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| 1 | Pathogenic mechanisms of pancreatitis显示文摘Pancreatitis is inflammation of pancreas and caused by a number of factors including pancreatic duct obstruction, alcoholism, and mutation in the cationic trypsinogen gene. Pancreatitis is represented as acute pancreatitis with acute inflammatory responses and; chronic pan-creatitis characterized by marked stroma formation with a high number of infiltrating granulocytes(such as neutrophils, eosinophils), monocytes, macrophages and pancreatic stellate cells(PSCs). These inflammatory cells are known to play a central role in initiating and promoting inflammation including pancreatic fibrosis, i.e., a major risk factor for pancreatic cancer. A number of inflammatory cytokines are known to involve in pro-moting pancreatic pathogenesis that lead pancreatic fibrosis. Pancreatic fibrosis is a dynamic phenomenon that requires an intricate network of several autocrine and paracrine signaling pathways. In this review, we have provided the details of various cytokines and molecular mechanistic pathways(i.e., Transforming growth factor-β/SMAD, mitogen--activated protein kinases, Rho kinase, Janus kinase/signal transducers and activators, and phosphatidylinositol 3 kinase) that have a critical role in the activation of PSCs to promote chronic pancreatitis and trigger the phenomenon of pancreatic fibrogenesis. In this review of literature, we discuss the involvement of several pro-inflammatory and anti-inflammatory cytokines, such as in interleukin(IL)-1, IL-1β, IL-6, IL--8 IL-10, IL-18, IL--33 and tumor necrosis factor-α, in the pathogenesis of disease. Our review also highlights the significance of several experimental animal models that have an important role in dissecting the mechanistic pathways operating in the development of chronic pancreatitis, including pancreatic fibrosis. Additionally, we provided several intermediary molecules that are involved in major signaling pathways that might provide target molecules for future therapeutic treatment strategies for pancreatic pathogenesis. | Murli Manohar Alok Kumar Verma Sathisha Upparahalli Venkateshaiah Nathan L Sanders Anil Mishra | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，1： | 21 |
| 2 | Non-Mendelian inheritance of DNA-induced inositol independence in Neurospora显示文摘 | Mishra N C Tatum E L | 1973 | Proc Natl Acad Sci USA1973，70，12： | 1 |
| 3 | Twinning and texture development in two Mg alloys subjected to loading along three dif- ferent strain paths显示文摘 | JIANG L JONAS J J MISHRA R K | 2007 | Acta Materialia2007，55，11： | 1 |
| 4 | Accurate measurement of Q-factors of isolated dielectric resonator显示文摘 | MONGIA R K LAROSE C L MISHRA S R BHARTIA P | 1994 | IEEE Transactions on Microwave Theory and Techniques1994，42，8： | 1 |
| 5 | Insights into heap bioleaching of low grade chalcopyrite ores--A pilot scale study显示文摘 | PANDA S SAN JAY K SUKLA L B PRADHAN N SUBBAIAH T MISHRA B K PRASAD M S R RAY S K | 2012 | Hydrometallurgy2012，125，： | 1 |
| 6 | The nanostructured origin of deformation twinning显示文摘 | YU Q QI L CHEN K MISHRA R K LI J MINOR A M | 2012 | Nano Letters2012，12，： | 1 |
| 7 | The role of TGF-β and Wnt signaling in gastrointestinal stem cells and cancer 显示文摘 | Mishra L Shetty K Tang Y | 2005 | Oncogene2005，24，37： | 1 |
| 8 | Microstructures of precipitation-hardened SmCo permanent magnets 显示文摘 | Rabenberg L Mishra R K Thomas G | 1982 | J Appl Phys1982，53，3： | 1 |
| 9 | Production and characterization of Hesperetin nanosuspensions for der- mal delivery 显示文摘 | Mishra PR A1 Shaal L Mtiller RH | 2009 | Int J Pharm2009，371，12： | 1 |
| 10 | Effectiveness of CEO pay-for-performance显示文摘 | Mishra C S McConaughy D L Gobeli D H | 2000 | Review of Financial Economics2000，9，1： | 1 |
| 11 | Inhibition of CO2 corrosion of mild steel by imidazoline and their precursor 显示文摘 | Jovancievic V Olsorn D L Mishra B | 1999 | Corrosion1999，55，5： | 1 |
| 12 | Texture and mechanical behavior evolution of age-hardenable Mg-Nd-Zn extrusions during aging treatment显示文摘 | LAN M A MISHRA R K PENG L M LUO A A DING Wen-jiang SACHDEV A K | 2011 | Mater Sci EngA2011，529，： | 1 |
| 13 | Oxidative stress and heart failure in altered thy- roid states显示文摘 | Mishra P Samanta L | 2012 | The scientific World Journal2012，，： | 1 |
| 14 | Selective single-pot oxida-tion of cyclohexane by molecular oxygen in presence ofbis (maltolato) oxovanadium complexes covalently bondedto carbamated modified silica gel 显示文摘 | Mishra G S Pombeiro A J L | 2005 | Journal of Molec-ular Catalysis A : Chemical2005，239，： | 1 |
| 15 | Uranium recovery from phosphoric acid by solvent extraction using a synergistic mixture of di-nonyl phenyl phosphoric acid and tri-n-butyl phosphate 显示文摘 | Harvinderpal Singh Mishra S L Vijayalakshmi R | 2004 | Hydrometallurgy2004，，73： | 1 |
| 16 | SCS-CN based continuous simulation model for hydrologic forecasting 显示文摘 | Geetha K Mishra S K Eidho T L | 2008 | Water Researches Management2008，22，： | 1 |
| 17 | A review on the synthesis of Y-Ba-Cu-oxide powder显示文摘 | PATHAKAND L C and MISHRA S K | 2005 | Superconductor Science and Technology2005，18，： | 1 |
| 18 | Genome-wide analysis of microsatellite repeats in humans:their abundance and density in specific genomic regions显示文摘 | Subramanian S Mishra R K Singh L | | 0，，2： | 1 |
| 19 | Numerical modeling of formability of extruded magnesium alloy tubes显示文摘 | J. Lévesque K. Inal K.W. Neale R.K. Mishra | 2009 | International Journal of Plasticity2009，，1： | 1 |
| 20 | Synthetie antimicrobial oligomers induce a composition-dependent topological transition in membrane显示文摘 | YANG L GORDON V D MISHRA A | 2007 | J Am Chem Soc2007，129，12： | 1 |
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