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| 1 | Aberrant Th2 inflammation drives dysfunction of alveolar macrophages and susceptibility to bacterial pneumonia显示文摘The ubiquitin ligase,Itch,is required to prevent autoinflammatory disease in mice and humans.Itch-deficient mice develop lethal pulmonary inflammation characterized by the production of Th2 cytokines(for example,interleukin-4(IL-4));however,the contribution of Itch to immune defense against respiratory pathogens has not been determined.We found that Itch-deficient mice were highly susceptible to intranasal infection with the respiratory pathogen Klebsiella pneumoniae.Infected Itch-deficient mice exhibited increased immune cell infiltration,cytokine levels and bacterial burden in the respiratory tract compared with control mice.However,numbers of resident alveolar macrophages were reduced in the lungs from Itch-deficient mice both before and after infection.High levels of Th2 cytokines in the respiratory tract correlated with deceased alveolar macrophages,and genetic ablation of IL-4 restored alveolar macrophages and host defense to K.pneumoniae in Itch-deficient mice,suggesting that loss of alveolar macrophages occurred as a consequence of Th2 inflammation.Adoptive transfer of Itch−/−CD4+T cells into Rag−/−mice was sufficient to drive reduction in numbers of Itch-replete alveolar macrophages.Finally,we found that Stat6 signaling downstream of the IL-4 receptor directly reduced fitness of alveolar macrophages when these cells were exposed to the Itch−/−inflamed respiratory tract.These data suggest that Th2 inflammation directly impairs alveolar macrophage fitness in Itch−/−mice,and elucidate a previously unappreciated link between Th2 cells,alveolar macrophages and susceptibility to bacterial infection. | Emily K Moser Natania S Field Paula M Oliver | 2018 | Cellular & Molecular Immunology2018，15，5： | 2 |
| 2 | Products from primary sludge fermentation and their suitability for nutrient removal 显示文摘 | MOSER E R UDERT K M WILD D | 1998 | Wat Sci Tech1998，38，1： | 1 |
| 3 | Phosphoproteomic analysis of rat liver by high capacity IMAC and LC-MS/MS显示文摘 | Moser K White F M | 2006 | J Proteome Res2006，5，1： | 1 |
| 4 | Ecarin clotting time but not APTT correlates with PEG-hirudin plasma activity 显示文摘 | MOSER M RUEF J PETER K | 2001 | J Thromb Thrombolysis2001，12，2： | 1 |
| 5 | Gender diferences in adherence to the sodium-restricted dlet in patients with heart failure显示文摘 | Chung M L Moser D K Lennie T A | 2006 | J Card Fail2006，12，8： | 1 |
| 6 | Archaeal diversity in waters from deep South African gold mines 显示文摘 | Takai K Moser D P DeFlaun M | 2001 | Applied and Environmental Microbiology2001，67，12： | 1 |
| 7 | Persistent comorbid symp- toms of depression and anxiety predict mortality in heart disease显示文摘 | Doering L V Moser D K Riegel B | 2010 | International ioumal of cardiology2010，145，2： | 1 |
| 8 | Dendritic cell regulation of TH1- TH2 development 显示文摘 | Moser M Murphy K M | 2000 | Nat Immun2000，1，： | 1 |
| 9 | Comparison of Ir and Ni-based Ohmic contacts for AlGaN/GaN high electron mobility transistors显示文摘 | FITCH R C GILLESPIE J K MOSER N | 2004 | J Vac Sci Technol2004，22，2： | 1 |
| 10 | Immunological analysis of cloned schistosoma mansoni anti gens Sm31 and Sm32 with sera of schistosomiasis pateints 显示文摘 | Klinkert MQ Bommert K Moser D | 1991 | Trop Med Parasitol1991，42，4： | 1 |
| 11 | Is anxiety early after myocardial infarction associated with subsequent ischemic and arrhythmic events显示文摘 | Moser DK Dracup K | 1996 | Psy- chosom Med1996，58，5： | 1 |
| 12 | Archaeal diversity in waters from deep South African gold mines显示文摘 | TAKAI K MOSER D P DEFLAUN M | 2001 | Appl Environ Microbiol2001，67，12： | 1 |
| 13 | A stable quasi-solid-state dye-sensitized solar cell with an amphiphilic ruthenium sensitizer and polymer gel electrolyte显示文摘 | Wang P Zakeeruddin S M Moser J E Nazeeruddin M K Sekiguchi T Gr(a)tzel M | | 0，，： | 1 |
| 14 | Entwieklung und validierung einer networkingskala显示文摘 | Wolff H G and Moser K | 2006 | Diagnostiea2006，52，4： | 1 |
| 15 | Reduced Leptin levels in starvation increase susceptibility to endotoxic shock显示文摘 | Faggioni R Moser A Feingold K R | 2000 | Am J Pathol2000，156，： | 1 |
| 16 | Causes of delay in seeking treatment for heart attack symptoms显示文摘 | Dracup K Moser DK Eisenberg M | 1995 | Soc Sci Med1995，40，3： | 1 |
| 17 | Drug-resistant pulmonary tuberculosis in the Baja California-San Diego County border population显示文摘 | Peter CR Schultz E Moser K | 1998 | West J Med1998，169，4： | 1 |
| 18 | Dynamic interleaved 1H/31P STEAM MRS at 3 Tesla using a pneumatic force-controlled plantar flexion exercise rig显示文摘 | M. Meyerspeer M. Kr??ák G. J. Kemp M. Roden E. Moser | 2005 | Magnetic Resonance Materials in Physics Biology and Medicine2005，，5： | 1 |
| 19 | A new equivalent reynolds number model for condensation in smooth tubes 显示文摘 | Moser K Webb R L Na B | 1998 | Journal of Iteat Transfer1998，120，2： | 1 |
| 20 | Crosspresenting human gamma delta T cells induce robust CD8+alpha beta T cell responses显示文摘 | Brandes M Willimann K Bioley G Lévy N Eberl M Luo M TampéR Lévy F Romero P Moser B | 2009 | Proc Natl Acad Sci USA2009，106，7： | 1 |
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