Martinez - Soria M Perez -Clavijo | 1999 | Journal of Chromatograghy A1999，84，： | 2 |
| 6 | Comparison of different sample treatments for the analysis of ochratoxin A in must, wine and beer by liquid chromatography显示文摘 | SAEZ J M MEDINA A JOSE V | 2004 | Journal of Chromatography A2004，1029，： | 1 |
| 7 | Contingent gene regulatory networks and B cell fate specification显示文摘 | Singh H Medina K L Pongubala J M | 2005 | Proc Natl Acad Sci2005，102，： | 1 |
| 8 | Downstream processing of polyunsaturated fatty acids显示文摘 | Medina A R Grima E M Gimenez A | 1998 | Biotechnology Advances1998，16，3： | 1 |
| 9 | Hemizygosity of deltacatenin (CTNND2) is associated with severe mental retardation in cridu-chat syndrome显示文摘 | Medina M Marinescu RC Overhauser J | 2000 | Genomics2000，63，2： | 1 |
| 10 | A three phase load flow algorithm for shipboard power systems 显示文摘 | Medina M M Qi L Butler-Purry K L | 2003 | Transmission and Distribution Conference and Exposition IEEE PES2003，1，712： | 1 |
| 11 | Rapamycin-eluting stent for the treatment of bifurcated coronary lesions:a randomized comparison of a simple versus complex strategy显示文摘 | Pan M DE Lezo JS Medina A | 2004 | Am Heart J2004，148，5： | 1 |
| 12 | Isolation of the three grape sub- lineages of B- class MADS- box TM6, PISTILLATA and APETALA3 genes which are differentially expressed during flower and fruit development显示文摘 | Poupin M J Federici E Medina C t al | 2007 | Gene2007，404，： | 1 |
| 13 | OncomiR addiction inan in vivo model of microRNA-21-induced pre-B-cell lymphoma显示文摘 | MEDINA P P NOLDE M SLACK F J | 2010 | Nature2010，467，： | 1 |
| 14 | SAGD: R&D for unlocking unconventional heavy-oil resources显示文摘 | Medina M | 2010 | The Way Ahead2010，6，2： | 1 |
| 15 | The new Olympus digital flexible ureteroscope (URF- V): Initial experience显示文摘 | Al-Qahtani S M Geavlete B de Medina S G | 2011 | Urol Ann2011，3，3： | 1 |
| 16 | Crop Residue Stabilization and Application to Agricultural and Degraded Soils:A Review显示文摘 | MEDINA J MONREAL C BAREA J M | 2015 | Waste Management2015，42，： | 1 |
| 17 | Applying petri nets in active database systems显示文摘 | LI XIAOOU MEDINA J M CHAPA S V | 2007 | IEEE Transactions on Systems Man and Cybernetics2007，37，4： | 1 |
| 18 | 显示文摘 | Colas B Le Meste M | 1992 | J Food Sci1992，57，3： | 1 |
| 19 | Linear transceiver design in nonregenerative relays with channel state information显示文摘 | Medina O M Vidal J Agustin A | 2007 | IEEE Trans on Signal Processing2007，55，6： | 1 |
| 20 | OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma显示文摘 | Medina PP Nolde M Slack FJ | 2010 | Nature2010，467，7311： | 1 |
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