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| 1 | Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn’s disease patients显示文摘AIM:To investigate the interaction of interleukin-23 receptor(IL23R)(rs1004819 and rs2201841),autophagy-related 16-like 1(ATG16L1)(rs2241880), caspase recruitment domain-containing protein 15 (CARD15)genes,and IBD5 locus in Crohn's disease(CD) patients. METHODS:A total of 315 unrelated subjects with CD and 314 healthy controls were genotyped.Interactions and specific genotype combinations of a total of eight variants were tested.The variants of IBD5locus(IGR2198a_1 rs11739135 and IGR2096a_1 rs12521868),CARD15(R702W rs2066845 and L1007fs rs2066847),ATG16L1(rs2241880)and IL23R (rs1004819,rs2201841)genes were genotyped by PCR-RFLP,the G908R(rs2066844)in CARD15 was determined by direct sequencing. RESULTS:The association of ATG16L1 T300A with CD was confirmed[P=0.004,odds ratio(OR)=1.69, 95%CI:1.19-2.41],and both IL23R variants were found to represent significant risk for the disease(P= 0.008,OR=2.05,95%CI:1.20-3.50 for rs1004819 AA;P<0.001,OR=2.97,95%CI:1.65-5.33 for rs2201841 CC).Logistic regression analysis of pairwise interaction of the inflammatory bowel disease (IBD)loci indicated that IL23R,ATG16L1,CARD15 and IBD5(IGR2198a_1)contribute independently to disease risk.We also analysed the specific combina- tions by pair of individual ATG16L1,IL23R rs1004819, rs2201841,IGR2198a_1,IGR2096a_1 and CARD15 genotypes for disease risk influence.In almost all cases,the combined risk of susceptibility pairs was higher in patients carrying two different risk-associated gene variants together than individuals with just one polymorphism.The highest OR was found for IL23R rs2201841 homozygous genotype with combination of positive CARD15 status(P<0.001,OR=9.15,95% CI:2.05-40.74). CONCLUSION:The present study suggests a cumulative effect of individual IBD susceptibility loci. | Veronika Csngei Luca Járomi EnikSáfrány Csilla Sipeky Lili Magyari Bernadett Faragó Judit Bene Noémi Polgár Lilla Lakner Patrícia Sarlós Márta Varga Béla Melegh | 2010 | World Journal of Gastroenterology2010，16，2： | 2 |
| 2 | New filtration process cuts contaminants from offshore produced water 显示文摘 | Mi S A Henry L R Darlington J W | 1998 | Oil and Gas Journal1998，96，44： | 1 |
| 3 | Incorporating a statistically based shape model into a system for computor-assisted anterior cruciate ligament surgery显示文摘 | Markus F St(e)phane L R(e)mi J | 1999 | Medical Image Analysis1999，3，3： | 1 |
| 4 | Phenotypic characterization of idiosyncratic drug-induced liver injury: the influence of age and sex显示文摘 | Lucena MI Andrade R J Kaplowitz N | 2009 | Hepatology2009，49，： | 1 |
| 5 | Immortalized neural stem cells differ from nonimmortalized cortical neurospheres and cerebellar granule ceil progenitors显示文摘 | Mi R Luo Y Cai J | 2005 | Exp Neurol2005，194，2： | 1 |
| 6 | A numerical simulation of gas flow field effects on high pressure gas atomization due to operating pressure variation 显示文摘 | MI J FIGLIOLA R S ANDERSON I E | 1996 | Mater Sci Eng A1996，208，： | 1 |
| 7 | Autoimmunity inflammation from theTh17perspective显示文摘 | FURUZAWA-CARBALLEDA J VARGAS-ROJAS MI CABRAL A R | 2007 | Autoimmun Rev2007，6，： | 1 |
| 8 | A numerical investigation of gas flow effects on high-pressure gas atomization due to melt tip geometry variation 显示文摘 | MI J FIGLIOLA R S ANDERSON I E | 1997 | Metallurgical and Materials Transactions B1997，28，： | 1 |
| 9 | Therapeutic induction of arteriogenesis in hypoperfused rat brain via granulocyte2 macrophage colony2 stimulating factor显示文摘 | Buschman I R Busch H J Mies G | 2003 | Circulation2003，108，5： | 1 |
| 10 | High-performance liquid chromatographic determination of vancomycin in rabbit senlm, vitreous and aqueous humour after intravitreal injection of the drug显示文摘 | DelNozal M J Bemal JL Pampliega A Marinero P Lopez MI Coco R | 1996 | J Chromatogr A1996，727，2： | 1 |
| 11 | Hall Characterization of the class 3 integron and the site-specific recombination system it determines显示文摘 | Collis C M Kim Mi J Sally R | 2002 | Bacteriol2002，184，11： | 1 |
| 12 | MiRNAs and Their Association with Locoregional Staging and Survival Following Surgery for Esophageal Carcinoma显示文摘 | Hummel R Hussey D J et al Michael MI | | 0，，01： | 1 |
| 13 | The role of oxygenderived free radicals in ischemia-induced increases in canine skeletal muscle vascular permeability显示文摘 | Korthuis R J Granger DN Townsley MI | 1985 | Cite Res1985，57，4： | 1 |
| 14 | Tumor Necrosis Factor a and toxicology显示文摘 | Luster MI Simeonova PP Gallucci R Matheson J | 1999 | Crit Rev Toxicol1999，29，： | 1 |
| 15 | Mouse eye gene microarrays for investigating ocular development and disease显示文摘 | Farjo R Yu J Othman MI | | 0，，： | 1 |
| 16 | Pharmacological therapy for idiopathic pulmonary fibrosis :past ,present ,and future 显示文摘 | Mason R J Schwartz MI Hunninghake GW | 1999 | Am J Respir Crit Care Med1999，160，5： | 1 |
| 17 | Novel KPC Variant from a Carbapenem-Resistant Strain of Klebsiella pneumoniae in a Chinese Hospital显示文摘 | Zhu JM Jiang R J MI ZH | 2011 | Infect Control Hosp Epidemiol2011，32，10： | 1 |
| 18 | Estrogen-dependent and estrogen-independent mechanisms contribute to AIB1- mediated tumor formation 显示文摘 | Torres-Arzayus MI Zhao J Bronson R | 2010 | Cancer Res2010，70，10： | 1 |
| 19 | Prognostic significance of 2-hydroxyglutarate levels in acute myeloid leukemia in China显示文摘 | Wang J H Chen W L Li J M Wu S F Chen T L Zhu Y M Zhang W N Li Y Qiu Y P Zhao A H Mi J Q Jie J Wang Y G Ma Q L Huang H Wu D P Wang Q R Li Y Yan X J Yan J S Li J Y Wang S Huang X J Wang B S Jia W Shen Y Chen Z Chen S J | 2013 | Proceedings of the National Academy of Sciences2013，110，17： | 1 |
| 20 | Immortalized neural stem cells differ from nonimmortalized cortical neurospheres and cerebellar granule cell progenitors显示文摘 | Mi R Luo Y Cai J | 2005 | Exp Neurol2005，194，： | 1 |
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