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| 1 | Ocular drug delivery systems:An overview显示文摘The major challenge faced by today's pharmacologist and formulation scientist is ocular drug delivery. Topical eye drop is the most convenient and patient compliant route of drug administration,especially for the treatment of anterior segment diseases. Delivery of drugs to the targeted ocular tissues is restricted by various precorneal,dynamic and static ocular barriers. Also,therapeutic drug levels are not maintained for longer duration in target tissues. In the past two decades,ocular drug delivery research acceleratedly advanced towards developing a novel,safe and patient compliant formulation and drug delivery devices/techniques,which may surpass these barriers and maintain drug levels in tissues. Anterior segment drug delivery advances are witnessed by modulation of conventional topical solutions with permeation and viscosity enhancers. Also,it includes development of conventional topical formulations such as suspensions,emulsions and ointments. Various nanoformulations have also been introduced for anterior segment ocular drug delivery. On the other hand,for posterior ocular delivery,research has been immensely focused towards development of drug releasing devices and nanoformulations for treating chronic vitreo-retinal diseases. These novel devices and/or formulations may help to surpass ocular barriers and associated side effects with conventional topicaldrops. Also,these novel devices and/or formulations are easy to formulate,no/negligibly irritating,possess high precorneal residence time,sustain the drug release,and enhance ocular bioavailability of therapeutics. An update of current research advancement in ocular drug delivery necessitates and helps drug delivery scientists to modulate their think process and develop novel and safe drug delivery strategies. Current review intends to summarize the existing conventional formulations for ocular delivery and their advancements followed by current nanotechnology based formulation developments. Also,recent developments with other ocular drug delivery strategies employing in situ gels,implants,contact lens and microneedles have been discussed. | Ashaben Patel Kishore Cholkar Vibhuti Agrahari Ashim K Mitra | 2013 | World Journal of Pharmacology2013，2，2： | 18 |
| 2 | Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells显示文摘基础切除修理(BER ) 是为由消除损坏的几打维持 genomic 完整的 evolutionarily 保存的进程(氧化或烷基 ated ) 或内长地被产生或由 genotoxicants 导致了的不恰当的库,主要反应的氧种类(ROS ) 。BER 包含由脱氧核糖核酸 glycosylase 以基础切除开始的 4-5 步骤,由通常包含 AP-endonuclease (无尾猿) 产生 3' 的一条普通小径列在后面哦在损坏地点的终点,与由脱氧核糖核酸连接酶封上的 DNA 和刻痕由修复合成列在后面。这条小径也负责修理脱氧核糖核酸单个海滨与 ROS 直接产生的堵住的终点决裂。将近所有 glycosylases,比他们特别地为氧化的底的底层损害少得多,宽广、重叠的底层变化,并且能用作备份酶体内。相反,哺乳动物的房间编码仅仅一无尾猿, APE1,不同于在更低的有机体的二无尾猿。尽管有全面类似,有在哺乳动物的不同潜水艇小径的 BER 比在 E 更复杂。关口 i。glycosylases 与下游的蛋白质形成建筑群经由不同潜水艇小径执行有效修理哪个之一,负责因为海滨的修理与 NEIL 家庭 glycosylases 或由 ROS 产生的 3' 磷酸盐终点决裂,要求多核苷酸 kinase 的磷酸酶活动而不是 APE1。不同建筑群可以利用不同 DNA 和 ligases。哺乳动物的 glycosylases 非在终点之一保存了延期、为酶的活动非必需却为和另外的 BER 并且非的相互作用需要 -- 为指向的复杂形成和细胞器的 BER 蛋白质。哺乳动物的酶 covalently 有时被修改它可以影响活动和复杂形成。这评论的焦点在在为氧化损坏的哺乳动物的 BER 的早步上。 | Muralidhar L Hegde Tapas K Hazra Sankar Mitra | 2008 | Cell Research2008，18，1： | 15 |
| 3 | Formation of epitaxial and polycrystalline films of the electron doped system La1-xCexMnO3 through pulsed laser deposition 显示文摘 | Mitra C Raychaudhuri P Dhar S K Nigam A K Pinto R | 2001 | Journal of Magnetism and Magnetic Materials2001，22，： | 1 |
| 4 | Effect of rare earth elements on microstmcture and oxidation behaviour in TIG weldments of MS1316L stainless steel 显示文摘 | Samanta S K Mitra S K Pal T K | 2006 | Materials Science and Engineering: A2006，430，2： | 1 |
| 5 | Multisensor image fusion using the wavelet transform 显示文摘 | LI H MANJUNATH B S MITRA S K | 1995 | Graph Models Image Process1995，57，3： | 1 |
| 6 | Rough fuzzy mlp: knowledge encoding and classification 显示文摘 | Banerjee M Mitra S and Pal S K | 1998 | IEEE Transactions on Neural Networks1998，9，6： | 1 |
| 7 | A simple method for designing high-quality prototype filters for Mband pseudo QMF bank显示文摘 | | 1995 | IEEE TRANSACTIONS ON SIGNA PROCESSING1995，43，4： | 1 |
| 8 | 显示文摘 | Panda A K Rao V | 2001 | Appl Surf Sci2001，，182： | 1 |
| 9 | Studies on jutereinforced composites,its limitations,and some solutions through chemical modifications of fibers显示文摘 | MITRA B C BASAK R K SARKAR M | 1998 | Journal of Applied Polymer Science1998，67，6： | 1 |
| 10 | Focal adhesion kinase: in command and control of cell motility 显示文摘 | Mitra S K Hanson D A Schlaepfer D D | 2005 | Nat Rev Mol Cell Biol2005，6，1： | 1 |
| 11 | Predictors of serum retinol in children with shigellosis 显示文摘 | MITRA A K ALVAREZ J O WAHED M A | 1998 | Am J Clin Nutr1998，68，5： | 1 |
| 12 | Effect of particle size on the thermal expansion of TiC/Al XD composites 显示文摘 | Xu Z R Chawla K K Mitra R | 1994 | Scripta Metall Mater1994，31，11： | 1 |
| 13 | Image resizing in the compressed domain using subband DCT 显示文摘 | Mukherjee J Mitra S K | 2002 | IEEE Transactions on Circuits and Systems for Video Technology2002，12，6： | 1 |
| 14 | Development of a novel formulation containing poly (D, L-lactide-coglycolide) microspheres dispersed in PLGA-PEG-PLGA gel for sustained delivery of ganciclovir显示文摘 | Duvvuri S Janoria K G Mitra A K | 2005 | Journal of Controlled Release2005，108，2： | 1 |
| 15 | Saturation-based adaptive inverse gradient interpolation for Bayer pattern images显示文摘 | Cai C Yu T H Mitra S K | 2001 | IEEE Proceedings-Vision2001，148，3： | 1 |
| 16 | Heat transfer enhancement of finned oval tubes with staggered punched Longitudinal vortex generators显示文摘 | Chen Y Fiebig M Mitra N K | 2000 | International Journal of heat and mass transfer2000，43，： | 1 |
| 17 | An adaptive control strategy for DSTATCOM applications in an electric ship power system显示文摘 | Mitra P Venayagamoorthy G K | 2010 | IEEE Trans on Power Electronics2010，25，1： | 1 |
| 18 | Exposure to As, Cd and Pb-mixture impairs myelin and axon development in rat brain,optic nerve and retina显示文摘 | Rai N K Ashok A Rai A Tripathi S Nagar G K Mitra K | 2013 | Toxicology and Applied Pharmacology2013，273，2： | 1 |
| 19 | The minus partial order and the shorted matrix 显示文摘 | Mitra S K | 1986 | Linear Algebra and Its Application1986，82，： | 1 |
| 20 | Multi-Layer Perceptron, Fuzzy Sets And Classification显示文摘 | Pal S K Mitra S | 1992 | IEEE Trans Neural networks1992，3，： | 1 |
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