|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease显示文摘AIM: To evaluate the safety and feasibility of bone marrow cell (BMC) transplantation in patients with chronic liver disease on the waiting list for liver transplantation. METHODS: Ten patients (eight males) with chronic liver disease were enrolled to receive infusion of autologous bone marrow-derived cells. Seven patients were classified as Child-Pugh B and three as Child-Pugh C. Baseline assessment included complete clinical and laboratory evaluation and abdominal MRI. Approximately 50 ml of bone marrow aspirate was prepared by centrifugation in a ficoll-hypaque gradient. At least of 100 millions of mononuclear-enriched BMCs were infused into the hepatic artery using the routine technique for arterial chemoembolization for liver tumors. Patients were followed up for adverse events up to 4 mo. RESULTS: The median age of the patients was 52 years (range 24-70 years). All patients were discharged 48 h after BMC infusion. Two patients complained ofmild pain at the bone marrow needle puncture site. No other complications or specific side effects related to the procedure were observed. Bilirubin levels were lower at 1 (2.19 ± 0.9) and 4 mo (2.10 ± 1.0) after cell transplantation that baseline levels (2.78 ± 1.2). Albumin levels 4 mo after BMC infusion (3.73 ± 0.5) were higher than baseline levels (3.47 ± 0.5). International normalized ratio (INR) decreased from 1.48 (SD = 0.23) to 1.43 (SD = 0.23) one month after cell transplantation. CONCLUSION: BMC infusion into hepatic artery of patients with advanced chronic liver disease is safe and feasible. In addition, a decrease in mean serum bilirubin and INR levels and an increase in albumin levels are observed. Our data warrant further studies in order to evaluate the effect of BMC transplantation in patients with advanced chronic liver disease. | Andre Castro lyra Milena Botelho Pereira Soares luiz Flavio Maia da Silva Marcos Fraga Fortes André Goyanna Pinheiro Silva Augusto César de Andrade Mota Sheilla A Oliveira Eduardo lorens Braga Wilson Andrade de Carvalho Bernd Genser Ricardo Ribeiro dos Santos luiz Guilherme Costa lyra | 2007 | World Journal of Gastroenterology2007，13，7： | 21 |
| 2 | RANK-ligand and osteoprotegerin as biomarkers in the differentiation between periprosthetic joint infection and aseptic prosthesis loosening显示文摘AIM To assess serum levels of RANK-ligand(RANKL) and osteoprotegerin(OPG) as biomarkers for periprosthetic joint infection(PJI) and compare their accuracy with standard tests.METHODS One hundred and twenty patients presenting with a painful total knee or hip arthroplasty with indication for surgical revision were included in this prospective clinical trial. Based on standard diagnostics(joint aspirate, microbiological, and histological samples) and Musculoskeletal Infection Society consensus classification,patients were categorized into PJI, aseptic loosening,and control groups. Implant loosening was assessed radiographically and intraoperatively. Preoperative serum samples were collected and analyzed for RANKL, OPG, calcium, phosphate, alkaline phosphatase(AP), and the bone-specific subform of AP(b AP). Statistical analysis was carried out, testing for significant differences between the three groups and between stable and loose implants. RESULTS All three groups were identical in regards to age, gender, and joint distribution. No statistically significant differences in the serum concentration of RANKL(P = 0.16) and OPG(P = 0.45) were found between aseptic loosening and PJI, with a trend towards lower RANKL concentrations and higher OPG concentrations in the PJI group. The RANKL/OPG ratio was significant for the comparison between PJI and non-PJI(P = 0.005). A ratio > 60 ruled out PJI in all cases(specificity: 100%, 95%CI: 89, 11% to 100.0%) but only 30% of non-PJI patients crossed this threshold. The positive predictive value remained poor at any cut-off. In the differentiation between stable and loose implants, none of the parameters measured(calcium, phosphate, AP, and b AP) showed a significant difference, and only AP and b AP measurements showed a tendency towards higher values in the loosened group(with P = 0.09 for AP and P = 0.19 for b AP). CONCLUSION Lower RANKL and higher OPG concentrations could be detected in PJI, without statistical significance. | Max J Friedrich Matthias D Wimmer Jan Schmolders Andreas C Strauss Milena M Ploeger Hendrik Kohlhof Dieter C Wirtz Sascha Gravius Thomas M Randau | 2017 | World Journal of Orthopedics2017，8，4： | 4 |
| 3 | Analysis of multiple mycotoxins in beer employing (ultra)- high-resolution mass spectrometry 显示文摘 | MILENA Z TOMAS C MICHAL G | 2010 | Rapid Commun Mass Sp2010，24，： | 1 |
| 4 | Glycolyzed poly (ethylene terephthalate) waste and castor oil - based polyols for waterborne polyurethane adhesives containing hexamethoxymethyl melamine显示文摘 | SUZANA M C IVAN S R MILENA M | 2015 | Progress in Organic Coatings2015，78，： | 1 |
| 5 | Microstructure and theology of an acid-coagulated cheese(Karish)made with an exopolysaceharide-produeing Streptococcus thermophilus strain and its exopolysaccharide non-producing genetic variant显示文摘 | Ashraf N H Milena C Joseph F F | 2004 | Journal of Dairy Research2004，71，： | 1 |
| 6 | Use of Autologous Mesenchymal Stem Cells Derived from Bone Marrow for the Treatment of Naturally Injured Spinal Cord in Dogs显示文摘 | Euler Moraes Penha Cássio Santana Meira Elisalva Teixeira Guimar?es Marcus Vinícius Pinheiro Mendon?a Faye Alice Gravely Cláudia Maria Bahia Pinheiro Taiana Maria Bahia Pinheiro Stella Maria Barrouin-Melo Ricardo Ribeiro-dos-Santos Milena Botelho Pereira | 2014 | Stem Cells International2014，，： | 1 |
| 7 | Mapping QTL for grain yield and plant traits in a tropical maize popula- tion显示文摘 | Milena L Souza C Bento D | 2006 | Mol Breed2006，17，： | 1 |
| 8 | Tumor necrosis factor-alpha gene expression in diabetic nephropathy: relationship with urinary albumin excretion and effect of angiotensin-converting enzyme inhibition显示文摘 | Navarro JF Milena FJ Mora C | 2005 | Kidney Int Supph2005，，99： | 1 |
| 9 | In vitro and in vivo behavior of Ca and P enriched anodized titanium 显示文摘 | MILENA F ALBERTO C GIANNI R | 1999 | 20 :1587-15941999，20，： | 1 |
| 10 | In vitro and in vivo behaviour of Ca- and P-enriched anodized titanium 显示文摘 | Alberto C Gianni R | 1999 | Biomaterials1999，，20： | 1 |
| 11 | The role of exopolysaccharide produced by Lactococcus lactis subsp, cremoris in structure forma- tion and recovery of acid milk gels显示文摘 | Eleana K Zhutuan Miao Milena C | 2011 | International Dairy Journal2011，21，9： | 1 |
| 12 | The effect of pulsed electromagnetic fields on the osteointegration of hydroxyapatite implants in cancellous bone:a morphologic and microstructural in vivo study 显示文摘 | Milena F Ruggero C Valerio C | 2002 | J Orthop Res2002，20，4： | 1 |
| 13 | Accelerated reliability growth testing and data analysis method 显示文摘 | Milena K Bose C | 2006 | Proceeding annual reliability and maintainability symposium Newport beach CA2006，2006，： | 1 |
| 14 | Renal pro-inflammatory cytokine gene expression in diabetic nephropathy:effect of angiotensin-converting enzyme inhibition and pentoxifylline administration显示文摘 | Navarro JF Milena FJ Mora C | 2006 | Am J Nephrol2006，26，6： | 1 |
| 15 | Influence of Heat Treatment on the Volatile Compounds of Milk 显示文摘 | GIOVANNA C MILENA P RICCAR330 L | 1997 | Food Chem- istry1997，45，8： | 1 |
| 16 | Renal pro-inflammatory cytokine gene expression in diabetic nephropathy:effect of angiotensinconverting enzyme inhibition and pentoxifylline administration显示文摘 | Navarro JF Milena FJ Mora C | 2006 | Am J Nephrol2006，26，6： | 1 |
| 17 | Persistence,clearance and reinfection regarding six high risk human papillomavirus types in Colombian women:a follow-up study显示文摘 | Sara C Soto-De Leon Luisa Del Rio-Ospina Milena Camargo | 2014 | BMC Infectious Diseases2014，14，： | 1 |
| 18 | Tumor necrosis factor-alpha gene expression in diabetic nephropathy: relationship with urinary albumin excretion and effect of angiotersin-converting enzyme inbition 显示文摘 | Navarro JF Milena FJ Mora C | 2005 | Kidney Int Suppl2005，99，： | 1 |
| 19 | Renal pro-inflammatory cytokine gene expression in diabetic nephropathy: effect of enzyme inhibition and pentoxifylline administration 显示文摘 | Navarro JF Milena FJ Morn C | 2006 | Am J Nephrol2006，26，6： | 1 |
| 20 | Programming infant gut microbiota: influence of dietary and environmental factors显示文摘 | Tatiana Milena Marques Rebecca Wall R Paul Ross Gerald F Fitzgerald C Anthony Ryan Catherine Stanton | 2010 | Current Opinion in Biotechnology2010，，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员