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| 1 | Para-aortic lymph node involvement should not be a contraindication to resection of pancreatic ductal adenocarcinoma显示文摘BACKGROUND Para-aortic lymph nodes(PALN)are found in the aortocaval groove and they are staged as metastatic disease if involved by pancreatic ductal adenocarcinoma(PDAC).The data in the literature is conflicting with some studies having associated PALN involvement with poor prognosis,while others not sharing the same results.PALN resection is not included in the standard lymphadenectomy during pancreatic resections as per the International Study Group for Pancreatic Surgery and there is no consensus on the management of these cases.AIM To investigate the prognostic significance of PALN metastases on the oncological outcomes after resection for PDAC.METHODS This is a retrospective cohort study of data retrieved from a prospectively maintained database on consecutive patients undergoing pancreatectomies for PDAC where PALN was sampled between 2011 and 2020.Statistical comparison of the data between PALN+and PALN-subgroups,survival analysis with the Kaplan-Meier method and risk analysis with univariable and multivariable time to event Cox regression analysis were performed,specifically assessing oncological outcomes such as median overall survival(OS)and disease-free survival(DFS).RESULTS 81 cases had PALN sampling and 17(21%)were positive.Pathological N stage was significantly different between PALN+and PALN-patients(P=0.005),while no difference was observed in any of the other characteristics.Preoperative imaging diagnosed PALN positivity in one case.OS and DFS were comparable between PALN+and PALN-patients with lymph node positive disease(OS:13.2 mo vs 18.8 mo,P=0.161;DFS:13 mo vs 16.4 mo,P=0.179).No difference in OS or DFS was identified between PALN positive and negative patients when they received chemotherapy either in the neoadjuvant or in the adjuvant setting(OS:23.4 mo vs 20.6 mo,P=0.192;DFS:23.9 mo vs 20.5 mo,P=0.718).On the contrary,when patients did not receive chemotherapy,PALN disease had substantially shorter OS(5.5 mo vs 14.2 mo;P=0.015)and DFS(4.4 mo vs 9.8 mo;P<0.001).PALN involvement was not identified as an independent predictor for OS after multivariable analysis,while it was for DFS doubling the risk of recurrence.CONCLUSION PALN involvement does not affect OS when patients complete the indicated treatment pathway for PDAC,surgery and chemotherapy,and should not be considered as a contraindication to resection. | Rupaly Pande Shafiq Chughtai Manish Ahuja Rachel Brown David C Bartlett Bobby V Dasari Ravi Marudanayagam Darius Mirza Keith Roberts John Isaac Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastrointestinal Surgery2022，14，5： | 2 |
| 2 | Prolonged coagulopathy related to superwarfarin overdose显示文摘 | SARIN S MUKHTAR H MIRZA M A | 2005 | Ann Intern Med2005，142，： | 1 |
| 3 | Generation of large numbers of immature and mature dendritic cells from rat bone marrow cultures显示文摘 | Talmor M Mirza A Turley S | 1998 | Eur J Immunol1998，28，3： | 1 |
| 4 | Site-directed mutagenesis of a conserved hexapeptide in the paraxovirus hemagglutininneuraminidase glycoprotein: Effects on antigenic structure and function显示文摘 | Mirza A M Deng R Lorio R M | 1994 | J Virol1994，68，： | 1 |
| 5 | A retrospective comparision of endonasal KTP laser dacryocystorhinostomy versus external dacryocystorhinostomy显示文摘 | Mirza S A Barmani A Douglas SA | 2002 | Clin Otolaryngol2002，27，： | 1 |
| 6 | Posterior reversible encephalopathy syndrome: a variant of hypertensive encephalopathy 显示文摘 | Mirza A | 2006 | J Clin Neurosci2006，13，5： | 1 |
| 7 | Outcome of postradiation osteosarcoma does not correlate with chemotherapy response显示文摘 | LEWIS V O RAYMOND K MIRZA A N | 2006 | C/in Orthop Related Res2006，450，： | 1 |
| 8 | Frequent periodic leg movement during sleep is associated with left ventricular hypertrophy and adverse cardiovascular outcomes显示文摘 | Mirza M Shen W K Soft A | | 0，，07： | 1 |
| 9 | Fracture Energy of Weakly Reinforced Concrete Beams显示文摘 | Azad A Mirza M Chan P | | 0，，01： | 1 |
| 10 | A staged treatment plan for the management of Type II and Type IIIA open ealeaneus fractures显示文摘 | Mehta S Mirza A J Dunbar RP | 2010 | J Orthop Tranma2010，24，3： | 1 |
| 11 | Posterior reversible encephalopathy syndrome:A variant of hypertensive encephalopathy 显示文摘 | Mirza A | 2006 | J Clin Neurosci2006，13，： | 1 |
| 12 | Production of phytohormones by the nitrogen fixation bacteria isolated from sugarcane显示文摘 | SHAFIQ H MIRZA M S MAUK K A | 1999 | Biohorizons1999，2，1： | 1 |
| 13 | Human survivin is negatively regulated by wild type p5f and Darticipates in p53 he pendent apoptotic pathway显示文摘 | Mirza A McGuirk M Hockenberry TN | 2002 | Oncogene2002，21，17： | 1 |
| 14 | Macrophage in- flammatory protein-3 beta enhances IL-10 production by activated human peripheral blood monocytes and T cells显示文摘 | Byrnes HD Kaminski H Mirza A | 1999 | J Immunol1999，163，： | 1 |
| 15 | Portal vein thrombosis in adult undergoing live transplantation:risk factors screening man- agement and outcome 显示文摘 | Yerdel M A Gunsun B Mirza D | 2000 | Transplantation2000，69，9： | 1 |
| 16 | Comparative strength analyses of conerete-rncased steel composite columns 显示文摘 | Mirza S A Laeroix E A | 2004 | Journal of Structural Engineering2004，130，12： | 1 |
| 17 | Ameliorative effect of Koflet formulations against pyridine-induced pharyngitis in rats 显示文摘 | Viswanatha C L Rafiq M Thippeswamy A H M Yuvaraj H C Kavya K J Mirza R B Suryakant A Mohammed A Patki P S Pushpalatha H B Prafulla S C Shyam R | 2014 | Toxicology Reports2014，1，： | 1 |
| 18 | Engineered intermonomeric disulfide bonds in the globular domain of Newcastle disease virus hemagglutinin-neuraminidase protein:implications for the mechanism of fusion promotion显示文摘 | Mahon P J Mirza A M Musich T A | 2008 | J Virol2008，82，10： | 1 |
| 19 | Arginine and urea metabolism in the liver graft: a study using microdialysis in human orthotopic liver transplantation显示文摘 | SILVA M A MIRZA D F BUCKELS J A | 2006 | Transplantation2006，82，10： | 1 |
| 20 | Fusion deficiency induced by mutations at the dimer interface in the Newcastle disease virus hemagglutinin-neuraminidase is due to a temperature-dependent defect in receptor binding显示文摘 | Corey E A Mirza A M Levandowsky E | 2003 | J Virol2003，77，77： | 1 |
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