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| 1 | Molecular and phenotypic characterization of human amniotic fluid cells and their differentiation potential显示文摘学习的主要目标是多识别人的新奇来源有势力房间,克服涉及胚胎的干细胞研究和很成年的干细胞的有限可获得性的道德的问题。羊膜的液体房间(声频抗流圈) 习惯性地为出生前的诊断被获得并且能在 vitro 被扩展;他们的起源和性质的不过当前的知识是有限的。声频抗流圈的二十件样品在文化暴露于 adipogenic, osteogenic,神经原并且 myogenic 媒介。区别用免疫细胞化学, RT-PCR 并且西方的弄污被评估。在处理前,声频抗流圈显示出异构的形态学。他们为 MyoD, Myf-5, MRF4, Myogenin 和 Desmin 是否定的但是为由 RT-PCR 的 osteocalcin, PPARgamma2, GAP43, NSE, Nestin, MAP2, GFAP 和贝它导管素 III 积极。房间表示了 Oct-4, Rex-1 和 Runx-1,它描绘无差别的干细胞状态。由免疫细胞化学,他们表示了 neural-glial 蛋白质,间充质、上皮的标记。在文化以后,当占优势的细胞的部件是 fibroblastic 时,声频抗流圈区分了进 adipocytes 和造骨细胞。就算没有 neuronal 形态学是可检测的,早、迟了的 neuronal 抗原仍然是在在神经特定的媒介的 2 星期文化以后的现在。我们的结果提供人的羊膜的液体与为几个系显示出茎和织物特定的基因 / 蛋白质存在的多系潜力包含祖先房间的证据。 | Patrizia Bossolasco Tiziana Montemurro Lidia Cova Stefano Zangrossi Cinzia Calzarossa Simona Buiatiotis Davide Soligo Silvano Bosari Vincenzo Silani Giorgio Lambertenghi Deliliers PaoloRebulla LorenzaLazzari | 2006 | Cell Research2006，16，4： | 20 |
| 2 | 胸苷酸合成酶和拓扑异构酶-1及Ki-67对伊立替康联合5-氟脲嘧啶治疗晚期大肠癌的预测价值显示文摘目的探讨胸苷酸合成酶(TS)、拓扑异构酶1(Topo1)和肿瘤增殖指标Ki67对伊立替康(CPT11)联合5氟脲嘧啶(5Fu)治疗晚期大肠癌患者的临床疗效和预后的预测价值。方法采用免疫组化方法检测了CPT11+5Fu一线治疗78例大肠癌患者的TS、Topo1和Ki67的表达,并与化疗疗效和患者的临床预后进行了分析。结果各检测指标的表达水平与临床疗效之间无关,但是临床预后不同。其中,TS低表达患者表现明显长的肿瘤进展时间(TTP,P<0.05)和存活期(OS,P<0.05);Ki67低表达也预示长的OS(P<0.05)。与单个指标相比较,两个指标的联合也不能预测临床疗效,但是对预后的判断作用明显提高。TS低表达、Ki67低表达以及TS和Ki67均低表达患者的中位TTP分别为9,8和17个月(P=0.02);TS低表达、Topo1低表达以及TS和Topo1均低表达患者的中位TTP分别为9,9和13个月(P=0.03);而Topo1低表达、Ki67低表达、Ki67和Topo1均低表达患者的中位TTP分别为8,9和11个月(P=0.05)。其中任何两个指标均低表达肿瘤的TTP和OS均明显长于高表达者(P<0.05)。结论TS、Topo1和Ki67不能预测大肠癌患者CPT11+5Fu的疗效,但对其临床预后有一定的预测作用。其中任何两个指标的联合,比单一指标对患者预后的预测价值明显提高。 | 徐建明 朱步东 Mangia Anita Simone Gianni Montemurro Severino Giuliani Francesco Maiello Evaristo Colucci Giuseppe Paradiso Angelo | 2005 | 中华肿瘤杂志2005，27，5： | 9 |
| 3 | Multiple responses optimization in the development of a headspace gas chromatography method for the determination of residual solvents in pharmaceuticals显示文摘An efficient generic static headspace gas chromatography(HSGC) method was developed,optimized and validated for the routine determination of several residual solvents(RS) in drug substance,using a strategy with two sets of calibration.Dimethylsulfoxide(DMSO) was selected as the sample diluent and internal standards were used to minimize signal variations due to the preparative step.A gas chromatograph from Agilent Model 6890 equipped with flame ionization detector(FID) and a DB-624(30 m × 0.53 mm i.d.,3.00 μm film thickness) column was used.The inlet split ratio was 5:1.The influencing factors in the chromatographic separation of the analytes were determined through a fractional factorial experimental design.Significant variables:the initial temperature(IT),the final temperature(FT) of the oven and the carrier gas flow rate(F) were optimized using a central composite design.Response transformation and desirability function were applied to find out the optimal combination of the chromatographic variables to achieve an adequate resolution of the analytes and short analysis time.These conditions were 30 ℃ for IT,158 ℃ for FT and 1.90 mL/min for F.The method was proven to be accurate,linear in a wide range and very sensitive for the analyzed solvents through a comprehensive validation according to the ICH guidelines. | Carla M.Teglia Milagros Montemurro María M.De Zan María S.Cmara | 2015 | Journal of Pharmaceutical Analysis2015，5，5： | 8 |
| 4 | H pylori status and angiogenesis factors in human gastric carcinoma显示文摘AIM: To investigate H pylori expression in gastric cancer patients in relation to primary tumor angiogenic markers, such as microvessel density (MVD), thymidine phospho- rylase (TP), vascular endothelial growth factor receptor-1 (VEGF-R1), p53 and circulating VEGF levels. METHODS: Angiogenic markers were analyzed immu- nohistochemically in 56 primary gastric cancers. H pylori cytotoxin (vacA) and the cytotoxin-associated gene (cagA) amplification were evaluated using PCR assay. Serum H pylori IgG antibodies and serum/plasma circulating VEGF levels were detected in 39 and 38 patients by ELI- SA, respectively. RESULTS: A total of 69% of patients were positive for circulating IgG antibodies against H pylori. cagA-positive H pylori strains were found in 41% of gastric patients. vacA was found in 50% of patients; s1 strains were more highly expressed among vacA-positive patients. The presence of the s1 strain was signifi cantly associ- ated with cagA (P = 0.0001). MVD was signifi cantly cor- related with both tumor VEGF expression (r = 0.361, P = 0.009) and serum VEGF levels (r = -0.347, P = 0.041).Conversely, neither VEGF-R1 expression nor MVD was related to p53 expression. However, H pylori was not related to any angiogenic markers except for the plasma VEGF level (P = 0.026). CONCLUSION: H pylori antigen is related to higher plasma VEGF levels, but not to angiogenic character- istics. It can be hypothesized that the toxic effects of H pylori on angiogenesis occurs in early preclinical dis- ease phase or in long-lasting aggressive infections, but only when high H pylori IgG levels are persistent. | Anita Mangia Annalisa Chiriatti Girolamo Ranieri Ines Abbate Maria Coviello Giovanni Simone Francesco Alfredo Zito Severino Montemurro Antonello Rucci Alfredo Di Leo Stefania Tommasi Pasquale Berloco Jian Ming Xu Angelo Paradiso | 2006 | World Journal of Gastroenterology2006，12，34： | 5 |
| 5 | Functional conservation of the grapevine candidate gene INNER NO OUTER for ovule development and seed formation显示文摘Seedlessness represents a highly appreciated trait in table grapes.Based on an interesting case of seedless fruit production described in the crop species Annona squamosa,we focused on the Vitis vinifera INNER NO OUTER(INO)gene as a candidate.This gene encodes a transcription factor belonging to the YABBY family involved in the determination of abaxial identity in several organs.In Arabidopsis thaliana,this gene was shown to be essential for the formation and asymmetric growth of the ovule outer integument and its mutation leads to a phenotypic defect of ovules and failure in seed formation.In this study,we identified in silico the V.vinifera orthologue and investigated its phylogenetic relationship to INO genes from other species and its expression in different organs in seeded and seedless varieties.Applying cross-species complementation,we have tested its functionality in the Arabidopsis ino-1 mutant.We show that the V.vinifera INO successfully rescues the ovule outer integument growth and seeds set and also partially complements the outer integument asymmetric growth in the Arabidopsis mutant,differently from orthologues from other species.These data demonstrate that VviINO retains similar activity and protein targets in grapevine as in Arabidopsis.Potential implications for grapevine breeding are discussed. | Valentina di Rienzo Zahra Imanifard Isabella Mascio Charles SGasser Debra JSkinner Ciro Leonardo Pierri Martina Marini Valentina Fanelli Wilma Sabetta Cinzia Montemurro Diana Bellin | 2021 | Horticulture Research2021，8，1： | 2 |
| 6 | Dose-dense vinorelbine and paclitaxel with granulocyte colony-stimulating factor in metastatic breast patients:anti-tumor activity and peripheral blood progenitor cell mobilization capability显示文摘 | Ballestrero A Montemurro F Gonella R | 2003 | Breast Cancer Res Treat2003，82，3： | 1 |
| 7 | Prevention of hypertension, cardiovascular damage and endothelial dysfunction with green tea extracts 显示文摘 | Antonello M Montemurro D Bolognesi M | 2007 | American Journal of Hypertension2007，20，12： | 1 |
| 8 | Trastuzum ab:mechanism of action, resistance and Future perspectives in Her-2 overexpressing breast cancer显示文摘 | Valabrega G Montemurro F Aglietta M | 2007 | Ann Oncol2007，18，6： | 1 |
| 9 | Evaluation of the effect of cryopreservation on exvivo expasion of hematopoietic progenitors from cord blood显示文摘 | Lazzari L Lucchi S Montemurro T | 2001 | Bone Marrow Transplant2001，28，7： | 1 |
| 10 | Nilotinib in the treatment of advanced gastrointes-tinal stromal tumours resistant to both imatinib and sunitinib显示文摘 | Montemurro M | 2009 | Eur J Cancer2009，45，13： | 1 |
| 11 | Continuous Sunitinib treatment in patients with advanced hepatocellular carcinoma:a Swiss Group for Clinical Cancer Research (SAKK) and Swiss Association for the Study of the Liver (SASL) multicenter phase Ⅱ trial (SAKK 77/06)显示文摘 | Koeberle D Montemurro M Samaras P | 2010 | Oncologist2010，15，3： | 1 |
| 12 | A rare case of extraadrenal pheochromocytoma masquerading as an ovarian mass treated by laparoscopic surgery 显示文摘 | Montemurro S Ruggieri E Maselli E | 2007 | Eur J Gynaecol Oncoh2007，28，6： | 1 |
| 13 | Prevention and treatment of febrile neutropenia 显示文摘 | MONTEMURRO F GALLICCHID M AGLIETTA M | 1997 | Tumori1997，83，2： | 1 |
| 14 | Immunophenotypic heterogeneity of hyalinzing trabecular tumors of the thyroid显示文摘 | Papotti M Riella P Montemurro F | 1997 | Histopathology1997，31，6： | 1 |
| 15 | Lapatinib: a dual inhibitor of EGFR and HER-2 tyrosine kinase activ- ity 显示文摘 | Montemurro F Valabrega G Aglietta M | 2007 | Expert Opin Biol Ther2007，7，2： | 1 |
| 16 | Our experience of nipple reconstruction using the C-V flap technique: 1 year evaluati- on显示文摘 | Valdatta L Montemurro P Tamborini F | 2009 | J Plast Reconstr Aesthet Surg2009，62，10： | 1 |
| 17 | Selectively enhanced cellular signaling by Gi proteins in essential hypertension: Gi2, Gi3,Gβ1, and Gβ2 are not mutated显示文摘 | Pietruck F Moritz A Montemurro M | 1996 | Circ Res1996，79，： | 1 |
| 18 | Continuous sunitinib treatment in patients with unresectable hepatocellular carcinoma (HCC): A muhicenter phase 11 trial (SAKK 77/06 and SASL 23) 显示文摘 | KOEBERLE D MONTEMURRO M SAMARAS P | 2009 | J Clin 0ncol2009，27，15： | 1 |
| 19 | Long-term effects of organic amendments on soil fertility. A review显示文摘 | Mariangela Diacono Francesco Montemurro | 2009 | Agronomy for Sustainable Development2009，，2： | 1 |
| 20 | Clinical outcome of adjuvant endocrine treatment according to PR and HER2 status in early breast cancer显示文摘 | Ponzone R Montemurro F Maggiorotto F | 2006 | Ann Oncol2006，17，16： | 1 |
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