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| 1 | Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice显示文摘AIM To investigate the effect of probiotic supplementation during the development of an experimental model of colitis associated colon cancer(CAC). METHODS C57 BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg), followed by three cycles of sodium dextran sulphate diluted in water(5% w/v). Probiotic group received daily a mixture of Lactobacillus acidophilus, Lactobacil us rhamnosus and Bifidobacterium bifidum. Microbiota composition was assessed by 16 Sr RNA Illumina Hi Seq sequencing. Colon samples were collected for histological analysis. Tumor cytokines was assessed by Real Time-PCR(Polymerase Chain Reaction); and serum cytokines by Multiplex assay. All tests were two-sided. The level of significance was set at P < 0.05. Graphs were generated and statistical analysis performed using the software Graph Pad Prism 5.0. The project was approved by the institutional review board committee. RESULTS At day 60 after azoxymethane injection, the mean number of tumours in the probiotic group was 40% lower than that in the control group, and the probiotic group exhibited tumours of smaller size(< 2 mm)(P < 0.05). There was no difference in richness and diversity between groups. However, there was a significant difference in beta diversity in the multidimensional scaling analysis. The abundance of the genera Lactobacillus, Bifidobacterium, Allobaculum, Clostridium XI and Clostridium XVⅢ increased in the probiotic group(P < 0.05). The microbial change was accompanied by reduced colitis, demonstrated by a 46% reduction in the colon inflammatory index; reduced expression of the serum chemokines RANTES and Eotaxin; decreased p-IKK and TNF-α and increased IL-10 expression in the colon. CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on CAC. Probiotic supplementation changes microbiota structure and regulates the inflammatory response, reducing colitis and preventing CAC. | Maria Carolina S Mendes Daiane SM Paulino Sandra R Brambilla Juliana A Camargo Gabriela F Persinoti José Barreto C Carvalheira | 2018 | World Journal of Gastroenterology2018，24，18： | 17 |
| 2 | The role of constraints within generalized nonextensive statistics显示文摘 | Tsallis C Mendes R S Plastino A R | 1998 | Physica A:Statistical Mechanics and its Applications1998，261，3： | 1 |
| 3 | One dimensional model of phase holdups in three phase stratified flow显示文摘 | Khor S H Mendes Tatsis M A Hewitt G F | 1997 | Int J Muhiphase Flow1997，23，5： | 1 |
| 4 | Ectopic micronodular thymoma with lymphoid stroma显示文摘 | Mende S Moschopulos M Marx A | 2004 | Virchows Arch2004，444，4： | 1 |
| 5 | Structure of growing networks with preferential linking显示文摘 | Dorogovtsev S N Mendes J F F Samukhin A N | 2000 | Phys Rev Lett2000，85，21： | 1 |
| 6 | Effects of the glyphosate-resistance gene and herbicides on soybean: Field trials monitoring biological nitrogen fixation and yield显示文摘 | Hungria M Mendes I C Nakatani A S | 2014 | Field Crops Research2014，158，： | 1 |
| 7 | Pseudofractal scale-free web显示文摘 | DOROGOVTSEV S N GOLTSEV A V MENDES J F F | 2002 | Phys Rev E2002，65，： | 1 |
| 8 | Structure of growing networks with preferential linking显示文摘 | DOROGOVTSEV S N MENDES J F F SAMUKHIN A N | 2000 | Physica Review Lett2000，85，： | 1 |
| 9 | Aging study of carbon molecular sieve membranes显示文摘 | Lagorsse S Magalhdes F D Mendes A | 2008 | J Membr Sei2008，310，12： | 1 |
| 10 | How to generate a random growing network显示文摘 | Dorogovtsev S N Mendes J F F Samukhin A N | 2002 | arXiv:cond-mat/02061322002，，： | 1 |
| 11 | Analysis of torsional vibration in internal combustion engines:modeling and experimental validation显示文摘 | MENDES A MEIRELLES P S ZAMPIERI D E | 2008 | Proceedings of the Institution of Mechanical Engineers Part K:Journal of Multi-body Dynamics2008，222，： | 1 |
| 12 | Structure of growing networks with preferential linking 显示文摘 | Dorogovtsev S N Mendes J F F Samukhin A N | 2000 | Physical Re- view Letters2000，85，2： | 1 |
| 13 | Structure of Growing Networks with Preferential Linking显示文摘 | S N Dorogovtsev J F F Mendes A N Samukhin | 2000 | Phys Rev Lett2000，85，： | 1 |
| 14 | Incidence and risk factors of major toxicity associated to firstline antituberculosis drugs for latent and active tuberculosis during a period of 10 years 显示文摘 | CASTRO A T MENDES M FREITAS S | 2015 | Rev Port Pneumol2015，21，3： | 1 |
| 15 | Structure of Growing Networks with Preferential Linking显示文摘 | Dorogovtsev S N Mendes J F F Samukhin A N | 2000 | Physical Review Letters2000，85，21： | 1 |
| 16 | Influence of dietary lysine levels and arginme:lysine tat los on performance of broilers exposed to heat or cold stree during the period of three to six weeks of age 显示文摘 | Mendes A A Watkins S E England J A | 1997 | Poultry Sci1997，76，3： | 1 |
| 17 | Comparative bronchial vasoconstrictive efficacy of inhaled glucocorticosteroids显示文摘 | Mendes E S Pereira A Danta I | 2003 | Eur Respir J2003，21，6： | 1 |
| 18 | Structure of growing networks:Exact solution of the Barabasi-Albert model显示文摘 | Dorogovtsev S N Mendes J F F Samukhin A N | 2000 | Physical Review Letter2000，85，： | 1 |
| 19 | Coin- paralive bronchial vasoconstrictive efficacy of inhaled glucocorticosteroids 显示文摘 | Mendes E S Pereira A Danta 1 | 2004 | Eur Respir J2004，21，6： | 1 |
| 20 | Structure of growing networks with preferential linking 显示文摘 | Dorogovtsev S N Mendes J F F Samukhin A N | 2002 | Physical Review Letters2002，85，21： | 1 |
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