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| 1 | Bile-acid-activated farnesoid X receptor regulates hydrogen sulfide production and hepatic microcirculation显示文摘AIM: To investigate whether the farnesoid X receptor (FXR) regulates expression of liver cystathionase (CSE), a gene involved in hydrogen sulfi de (H2S) generation. METHODS: The regulation of CSE expression in response to FXR ligands was evaluated in HepG2 cells and in wild-type and FXR null mice treated with 6-ethyl chenodeoxycholic acid (6E-CDCA), a synthetic FXR ligand. The analysis demonstrated an FXR responsive element in the 5'-flanking region of the human CSE gene. The function of this site was investigated by luciferase reporter assays, chromatin immunoprecipitation and electrophoretic mobility shift assays. Livers obtained from rats treated with carbon tetrachloride alone, or in combination with 6-ethyl chenodeoxycholic acid, were studied for hydrogen sulphide generation and portal pressure measurement. RESULTS: Liver expression of CSE is regulated by bile acids by means of an FXR-mediated mechanism. Western blotting, qualitative and quantitative polymerase chain reaction, as well as immunohistochemical analysis, showed that expression of CSE in HepG2 cells and in mice is induced by treatment with an FXR ligand. Administration of 6E-CDCA to carbon tetrachloride treated rats protected against the down-regulation of CSE expression, increased H2S generation, reduced portal pressure and attenuated the endothelial dysfunction of isolated and perfused cirrhotic rat livers. CONCLUSION: These results demonstrate that CSE is an FXR-regulated gene and provide a new molecular explanation for the pathophysiology of portal hypertension. | Barbara Renga Andrea Mencarelli Marco Migliorati Eleonora Distrutti Stefano Fiorucci | 2009 | World Journal of Gastroenterology2009，15，17： | 7 |
| 2 | The third gas:H2S regulates perfusion pressure in both the isolated and perfused normal rat liver and in cirrhosis显示文摘 | Fiorucci S Antonelli E Mencarelli A | 2005 | Hepatology2005，42，3： | 1 |
| 3 | Gastrointestinal stromal tumors: from a surgical to a molecular approach 显示文摘 | Rossi CR Mocellin S Mencarelli R | 2003 | Int J Cancer2003，107，2： | 1 |
| 4 | The methionine connection:homocysteine and hydrogen sulfide exert opposite effects on hepatic microcirculation in rats显示文摘 | Distrutti E Mencarelli A Santucci L | 2008 | Hepatology2008，47，2： | 1 |
| 5 | Gastrointestinal stromal tumors: from a surgical to a molecular approach 显示文摘 | Rossi CR Mocellin S Mencarelli R | 2003 | Int J Cancer2003，107，2： | 1 |
| 6 | The third gas : H2 S regu- lates perfusion pressure in both the isolated and perfused normal rat liver and in cirrhosis显示文摘 | Fiorucci S Antonelli E Mencarelli A | 2005 | Hepatology2005，42，3： | 1 |
| 7 | The farnesoid X-receptor is an essential regulator of cholesterol homeostasis显示文摘 | Fiorucci S Mencarelli A Distrutti E Zampella A | | 0，，： | 1 |
| 8 | Feasibility of an electronic nose to differentiate commercial Spanish wines elaborated from the same grape variety显示文摘 | María de las Nieves López de Lerma Andrea Bellincontro Teresa García-Martínez Fabio Mencarelli Juan José Moreno | 2013 | Food Research International2013，，2： | 1 |
| 9 | Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in chole-stasis显示文摘 | Renga B Mencarelli A D'Amore C | 2012 | PLoS One2012，7，30： | 1 |
| 10 | The third gas: H2S regulates perfusion pressure in both the isolated and perfusednormal rat liver and in cirrhosis 显示文摘 | Fiorucci S Antonelli E Mencarelli A | 2005 | Hepatology2005，42，3： | 1 |
| 11 | The third gas:H2S regulates perfusion pressure in both the isolated and perfused normal rat liver and in cirrhosis显示文摘 | Fiorucci S Antonelli E Mencarelli A | 2005 | Hepatology2005，42，3： | 1 |
| 12 | Dynamic mechanical thermal analysis of hypromellose 2910 free films显示文摘 | CESPI M BONACUCINA G MENCARELLI G | 2011 | European Journal of Pbarmaeeutics and Biopharmaeeuties2011，79，2： | 1 |
| 13 | The bile acid receptor FXR is a modulator of intestinal innate immunity 显示文摘 | Vavassori P Mencarelli A Renga B | 2009 | J Immunol2009，183，： | 1 |
| 14 | The bile acid receptor GPBAR-1(TGR5)modulates integrity of intestinal barrier and immune response to experimental colitis显示文摘 | Cipriani S Mencarelli A Chini M G | 2011 | PLo S One2011，6，25： | 1 |
| 15 | The bile acid receptor FXR is a modulator of intestinal innate im- munity显示文摘 | VAVASSORI P MENCARELLI A RENGA B eta | 2009 | J Immunol2009，183，10： | 1 |
| 16 | Gastrointestinal stromal tumors: from a surgical to a molecular approach 显示文摘 | Rossi CR Mocellin S Mencarelli R | 2003 | Int J Cancer2003，107，2： | 1 |
| 17 | 1-MCP controls ripening induced by impact injury on apricots by affecting SOD and POX activities 显示文摘 | De Martino G Vizovitis K Botondi R Bellincontro A Mencarelli F | 2006 | Postharvest Biology and Technology2006，39，： | 1 |
| 18 | Farnesoid X receptor:From medicinal chemistry to clinical applica- tions显示文摘 | Fiorucei S Mencarelli A Distrutti E | 2012 | Future Med Chem2012，4，7： | 1 |
| 19 | The third gas: H2S regulates perfusion pressure in both the isolated and perfused normal rat liver and in cirrhosis 显示文摘 | Fiorueei S Antonelli E Mencarelli A | 2005 | Hepatology2005，42，3： | 1 |
| 20 | The tbird gas: H2 S regulates perfusion pressure in both the isolated and per- fused normal rat liver and in cirrhosis显示文摘 | FIORUCEI S ANTONELLI E MENCARELLI A | 2005 | Hepatology2005，42，3： | 1 |
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