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| 1 | Challenges in the diagnosis and treatment of gestational trophoblastic neoplasia worldwide显示文摘Gestational trophoblastic neoplasia(GTN) is a rare tumor that originates from pregnancy that includes invasive mole, choriocarcinoma(CCA), placental site trophoblastic tumor and epithelioid trophoblastic tumor(PSTT/ETT). GTN presents different degrees of proliferation, invasion and dissemination, but, if treated in reference centers, has high cure rates, even in multi-metastatic cases.The diagnosis of GTN following a hydatidiform molar pregnancy is made according to the International Federation of Gynecology and Obstetrics(FIGO)2000 criteria: four or more plateaued human chorionic gonadotropin(hCG)concentrations over three weeks; rise in hCG for three consecutive weekly measurements over at least a period of 2 weeks or more; and an elevated but falling hCG concentrations six or more months after molar evacuation. However,the latter reason for treatment is no longer used by many centers. In addition,GTN is diagnosed with a pathological diagnosis of CCA or PSTT/ETT. For staging after a molar pregnancy, FIGO recommends pelvic-transvaginal Doppler ultrasound and chest X-ray. In cases of pulmonary metastases with more than 1cm, the screening should be complemented with chest computed tomography and brain magnetic resonance image. Single agent chemotherapy, usually Methotrexate(MTX) or Actinomycin-D(Act-D), can cure about 70% of patients with FIGO/World Health Organization(WHO) prognosis risk score ≤ 6(low risk), reserving multiple agent chemotherapy, such as EMA/CO(Etoposide,MTX, Act-D, Cyclophosphamide and Oncovin) for cases with FIGO/WHO prognosis risk score ≥ 7(high risk) that is often metastatic. Best overall cure rates for low and high risk disease is close to 100% and > 95%, respectively. The management of PSTT/ETT differs and cure rates tend to be a bit lower. The early diagnosis of this disease and the appropriate treatment avoid maternal death,allow the healing and maintenance of the reproductive potential of these women. | Antonio Braga Paulo Mora Andréia Cristina de Melo Angélica Nogueira-Rodrigues Joffre Amim-Junior Jorge Rezende-Filho Michael J Seckl | 2019 | World Journal of Clinical Oncology2019，10，2： | 15 |
| 2 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 3 | Non-pharmacological management of pediatric functional abdominal pain disorders:Current evidence and future perspectives显示文摘Functional abdominal pain disorders(FAPDs) are an important and prevalent cause of functional gastrointestinal disorders among children, encompassing the diagnoses of functional dyspepsia, irritable bowel syndrome, abdominal migraine, and the one not previously present in Rome Ⅲ, functional abdominal pain not otherwise specified. In the absence of sufficiently effective and safe pharmacological treatments for this public problem, non-pharmacological therapies emerge as a viable means of treating these patients, avoiding not only possible side effects, but also unnecessary prescription, since many of the pharmacological treatments prescribed do not have good efficacy when compared to placebo. Thus, the present study provides a review of current and relevant evidence on non-pharmacological management of FAPDs, covering the most commonly indicated treatments, from cognitive behavioral therapy to meditation, acupuncture, yoga, massage, spinal manipulation, moxibustion, and physical activities. In addition, this article also analyzes the quality of publications in the area, assessing whether it is possible to state if non-pharmacological therapies are viable, safe, and sufficiently well-based for an appropriate and effective prescription of these treatments. Finally, it is possible to observe an increase not only in the number of publications on the non-pharmacological treatments for FAPDs in recent years, but also an increase in the quality of these publications. Finally, the sample selection of satisfactory age groups in these studies enables the formulation of specific guidelines for this age group, thus avoiding the need for adaptation of prescriptions initially made for adults, but for children use. | Maria Luísa Cordeiro Santos Ronaldo Teixeira da Silva Júnior Breno Bittencourt de Brito Filipe Antônio França da Silva Hanna Santos Marques Vinícius Lima de SouzaGonçalves Talita Costa dos Santos Carolina Ladeia Cirne Natália Oliveira e Silva Márcio Vasconcelos Oliveira Fabrício Freire de Melo | 2022 | World Journal of Clinical Pediatrics2022，11，2： | 2 |
| 4 | Role of myofibroblasts, macrophages, transforming growth factor-beta endothelin, angiotensin- Ⅱ , and fibronectin in the progression of tubulointerstitial nephritis induced by gentamicin 显示文摘 | Geleilete T J Melo G C Costa R S | 2002 | J Nephrol2002，15，6： | 1 |
| 5 | Simultaneous Transfer Capability Assessment by Combining Imerior Point Methods and Monte Casrlo Simulation显示文摘 | Mello J C O Melo A C G Granville S | 1997 | IEEE Trans on Power Systems1997，12，2： | 1 |
| 6 | Isolation and transplantation of autologous circulating endothelial cells into denuded vessels and prosthetic grafts: implica tions for cell based vascular therapy显示文摘 | Griese D P Ehsan A Melo L G Kong D Zhang L Mann M J | 2003 | Circulation2003，108，： | 1 |
| 7 | Clinical features and outcomes of 134 Brazilians with acute promyelocytic leukemia who received ATRA and anthracyclines显示文摘 | Jácomo R H Melo R A Souto F R | 2007 | Haematologica2007，92，10： | 1 |
| 8 | Assessing the applicabil- ity of fault-proneness models across object-oriented software projects显示文摘 | Briand L C Melo W L Wrist J | 2002 | IEEE Transactions on Software En- gineering2002，28，7： | 1 |
| 9 | The developing cancer stem-cell model: clinical challenges and opportunities显示文摘 | Louis Vermeulen Felipe de Sousa e Melo Dick J Richel Jan Paul Medema | 2012 | Lancet Oncology2012，，： | 1 |
| 10 | Phenol removal using Brassica juncea hairy roots: Role of inherent peroxidase and H2O2显示文摘 | Singh S Melo J S Eapen S | 2006 | J Biotechnol2006，123，1： | 1 |
| 11 | Hamack Inequality for a Class of Degenerate Elliptic Operator 显示文摘 | FERNANDES J D GROISMAN J MELO S T | 2003 | Zeitschrift fur Analysis Und Ihre Anwendungen2003，22，1： | 1 |
| 12 | Targeting the bcr-abl tyrosine kinase in chronic myeloid leukemia显示文摘 | GOLDMAN J M MELO J V | 2001 | N Engl J Med2001，344，14： | 1 |
| 13 | The diversity of BCR-ABL fusion proteins and their relationship to leukemia phenotype 显示文摘 | Melo J V | 1996 | Blood1996，88，7： | 1 |
| 14 | Adsorption of chromium (VI) ion from aqueous solution by succinylated mercerized cellulose functionalized with quaternary ammonium groups显示文摘 | Leandro Vinícius Alves Gurgel Júlio César Perin de Melo Jorge Carvalho de Lena Laurent Frédéric Gil | 2009 | Bioresource Technology2009，，13： | 1 |
| 15 | Tunable L-band Erbium-doped Fiber Ring Laser by Means of Induced Cavity Loss Using a Fiber Taper显示文摘 | Melo M FraZao O Teixeira A L J | 2003 | Appl Phys B2003，77，： | 1 |
| 16 | Isolation and characterization of soluble sulfated polysaccharide from the red seaweed Gracilaria cornea 显示文摘 | Melo M R S Feitosa J P A Freitas A L P | 2002 | Carbohydr Poly2002，49，： | 1 |
| 17 | 显示文摘 | Vidal J Vigil O de Melo O | 1999 | Materials Chemistry and Physics1999，61，： | 1 |
| 18 | Preparation of ethylenediamine-anchored cellulose and determination of thermochemical data for the interaction between cations and basic centers at the solid/liquid interface显示文摘 | da Silva Filho E C de Melo J C P Airoldi C | 2006 | Carbohydrate research2006，341，17： | 1 |
| 19 | Fundamental properties of flotation frothers and their effect on flotation显示文摘 | MELO F LASKWSKI J S | 2005 | Minerals Engineering2005，19，6： | 1 |
| 20 | A case study of air enrichment in rotary kiln incineration 显示文摘 | MELO G F CARVALHO J A | 1998 | International communications in heat and mass transfer1998，25，5： | 1 |
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