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| 1 | Frequency and prognostic role of mucosal healing in patients with Crohn's disease and ulcerative colitis after one-year of biological therapy显示文摘AIM:To assess the endoscopic activity before and after a one-year period of biological therapy and to evaluate the frequency of relapses and need for retreatment after stopping the biologicals in patients with Crohn’s disease(CD)and ulcerative colitis(UC).METHODS:The data from 41 patients with CD and 22 patients with UC were assessed.Twenty-four CD patients received infliximab,and 17 received adalimumab.The endoscopic severity of CD was quantified with the simplified endoscopic activity score for Crohn’s disease in CD and with the Mayo endoscopic subscore in UC.RESULTS:Mucosal healing was achieved in 23 CD and7 UC patients.Biological therapy had to be restarted in78%of patients achieving complete mucosal healing with CD and in 100%of patients with UC.Neither clinical remission nor mucosal healing was associated with the time to restarting the biological therapy in either CD or UC.CONCLUSION:Mucosal healing did not predict sustained clinical remission in patients in whom the biological therapies had been stopped. | Klaudia Farkas Péter László Lakatos Mónika Szcs va Pallagi-Kunstár Anita Bálint Ferenc Nagy Zoltán Szepes Noémi Vass Lajos S Kiss Tibor Wittmann Tamás Molnár | 2014 | World Journal of Gastroenterology2014，20，11： | 2 |
| 2 | 循环脂肪因子与超声心动图测量的心脏结构和功能的关系:基于社区的队列研究显示文摘脂肪因子介导与肥胖相关的心脏代谢风险,但它们在肥胖相关心力衰竭的发病机制中的作用仍然不确定。von Jeinsen等调查了社区样本中循环脂肪因子浓度与超声心动图测量的心功能和结构指标之间的关联。研究纳入3514名Framingham心脏研究参与者(平均年龄40岁,53.8%为女性). | 刘莉 叶鹏 von Jeinsen B Short MI Xanthakis V Carneiro H Cheng S Mitchell GF Vasan RS | 2018 | 中华高血压杂志2018，26，8： | 2 |
| 3 | Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn’s disease patients显示文摘AIM:To investigate the interaction of interleukin-23 receptor(IL23R)(rs1004819 and rs2201841),autophagy-related 16-like 1(ATG16L1)(rs2241880), caspase recruitment domain-containing protein 15 (CARD15)genes,and IBD5 locus in Crohn's disease(CD) patients. METHODS:A total of 315 unrelated subjects with CD and 314 healthy controls were genotyped.Interactions and specific genotype combinations of a total of eight variants were tested.The variants of IBD5locus(IGR2198a_1 rs11739135 and IGR2096a_1 rs12521868),CARD15(R702W rs2066845 and L1007fs rs2066847),ATG16L1(rs2241880)and IL23R (rs1004819,rs2201841)genes were genotyped by PCR-RFLP,the G908R(rs2066844)in CARD15 was determined by direct sequencing. RESULTS:The association of ATG16L1 T300A with CD was confirmed[P=0.004,odds ratio(OR)=1.69, 95%CI:1.19-2.41],and both IL23R variants were found to represent significant risk for the disease(P= 0.008,OR=2.05,95%CI:1.20-3.50 for rs1004819 AA;P<0.001,OR=2.97,95%CI:1.65-5.33 for rs2201841 CC).Logistic regression analysis of pairwise interaction of the inflammatory bowel disease (IBD)loci indicated that IL23R,ATG16L1,CARD15 and IBD5(IGR2198a_1)contribute independently to disease risk.We also analysed the specific combina- tions by pair of individual ATG16L1,IL23R rs1004819, rs2201841,IGR2198a_1,IGR2096a_1 and CARD15 genotypes for disease risk influence.In almost all cases,the combined risk of susceptibility pairs was higher in patients carrying two different risk-associated gene variants together than individuals with just one polymorphism.The highest OR was found for IL23R rs2201841 homozygous genotype with combination of positive CARD15 status(P<0.001,OR=9.15,95% CI:2.05-40.74). CONCLUSION:The present study suggests a cumulative effect of individual IBD susceptibility loci. | Veronika Csngei Luca Járomi EnikSáfrány Csilla Sipeky Lili Magyari Bernadett Faragó Judit Bene Noémi Polgár Lilla Lakner Patrícia Sarlós Márta Varga Béla Melegh | 2010 | World Journal of Gastroenterology2010，16，2： | 2 |
| 4 | Worldwide time trends in the prevalence of symptoms of asthma, allergic rhino- conjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys 显示文摘 | Asher MI Montefort S Bjorksten B | 2006 | Lancet2006，368，： | 1 |
| 5 | LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG- induced experimental autoimmune encephalomyelitis 显示文摘 | Mi S Hu B Hahm K | 2007 | Nat Med2007，13，10： | 1 |
| 6 | Asymmetric chitosan membranes prepared by dry/wet phase separation:a new type of wound dressing for controlled antibacterial release显示文摘 | Mi F L Wu Y B Shyu S S | 2003 | J Memb Sci2003，212，12： | 1 |
| 7 | New polytypes of long-period stacking or- dered structures in Mg-Co-Y alloys 显示文摘 | Mi S B Jin Q Q | 2013 | Scripta Materialia2013，68，8： | 1 |
| 8 | Multi-scale fractal dimension based on morphological covering for gear fault diagnosis显示文摘 | LI B ZHANG P L MI S S | 2011 | Journal of Mechanical Engineering2011，225，9： | 1 |
| 9 | Serum paraoxonase(PON1) 55 and 192 polymorphism and paraoxonase activity and concentration in non-insulin dependent diabetes mellitus显示文摘 | Mackness B Mackness MI Arrol S | 1998 | Atherosclerosis1998，139，： | 1 |
| 10 | Fabrication and characterization of a sponge-like asymmetric chitosan membrane as a wound dressing显示文摘 | L Mi S S Shyu Y B Wu S T Lee | 2001 | Biomaterials2001，22，： | 1 |
| 11 | Effect of the human serum paraoxonase 55 and 192 genetic polymorphisms on the protection by high density lipoprotein against low density lipoprotein oxidative modification 显示文摘 | Mackness B Mackness MI Arrol S | 1998 | FEBS Lett1998，423，： | 1 |
| 12 | In Situ synthesis and properties of carbon-coated LiFePO4 as Li-ion battery cathodes显示文摘 | Mi C H Zhao X B Cao G S | 2005 | J Electrochem Soc2005，152，3： | 1 |
| 13 | Inhibition of in vivo tumor angiogenesis and growth via systemic delivery of an angiopoietin 2-specific RNA aptamer显示文摘 | Sarraf-Yazdi S Mi J Moeller B J | 2008 | J Surg Res2008，146，1： | 1 |
| 14 | Effect of home mechanical ventilation on inspiratory muscle strength in COPD 显示文摘 | Schnhofer B Polkey MI Suchi S | 2006 | Chest2006，130，6： | 1 |
| 15 | Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISASC Phases One and Three repeat multi- country cross-sectinal surveys显示文摘 | Asher MI Montefort S Bjorksten B | 2006 | Lancet2006，368，9537： | 1 |
| 16 | Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional sutweys显示文摘 | Asher MI Montefort S Bjorkston B | 2006 | Lancet2006，368，9537： | 1 |
| 17 | Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multieountry cross - sectional surveys 显示文摘 | Asher MI Montefort S Bjorkston B | 2006 | Lancet2006，368，9537： | 1 |
| 18 | Review of fabrication tech- niques for fused fiber components for fiber lasers显示文摘 | WANG B S MIES E | 2009 | SPIE2009，7195，： | 1 |
| 19 | Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases one and three repeat muhicountry crosssectional surveys 显示文摘 | Asher MI Montefort S Bjorksten B | 2006 | Lancet2006，368，9537： | 1 |
| 20 | Presence of paraoxonase in human interstitial fluid显示文摘 | Mackness MI Mackness B Arrol S | 1997 | FEBS Lett1997，416，3： | 1 |
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