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| 1 | Role of stem cell therapies in treating chronic wounds:A systematic review显示文摘BACKGROUND The impairment of cutaneous wound healing results in chronic,non-healing wounds that are caused by altered wound environment oxygenation,tissue injury,and permissive microbial growth.Current modalities for the treatment of these wounds inadequately address the complex changes involved in chronic wound pathogenesis.Consequently,stem cell therapies have emerged as a potential therapeutic modality to promote cutaneous regeneration through trophic and paracrine activity.AIM To investigate current literature regarding use of stem cell therapies for the clinical treatment of chronic,non-healing wounds.METHODS PubMed,EMBASE,Cochrane Library,Web of Science,and Scopus were queried with combinations of the search terms“mesenchymal stem cells,”“adult stem cells,”“embryonic stem cells,”“erythroid precursor cells,”“stem cell therapies,”and“chronic wounds”in order to find relevant articles published between the years of 2000 and 2019 to review a 20-year experience.Reference lists from the articles were reviewed to identify additional pertinent articles.Retrieved manuscripts(reviews,case reports/series,retrospective/prospective studies,and clinical trials)were evaluated by the authors for their depiction of clinical stem cell therapy use.Data were extracted from the articles using a standardized collection tool.RESULTS A total of 43 articles describing the use of stem cell therapies for the treatment of chronic wounds were included in this review.While stem cell therapies have been explored in in vitro and in vivo applications in the past,recent efforts are geared towards assessing their clinical role.A review of the literature revealed that adipose-derived stem cells,bone marrow-derived stem cells,bone marrowderived mononuclear cells,epidermally-derived mesenchymal stem cells,fibroblast stem cells,keratinocyte stem cells,placental mesenchymal stem cells,and umbilical cord mesenchymal stem cells have all been employed in the treatment of chronic wounds of various etiologies.Most recently,embryonic stem cells have emerged as a novel stem cell therapy with the capacity for multifaceted germ cell layer differentiation.With the capacity for self-renewal and differentiation,stem cells can enrich existing cell populations in chronic wounds in order to overcome barriers impeding the progression of wound healing.Further,stem cell therapies can be utilized to augment cell engraftment,signaling and activity,and resultant patient outcomes.CONCLUSION Assessing observed clinical outcomes,potential for stem cell use,and relevant therapeutic challenges allows wound care stakeholders to make informed decisions regarding optimal treatment approaches for their patients’chronic wounds. | Anjali C Raghuram Roy P Yu Andrea Y Lo Cynthia J Sung Melissa Bircan Holly J Thompson Alex K Wong | 2020 | World Journal of Stem Cells2020，12，7： | 5 |
| 2 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 3 | Immunogenetic factors driving formation of ultralong VH CDR3 in Bos taurus antibodies显示文摘The antibody repertoire of Bos taurus is characterized by a subset of variable heavy(VH)chain regions with ultralong third complementarity determining regions(CDR3)which,compared to other species,can provide a potent response to challenging antigens like HIV env.These unusual CDR3 can range to over seventy highly diverse amino acids in length and form uniqueβ-ribbon‘stalk’and disulfide bonded‘knob’structures,far from the typical antigen binding site.The genetic components and processes for forming these unusual cattle antibody VH CDR3 are not well understood.Here we analyze sequences of Bos taurus antibody VH domains and find that the subset with ultralong CDR3 exclusively uses a single variable gene,IGHV1-7(VHBUL)rearranged to the longest diversity gene,IGHD8-2.An eight nucleotide duplication at the 3′end of IGHV1-7 encodes a longer V-region producing an extended Fβ-strand that contributes to the stalk in a rearranged CDR3.A low amino acid variability was observed in CDR1 and CDR2,suggesting that antigen binding for this subset most likely only depends on the CDR3.Importantly a novel,potentially AID mediated,deletional diversification mechanism of the B.taurus VH ultralong CDR3 knob was discovered,in which interior codons of the IGHD8-2 region are removed while maintaining integral structural components of the knob and descending strand of the stalk in place.These deletions serve to further diversify cysteine positions,and thus disulfide bonded loops.Hence,both germline and somatic genetic factors and processes appear to be involved in diversification of this structurally unusual cattle VH ultralong CDR3 repertoire. | Thaddeus C Deiss Melissa Vadnais Feng Wang Patricia L Chen Ali Torkamani Waithaka Mwangi Marie-Paule Lefranc Michael F Criscitiello Vaughn V Smider | 2019 | Cellular & Molecular Immunology2019，16，1： | 4 |
| 4 | Interfirm Collabora- tion Networks: The Impact of Large-Scale Network Struc- ture on Finn Innovation显示文摘 | Melissa A Schilling Corey C Phelps | 2007 | Management Science2007，53，7： | 1 |
| 5 | Interfirm collaboration networks: The impact of small world connectivity on firm innovation显示文摘 | Schilling Melissa Corey C Phelps | 2007 | Management Science2007，53，： | 1 |
| 6 | Interfirm collaborationnetworics : The impact of large - scale network structure onfirm innovation 显示文摘 | Schilling Melissa A Phelps Corey C | 2007 | Management Science2007，53，7： | 1 |
| 7 | Re-appraising stress appraisals: The underlying properties of stress in sport显示文摘 | Joanne T Melissa C D | 2008 | Psychology of Sporl and Exercise2008，9，： | 1 |
| 8 | Reproductive toxicity evaluation of dietary butyl benzyl phthalate(BBP)in rats显示文摘 | Rochelle W T Christina B M Melissa C M | 2004 | Reproductive Toxicology2004，18，： | 1 |
| 9 | Synthe- sis, antifungal activity, and structure-activity relation- ships of coruscanone A analogues显示文摘 | BABU K B LI X C MELISSA R J | 2006 | J Med Chem2006，49，26： | 1 |
| 10 | Quantitation of the hydroxyl radical by reaction with dimethyl sulfoxide 显示文摘 | Melissa G S Babbs F C | 1990 | Archives of Biochemistry and Biophysics1990，278，2： | 1 |
| 11 | Characterization of the last deglacial transition in tropical East Afri显示文摘 | Melissa A B Thomas C J Josef P W | 2014 | Palaeogeography Palaeoclimatology Palaeoecology2014，409，： | 1 |
| 12 | Structure of hybrid (organic/inorganic) TiO2 SiO2 xerogels II:thermai behavior as monitored by temperature-programmed techniques and spectroscopy显示文摘 | LARSEN G MELISSA B S NGUYEN C | 2001 | J Non Cryst Solids2001，279，： | 1 |
| 13 | Secondhand smoke drift: Examining the influence of indoor smoking bans on indoor and outdoor air quality at pubs and bars 显示文摘 | Emily B Melissa C Charles W | 2010 | Nicotine & Tobacco Research2010，12，： | 1 |
| 14 | Modeled earthquake losses and social vulnerability in Charleston, South Carolina 显示文摘 | MATHEW C S JOHN M S MELISSA B | 2011 | Applied Geography2011，31，1： | 1 |
| 15 | Risk of lymphedema after mastectomy:potential benefit of applying ACOSOG Z0011protocol to mastectomy patients显示文摘 | Cynthia L M Michelle C S Melissa N S | 2014 | Breast Cancer Research and Treatment2014，144，1： | 1 |
| 16 | Interfirm Collabo- ration Networks: The impact of large- scale Network Structure on Firm Innovation 显示文摘 | Melissa A Schilling Corey C Phelps | 2007 | Management Science2007，，7： | 1 |
| 17 | Utility values and diabetic retinopathy显示文摘 | Melissa M Brown Gary C Brown Sanjay Sharma Gaurav Shah | 1999 | American Journal of Ophthalmology1999，，3： | 1 |
| 18 | Interfirmcollaboration networks: The impact of large - scale network structure on firm innovation 显示文摘 | Melissa A Schilling Corey C Phelps | 2007 | Management Science2007，53，7： | 1 |
| 19 | Anlimalarial activity of allicin, a biologically activc compound from garlic显示文摘 | Cloves A C Melissa C David M | 2006 | Anti micmb Agents Chemother2006，50，5： | 1 |
| 20 | Prevalence of suicidal idea- tion, attempts, and completed suicide rate in Chinese aging popula- tions: A systematic review显示文摘 | MELISSA S E-SHIE C PING Z | 2013 | Arch Gerontol Geriat2013，57，3： | 1 |
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