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| 1 | Diagnostic accuracy of endoscopic ultrasound in pancreatic neuroendocrine tumors: A systematic review and meta analysis显示文摘AIM: To detect pancreatic neuroendocrine tumors (PNETs) has been varied. This study is undertaken to evaluate the accuracy of endoscopic ultrasound (EUS) in detecting PNETs.METHODS: Only EUS studies confirmed by surgery or appropriate follow-up were selected. Articles were searched in Medline, Ovid journals, Medline nonindexed citations, and Cochrane Central Register of Controlled Trials and Database of Systematic Reviews. Pooling was conducted by both fixed and random effects model). RESULTS: Initial search identified 2610 reference articles, of these 140 relevant articles were selected and reviewed. Data was extracted from 13 studies (n = 456) which met the inclusion criteria. Pooled sensitivity of EUS in detecting a PNETs was 87.2% (95%CI: 82.2-91.2). EUS had a pooled specificity of 98.0% (95%CI: 94.3-99.6). The positive likelihood ratio of EUS was 11.1 (95%CI: 5.34-22.8) and negative likelihood ratio was 0.17 (95%CI: 0.13-0.24). The diagnostic odds ratio, the odds of having anatomic PNETs in positive as compared to negative EUS studies was 94.7 (95%CI: 37.9-236.1). Begg-Mazumdar bias indicator for publication bias gave a Kendall's tau value of 0.31 (P = 0.16), indication no publication bias. The P for χ2 heterogeneity for all the pooled accuracy estimates was > 0.10. CONCLUSION: EUS has excellent sensitivity and specificity to detect PNETs. EUS should be strongly considered for evaluation of PNETs. | Srinivas R Puli Nikhil Kalva Matthew L Bechtold Smitha R Pamulaparthy Micheal D Cashman Norman C Estes Richard H Pearl Fritz-Henry Volmar Sonu Dillon Michael F Shekleton David Forcione | 2013 | World Journal of Gastroenterology2013，19，23： | 14 |
| 2 | Targeting Tumor-Associated Macrophages by Anti-tumor Chinese Materia Medica显示文摘Tumor-associated macrophages(TAMs) play a key role in all stages of tumorigenesis and tumor progression. TAMs secrete different kinds of cytokines, chemokines, and enzymes to affect the progression, metastasis, and resistance to therapy depending on their state of reprogramming. Therapeutic benefit in targeting TAMs suggests that macrophages are attractive targets for cancer treatment. Chinese materia medica(CMM) is an important approach for treating cancer in China and in the Asian region. According to the theory of Chinese medicine(CM) and its practice, some prescriptions of CM regulate the body's internal environment possibly including the remodeling the tumor microenvironment(TME). Here we briefly summarize the pivotal effects of TAMs in shaping the TME and promoting tumorigenesis, invasion, metastasisand immunosuppression. Furthermore, we illustrate the effects and mechanisms of CMM targeting TAMs in antitumor therapy. Finally, we reveal the CMM's dual-regulatory and multi-targeting functions on regulating TAMs, and hopefully, provide the theoretical basis for CMM clinical practice related to cancer therapy. | PU Wei-ling SUN Li-kang GAO Xiu-mei Curzio Rüegg Muriel Cuendet Micheal O.Hottiger ZHOU Kun MIAO Lin ZHANG Yun-sha Margaret Gebauer | 2017 | Chinese Journal of Integrative Medicine2017，23，10： | 3 |
| 3 | CD40 ligand on activated platelets triggers an inflmmatry reaction of endothelial cells显示文摘 | Voiker Henn Joseph R Micheal Grafe | 1998 | Nature1998，391，5： | 1 |
| 4 | Concentrations and mass fluxes of chloroacetic acids and trifluoroacetic acid in rain and natural waters in Switzerland显示文摘 | MICHEAL B STEPHAN R M ADRIAN W | 2000 | Environ Sci Technol2000，34，： | 1 |
| 5 | Electrophysiological identification of site insensitive mechanisms in knock down resistant strains (kdr, super kdr) of the house fly larva (Musca dora estica)显示文摘 | Pepper D R Micheal P O | 1993 | Pestic Sci1993，39，： | 1 |
| 6 | Self oreinted regular arrays of carbon nanotubes and their emission properties显示文摘 | Huan Shoushan Chapline Micheal G Franklin Nathan R | 1999 | Science1999，283，： | 1 |
| 7 | VASIR: an open-source research platform for advanced iris recognition technologies 显示文摘 | Lee Y Micheals R J Filliben JJ | 2013 | J Res Natl Inst Stan2013，118，： | 1 |
| 8 | Solitary pulmonary nodule diagnosis on CT:Results of an observer study显示文摘 | Shah S K Micheal F M G Kheshini R D Z | 2005 | Acad Radiol2005，12，4： | 1 |
| 9 | Dynamic response of cable-stayed bridges to moving ve- hicles using the structural impedance method 显示文摘 | MUSHARRAF Z MICHEAL R T ANURADHA K | 1996 | Applied Mathematical Modelling1996，20，12： | 1 |
| 10 | Expression and prognostic significance of metalloproteinases and their tissue inhibitor in patients with small cell lung cancer 显示文摘 | Khokha R Micheal B Tsao M | 1999 | J Cli Oncol1999，17，5： | 1 |
| 11 | Perspective three- dimensional imaging of the musculoskelebal system显示文摘 | Deborah P Donald R Micheal A | 1986 | AJR1986，147，： | 1 |
| 12 | Managment of heart failure显示文摘 | Douglas PZ Micheal R Brain D | 2004 | Braunwald Heart Disease2004，7，： | 1 |
| 13 | Epidermal Growth Factor and its receptor in human implantation trophoblast: immunohistochemical evidence for autocrine/paracrine function 显示文摘 | Hofmann GE Micheal R | 1992 | J Clin Endocrinol Metab1992，74，： | 1 |
| 14 | Purification, characterization and molecular cloning of prophenoloxidase from Sarcophage bullata显示文摘 | Micheal R C Kiran R James B | 2000 | Insect Biochemistry and Molecular Biology2000，30，： | 1 |
| 15 | A summary review of vibration-based damage identification methods 显示文摘 | Scott W Doebling Charles R Farrar Micheal B Prime | 1998 | The Shock and Vibration Digest1998，30，91： | 1 |
| 16 | Camber and Prestress Losses inAlabama HPC Bridge Girders显示文摘 | Micheal Stallings J Barnes R W Eskildsen S | 2003 | PCIJOURNAL2003，54，5： | 1 |
| 17 | A Prospective Population-based Study of Pediatric Trauma Patients with Mild Altertations in Consciousness显示文摘 | MICHEAL W PAMELA R N JRDY B S | 2000 | Neurosurgery2000，46，5： | 1 |
| 18 | How new product introductions affect sales management strategy: The impact of type of 'Newness' of the new product显示文摘 | Micheal K Rochford L Wotruba T R | 2003 | Journal of Product Innovation Management2003，20，4： | 1 |
| 19 | Into the woods: Visual surveillance of non-cooperative and camouflaged targets in complex outdoor settings 显示文摘 | Bouh T E Micheals R J Gao X | 2001 | Proceedings of the IEEE2001，89，10： | 1 |
| 20 | Microbial community structure and biomass in surface waters during a Polar Front summer bloom along 170°W显示文摘 | Susan L Brown Micheal R | 2001 | Deep-Sea Research Ⅱ2001，，48： | 1 |
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