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| 1 | SMARCE1 suppresses EGFR expression and controls responses to MET and ALK inhibitors in lung cancer显示文摘 | Andreas I Papadakis Chong Sun Theo A Knijnenburg Yibo Xue Wipawadee Gremrum Michael Holzel Wouter Nijkamp Lodewyk FA Wessels Roderick L Beijersbergen Rene Bernards Sidong Huang | 2015 | Cell Research2015，25，4： | 4 |
| 2 | Comparative effectiveness of i-SCAN^(TM) and high-definition white light characterizing small colonic polyps显示文摘AIM:To evaluate accuracy of in vivo diagnosis of adenomatous vs non-adenomatous polyps using i-SCAN digital chromoendoscopy compared with high-definition white light.METHODS:This is a single-center comparative effectiveness pilot study.Polyps(n = 103) from 75 averagerisk adult outpatients undergoing screening or surveillance colonoscopy between December 1,2010 and April 1,2011 were evaluated by two participating endoscopists in an academic outpatient endoscopy center.Polyps were evaluated both with high-definition white light and with i-SCAN to make an in vivo prediction of adenomatous vs non-adenomatous pathology.We determined diagnostic characteristics of i-SCAN and highdefinition white light,including sensitivity,specificity,and accuracy,with regards to identifying adenomatous vs non-adenomatous polyps.Histopathologic diagnosis was the gold standard comparison.RESULTS:One hundred and three small polyps,detected from forty-three patients,were included in the analysis.The average size of the polyps evaluated in the analysis was 3.7 mm(SD 1.3 mm,range 2 mm to 8 mm).Formal histopathology revealed that 54/103(52.4%) were adenomas,26/103(25.2%) were hyperplastic,and 23/103(22.3%) were other diagnoses include 'lymphoid aggregates','non-specific colitis,' and 'no pathologic diagnosis.' Overall,the combined accuracy of endoscopists for predicting adenomas was identical between i-SCAN(71.8%,95%CI:62.1%-80.3%) and high-definition white light(71.8%,95%CI:62.1%-80.3%).However,the accuracy of each endoscopist differed substantially,where endoscopist A demonstrated 63.0% overall accuracy(95%CI:50.9%-74.0%) as compared with endoscopist B demonstrating 93.3% overall accuracy(95%CI:77.9%-99.2%),irrespective of imaging modality.Neither endoscopist demonstrated a significant learning effect with i-SCAN during the study.Though endoscopist A increased accuracy using i-SCAN from 59%(95%CI:42.1%-74.4%) in the first half to 67.6%(95%CI:49.5%-82.6%) in the second half,and endoscopist B decreased accuracy using i-SCAN from 100%(95%CI:80.5%-100.0%) in the first half to 84.6%(95%CI:54.6%-98.1%) in the second half,neither of these differences were statistically significant.CONCLUSION:i-SCAN and high-definition white light had similar efficacy predicting polyp histology.Endoscopist training likely plays a critical role in diagnostic test characteristics and deserves further study. | Johanna L Chan Li Lin Michael Feiler Andrew I Wolf Diana M Cardona Ziad F Gellad | 2012 | World Journal of Gastroenterology2012，18，41： | 3 |
| 3 | Sperm counts and sperm sex ratio in male infertility patients显示文摘在最近的年里,调查者在许多工业化国家向男出生的一个衰退比例注意了一个趋势。当人们忍受决定性的染色体时,它与授精或流产相关的女搭挡的角色可以也改变性比率。我们试图由直接检验他的精子的性染色体决定一个人的第二等的性比率(F1 产生) 。我们为在 situ 杂交(鱼) 经历了精液荧光的所有人检验了我们的男不孕诊所数据库。人口统计的病人和精液参数被记录。摆平 Chi 的分析被用来比较性比率(Y 染色体 / 总数染色体) 。Multivariable 逻辑回归被用来预言在财务以后拥有一个忍受 Y 精子为的机会人口统计并且精液参数。185 个人的一个总数经历了精子鱼。为全部队, Y 忍受染色体的精子的比例是 51.5 %。有不到 500 万个能动精子的人有 Y 忍受染色体的精子的一个显著地更低的比例(50.8 %) 与有更高的精子计数的人相比(51.6 %P=0.02 ) 。在 multivariable 调整以后,更高的精子集中,全部的能动精子计数和精液体积显著地增加了有 Y 的机会忍受染色体的精子(P< 0.01 ) 。作为一个人的精子生产衰落,那么做 Y 忍受染色体的精子的比例。因此,一个人的繁殖潜力可以预言他的能力到陛下男性后代。 | Michael L Eisenberg Lata Murthy Kathleen Hwang Dolores J Lamb Larry I Lipshultz | 2012 | Asian Journal of Andrology2012，14，5： | 3 |
| 4 | Pentoxifylline treatment and penile calcifications in men Nith Peyronie's disease显示文摘 | James F Smith Alan W Shindel Yun-Ching Huang Raul I Clavijo Lawrence Flechner Benjamin N Breyer Michael L Eisenberg Tom F Lue | 2011 | Asian Journal of Andrology2011，13，2： | 2 |
| 5 | HIPI and HIPlr stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains显示文摘 | Hyun T S Rao D S Saint-Dic D Michael L E Kumar P D Bradley S V Mizukami I F | | 0，，14： | 1 |
| 6 | Spontaneous network formation among cooperative RNA replicators显示文摘 | VAIDYA N MICHAEL M L CHEN I A | 2012 | Nature2012，，491： | 1 |
| 7 | Ob- structive sleep apnea is associated with increased urinary albumin excertion显示文摘 | MICHAEL D F AMY S I KIRCHNER H L | 2007 | Sleep2007，30，7： | 1 |
| 8 | Serum VEGF levels and tissue aetivation of VEGFR2/KDR reeeptors in patients with breast and gynecologic eaneer显示文摘 | Michael I Koukourakis Vassilios L | 2011 | Cytokine2011，53，3： | 1 |
| 9 | Gene expression analysis of toll - like receptor path- ways in heterophils from genetic chicken lines that dif- fer in their susceptibility to salmonella enteritidis 显示文摘 | MICHAEL H K HSIN I C CHRISTINA L S | 2012 | Front Genet2012，3，： | 1 |
| 10 | 0-Defensins: cyclic pep- tides with endless potential显示文摘 | Robert I L Alex M C Michael E S | 2012 | J Biol Chem2012，287，27： | 1 |
| 11 | The mechanism of catalysis and the inhibition of 13 -lactamases 显示文摘 | MichaeL I Andrew P L | 1998 | Chem Commun1998，，： | 1 |
| 12 | Position of the American Dietetic Association:Health implication of dietary fiber显示文摘 | Michael I McBurney Joanne L Slayin | 2002 | Journal of the American Dietetic Association2002，102，7： | 1 |
| 13 | Using the chlorite ion tocontrol nitrification显示文摘 | MICHAEL J M NANCY I L MARIE S P | 1999 | American Water Works Association Journal1999，91，10： | 1 |
| 14 | Exploitation, exploration, and process management: The productivity dilemma revisited显示文摘 | Benner Mary I and Tushman Michael L | 2003 | Academy of Management Review2003，28，2： | 1 |
| 15 | Urban wastewater treatment plants as hotspots for the release of antibiotics in the environment:A review显示文摘 | MICHAEL I RIZZO L MCARDELL C S | 2013 | Water research2013，47，3： | 1 |
| 16 | Toxicity of chloroform and carbon tetrachloride in primary cultures of rainbow trout hepatocytes显示文摘 | Christina M I Michael M L | 1997 | Aquatic Toxicology1997，37，： | 1 |
| 17 | Urban wastewater treat- ment plants as hotspots for the release of antibiotics in the environ- ment: A review显示文摘 | Michael I Rizzo L McArdell CS | 2013 | Water Res2013，47，3： | 1 |
| 18 | Adominal adhesions to Prosthetic mesh evaluated by laparoscnpy and electron microscopy 显示文摘 | Michael L Delaney J P Felemovicius I | 2000 | JAm CollSurg2000，190，3： | 1 |
| 19 | Urban wastewater treatment plants as hotspots for the release of antibiotics in the environment: a review显示文摘 | Michael I Rizzo L McArdell C S | 2013 | Water Research2013，7，3： | 1 |
| 20 | The inhibition of the adhesion of clinically isolated bacte-rial strains on multi-component cross-linked poly (ethylene glycol)-based polymer coatings显示文摘 | Saldarriaga F I C Henny C van der Mei Michael J L | 2007 | Biomaterials2007，28，28： | 1 |
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