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| 1 | Personalizing therapies for gastric cancer: Molecular mechanisms and novel targeted therapies显示文摘Globally,gastric cancer is the 4thmost frequently diagnosed cancer and the 2ndleading cause of death from cancer,with an estimated 990000 new cases and738000 deaths registered in 2008.In the advanced setting,standard chemotherapies protocols acquired an important role since last decades in prolong survival.Moreover,recent advances in molecular therapies provided a new interesting weapon to treat advanced gastric cancer through anti-human epidermal growth factor receptor 2(HER2)therapies.Trastuzumab,an anti-HER2 monoclonal antibody,was the first target drug in the metastatic setting that showed benefit in overall survival when in association with platinum-5-fluorouracil based chemotherapy.Further,HER2 overexpression analysis acquired a main role in predict response for trastuzumab in this field.Thus,we conducted a review that will discuss the main points concerning trastuzumab and HER2 in gastric cancer,providing a comprehensive overview of molecular mechanisms and novel trials involved. | Michael Luis Ana Tavares Liliana S Carvalho Lúcio Lara-Santos António Araújo Ramon Andrade de Mello | 2013 | World Journal of Gastroenterology2013，19，38： | 6 |
| 2 | Anti-angiogenic therapies for metastatic colorectal cancer:Current and future perspectives显示文摘Colorectal cancer(CRC)is the fourth most commonly diagnosed cancer and the second leading cause of cancer death in both men and women in the United States,with about 142820 new cases and 50830 deaths expected in 2013.Metastatic disease(mCRC)remains a challenge for oncologists worldwide due to its potential comorbidities.Recently,chemotherapy regimens containing 5-fluorouracil,leucovorin,oxaliplatin and irinotecan combinations are a standard of care in the metastatic disease.Currently,biological therapies involving vascular endothelial growth factor and epidermal growth factor receptor pathways,such as bevacizumab and cetuximab,have emerged as good option for improving mCRC patient survival.Now,aflibercept plus standard chemotherapy has also been approved in second line regimen for mCRC patients.Our review will discuss novel biological drugs and their indications for mCRC patients and will bring future perspectives in this regard. | Inês Marques António Araújo Ramon Andrade de Mello | 2013 | World Journal of Gastroenterology2013，19，44： | 3 |
| 3 | A correct and complete algorithm for the generation of mechanical assembly sequences显示文摘 | Homem de Mello L S Sanderson A C | 1991 | IEEE Journal of Robotics and Automation1991，7，2： | 2 |
| 4 | Simultaneous Transfer Capability Assessment by Combining Imerior Point Methods and Monte Casrlo Simulation显示文摘 | Mello J C O Melo A C G Granville S | 1997 | IEEE Trans on Power Systems1997，12，2： | 1 |
| 5 | Unified Method for the Prediction of Rain Attenuation in Satellite and Terrestrial Links显示文摘 | DA SILVA MELLO L PONTES M S | 2012 | Journal of Microwaves Optoelectronics and Electromagnetic Applications2012，11，1： | 1 |
| 6 | The urokina olasminogen activator reeeor promotes efferocytosis of apoptotic celk显示文摘 | D'mello Vqingh S Wu Y | 2009 | J Biol Chem2009，284，17： | 1 |
| 7 | Effect of agaricus blaze imurill on the pulmonary tissue of animals with streptozoto cin-induced di- abetes 显示文摘 | Naso FC Mello RN Bona S | 2010 | Exp Diabetes Res2010，，2010： | 1 |
| 8 | Prediction of rain attenuation in terrestrial links using full rainfall rate distribution显示文摘 | SILLVA MELLO DA L A R PONTES M S SOUZA DE R M | 2007 | Electronics Letters2007，43，25： | 1 |
| 9 | A correct and complete algorithm for the generation of mechanical assembly sequences显示文摘 | SandersonAC | 1991 | IEEE Transation on Robotics and Automation1991，7，2： | 1 |
| 10 | A correct and complete algorithmfor the generation of mechanical assembly sequences显示文摘 | Homen de Mello L S Sanderson A | 1991 | IEEE Trans-action on Robotics and Automation1991，7，2： | 1 |
| 11 | Clinical evaluation of themicroscopic observation drug susceptibility assay for detection ofMycobacterium tuberculosis resistance to isoniazid or rifampin显示文摘 | Mello FC Arias MS Rosales S | 2007 | J Clin Microbiol2007，45，： | 1 |
| 12 | Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans显示文摘 | Fire A Xu S Montgomery M.K Kostas S.A Driver S.E and Mello C.C | | 0，，： | 1 |
| 13 | The effect of post-con- sumer PET particles on the performance of flexible poly- urethane foams 显示文摘 | de Mello D Pezzin S H | 2009 | Polymer Testing2009，28，7： | 1 |
| 14 | Lowtemperature epitaxial growth of CoGe2(001)/GaAs(100) films using the partially ionized显示文摘 | MELLO K E SOSS S R MURARKA S P | 1996 | Applied Physics Letters1996，68，13： | 1 |
| 15 | Detecting Naturalistic Expressions of Nonbasic Affect Using Physiological Signals 显示文摘 | ALZOUBI O D'MELLO S K CALVO R A | 2010 | IEEE Transactions on Affecitive Computing2010，1，2： | 1 |
| 16 | Scintillation mechanism of Tb3+doped Ba Y2F8显示文摘 | Ana C S de Mello Adriano B Andrade | 2010 | Optical Materials2010，32，： | 1 |
| 17 | Early postnatal maternal deprivation in rats induces memory deficits in adult life that can be reversed by donepezil and galantamine显示文摘 | Benetti F Mello P B Bonini J S | 2009 | Int J Dev Neurosci2009，27，1： | 1 |
| 18 | A correct and complete algorithm for the generation of mechanical assembly sequences显示文摘 | Homen de Mello L S Sanderson A C | 1991 | IEEE Transaction on Robotics and Automation1991，7，2： | 1 |
| 19 | Potent and specific genetic interference by double-stranded RNA in caenorhabditis elegans显示文摘 | Fire A Xu S Mello C C | 1998 | Nature1998，391，： | 1 |
| 20 | Affect detection:an interdiscipli- nary review of models,methods,and their applications显示文摘 | Calvo R A D Mello S | 2010 | IEEE Transactions on Affective Computing2010，1，1： | 1 |
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