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| 1 | Introducing an enhanced recovery after surgery program in colorectal surgery:A single center experience显示文摘AIM:To study the implementation of an enhanced recovery after surgery(ERAS)program at a large University Hospital from'pilot study'to'standard of care'.METHODS:The study was designed as a prospective single centre cohort study.A prospective evaluation of compliance to a protocol based on full application of all ERAS principles,through the progressive steps of its implementation,was performed.Results achieved in the initial pilot study conducted by a dedicated team(n=47)were compared to those achieved in the shared protocol phase(n=143)three years later.Outcomes were length of postoperative hospital stay,readmission rate,compliance to the protocol and morbidity.Primary endpoint was the description of the results and the identification of critical issues of large scale implementation of an ERAS program in colorectal surgery emerged in the experience of a single center.Secondary endpoint was the identification of interventions that have been proven to be effective for facilitating the transition from traditional care pathways to a multimodal management protocol according to ERAS principles in colorectal surgery at a single center.RESULTS:During the initial pilot study(March 2009 to December 2010;47 patients)conducted by a dedicated multidisciplinary team,compliance to the items of ERAS protocol was 93%,with a median length of hospital stay(LOS)of 3 d.Early anastomotic fistulas were observed in 2 cases(4.2%),which required reoperation(Clavien-Dindo gradeⅢb).None of the patients had been discharged before the onset of the complication,which could therefore receive prompt treatment.There were also four(8.5%)minor complications(ClavienDindo gradeⅡ).Thirty days readmission rate was 4%.Perioperative mortality was nil.After implementation of the protocol throughout the Hospital in unselected patients(May 2012 to December 2012;147 patients)compliance was 74%,with a median LOS of 6 d.Early anastomotic fistulas were observed in 11 cases(7.7%),5(3.5%)of which required reoperation(Clavien-Dindo gradeⅢb).Two early anastomotic fistulas were treated by radiologic/endoscopic manoeuvres and 4 were treated conservatively.There were also 36(25.2%)minor complications,21(14.7%)of which were Clavien-Dindo gradeⅡand 15(10.5%)of which were Clavien-Dindo gradeⅠ.Only two patients whose course was adversely affected by the development of an anastomotic leak had been discharged before the onset of the complication itself,requiring readmission.Readmission rate within 30 d was 4%.Perioperative mortality was 1%.CONCLUSION:Our results confirm that introduction of an ERAS protocol for colorectal surgery allows quickerpostoperative recovery and shortens the length of stay compared to historical series. | Stefano Bona Mattia Molteni Riccardo Rosati Ugo Elmore Pietro Bagnoli Roberta Monzani Monica Caravaca Marco Montorsi | 2014 | World Journal of Gastroenterology2014，20，46： | 30 |
| 2 | Family history of irritable bowel syndrome is the major determinant of persistent abdominal complaints in young adults with a history of pediatric recurrent abdominal pain显示文摘瞄准:与周期性的腹的疼痛(敲击) 或急躁的肠症候群(IBS ) 的以前的历史估计少年的迟了的结果。方法:有敲击的一组 67 个孩子从 1986 年 1 月指了部门到 1995 年 12 月被跟随在上面在 5 和 13 之间,在借助于一个结构化的电话的起始的诊断以后的年会见。我们假设了有坚持的成年象 IBS 一样症状的那些病人将是显著地更可能没有坚持的腹的抱怨与成年人比较报导 IBS 的家庭历史。结果:从 52 轨道有能力的题目, 15 被发现在后续(29%) 介绍象 IBS 一样症状而多数(37 个题目) 不。有象 IBS 一样症状的题目更多半是几乎三次与不抱怨的题目(40.0% 对 16.0%) 相比与类似的症状介绍至少一个兄弟,分别地(P <
0.05 在学生 t ) 。有象 IBS 一样症状的题目也报导了额外肠的症状的更高的流行,例如背疼痛, fibromyalgia,头疼,疲劳和睡觉骚乱。结论:学习证实显示那小儿科的敲击的以前的观察能预言 IBS 的以后的开发。后者看起来被症状的 intrafamilial 聚集极大地影响,可能通过听说特定的病行为。 | Fabio Pace Giovanna Zuin Stefania Di Giacomo Paola Molteni Valentina Casini Massimo Fontana Gabriele Bianchi Porro | 2006 | World Journal of Gastroenterology2006，12，24： | 2 |
| 3 | The ECMWF ensemble prediction system:methodology and validation显示文摘 | Molteni F Buizza R Palmer T N | 1996 | Q J R Meteorol Soc1996，122，529： | 2 |
| 4 | Mucosal Healing Predicts Late Outcomes After the First Course of Corticosteroids for Newly Diagnosed Ulcerative Colitis显示文摘 | Sandro Ardizzone Andrea Cassinotti Piergiorgio Duca Cristina Mazzali Chiara Penati Gianpiero Manes Riccardo Marmo Alessandro Massari Paola Molteni Giovanni Maconi Gabriele Bianchi Porro | 2011 | Clinical Gastroenterology and Hepatology2011，，6： | 2 |
| 5 | Tropical-extratropical interaction associated with the 30-60 day oscillation and its impact on medium and extend range prediction显示文摘 | Ferranti L Palmer T N Molteni F | 1990 | J Atmos Sci1990，47，18： | 2 |
| 6 | Growth hormone regulates amrnoniagenesis in canine renal proximal tubule segments显示文摘 | Chobanian MC Julin CM Molteni KH | 1992 | Am J Physiol1992，262，： | 1 |
| 7 | Control of radiation-induced pneumopathy and lung fibrosis by angiotensin-converting enzyme inhibitors and an angiotensin Ⅱ type 1 receptor blocker显示文摘 | MOLTENI A MOULDER J E COHEN E F | 2000 | Int J Radiat Biol2000，76，4： | 1 |
| 8 | Prevalence of hospital-associated infections can be decreased effectively in developing countries显示文摘 | Ogwang M Daniele P Molteni T | 2013 | J Hosp Infect2013，84，2： | 1 |
| 9 | IL-7/IL-7reeeptor system regulation following IL-2 immunotherpy in HIV-infeeted patients 显示文摘 | Marchetti G Meroni L Molteni C | 2004 | Antivir Ther2004，9，： | 1 |
| 10 | Effect of an angiotensin Ⅱ receptor blocker and two angiotensin converting enzyme inhibitors on transforming growth factor-beta (TGF-beta) and alpha-actomyosin (alpha SMA), important mediators of radiation-induced pneumopathy and lung fibrosis显示文摘 | MOLTENI A WOLFE L F WARD W F | 2007 | Current Pharmaceutical Design2007，13，13： | 1 |
| 11 | Vitamin A deficiency injures lung and liver parenchyma and impairs function of rat type I1 pneumocytes 显示文摘 | Baybutt RC Hu L Molteni A | 2000 | J Nutr2000，130，5： | 1 |
| 12 | Estradiol receptor-binding protein in head and neck neoplastic and normal tissue显示文摘 | Molteni A Warpeha RL Brizio-Molteni L | 1981 | Arch Surg1981，116，2： | 1 |
| 13 | Interaction of the human prion PrP(106-126) sequence with copper (Ⅱ), mangancse(Ⅱ), and zinc(Ⅱ) : NMR and EPR studies 显示文摘 | Gaggelli E Bernardi F Molteni E | 2005 | J Am Chem Snc2005，127，3： | 1 |
| 14 | Outcome research in gastroenterology: the case of gastroesophageal reflux disease (GERD)显示文摘 | Pace F Molteni P Wiklund I | 2006 | Drug Develop Res2006，67，3： | 1 |
| 15 | Neuronal plasticity: a linkbetween stress and mood disorders 显示文摘 | Calabrese F Molteni R Racagni G | 2009 | Psychoneuroendocrinology2009，，： | 1 |
| 16 | An energy-efficient controller for shading devices self-adapting to the user wishes显示文摘 | Guillemin A Molteni S | 2002 | Building and Environment2002，37，11： | 1 |
| 17 | Clinical manifestationsand socio-economic impact of influenza among healthy childrenin the Community 显示文摘 | Esposito S Cantarutti L Molteni CG | 2011 | J Infect2011，62，5： | 1 |
| 18 | Inhibition of Star3 increases doxorubicin sensitivity in a human metastatic breast cancer cell line显示文摘 | Gariboldi MB Ravizza R Molteni R | 2007 | Cancer Lett2007，258，2： | 1 |
| 19 | Determinants of cities* GHG emissions: a comparison of seven global cities 显示文摘 | Croci E Melandri S Molteni T | 2011 | International Journal of Climate Change Strategies and Management2011，3，3： | 1 |
| 20 | Exercise reverses the harmful effects of consumption of a high-fat diet on synaptic and behavioral plasticity associated to the action of brainderived neurotrophic factor显示文摘 | Molteni R Wu A Vaynman S | 2004 | Neuroscience2004，123，： | 1 |
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