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| 1 | Effects of 5-hydroxytamine and its antagonists on hepatic stellate cells显示文摘BACKGROUND: Hepatic stellate cell (HSC) plays a key role in hepatic fibrosis. This study was undertaken to investigate the expression of 5-hydroxytamine receptors in HSC and the effect of 5-hydroxytamine on biological characteristics of HSC. METHODS: Liver ex vivo perfusion of collagenase and density gradient centrifugation were used to isolate HSCs. Reverse transcriptase polymerase chain reaction (RT-PCR) was used to detect the expression of 5-hydroxytamine receptor subtypes 1A, 2A, 2B and 3. Western blot hybridization was used to elucidate the effect of 5-hydroxytamine and its 2A receptor antagonist ketanserin and 3 receptor antagonist ondanosetron on the expression of transforming growth factor-β1(TGF-β1) and Smad4 in HSC. RESULTS: HSC expressed 5-hydroxytamine receptor subtypes 1A, 2A and 2B. 5-hydroxytamine significantly increased the expression of TGF-β1, and Smad4 in HSC (P<0.05). This action can be antagonized by ketanserin, not by ondanosetron. CONCLUSIONS: HSC expresses 5-hydroxytamine receptors. 5-hydroxytamine could effect the biological characteristics of HSC through its receptor mediation, and may play a role in the pathogenesis of liver cirrhosis and portal hypertension. | Tao Li, Shan-Geng Weng, Xi-Sheng Leng, Ji-Run Peng, Yu-Hua Wei, Dong-Cheng Mou and Wan-Xiang Wang Department of Hepatobiliary Surgery, Peking University People’s Hospital, Beijing 100044, China | 2006 | Hepatobiliary & Pancreatic Diseases International2006，5，1： | 7 |
| 2 | Binding pancreaticojejunostomy is a new technique to minimize leakage显示文摘 | Peng S Mou Y Cai X | 2002 | Am J Surg2002，183，： | 1 |
| 3 | A small asparagine-rich protein required for S-allele-specific pollen rejection in Nicotiana显示文摘 | McClure B A Mou B Canevascini S | 1999 | Proc Natl Acad Sci USA1999，96，13： | 1 |
| 4 | Comparing conventional gauze therapy to vacuum-assisted closure wound therapy:aprospective randomized trial显示文摘 | Mous CM van den Bemd GJ Heule F | 2007 | J Plast Reconstr Aesthet Surg2007，60，6： | 1 |
| 5 | Tubular MCM-41-supported transition metal oxide catalysts for ethylbenzene dehydrogenation reaction显示文摘 | Wong S T Lin H P Mou C Y | 2000 | Applied Catalysis A:General2000，198，： | 1 |
| 6 | Binding pancreaticojejunostomy is a new technique to minimize leakage显示文摘 | Peng S Y Mou Y Cai X | 2002 | Am J Surg2002，183，3： | 1 |
| 7 | Binding pancreaticojejunostomy is a Dew techniqueto minimize leakage 显示文摘 | Peng S Mou Y Cai X | 2002 | Am J Surg2002，183，3： | 1 |
| 8 | (VO)2+ Ions immobilized on functionalized surface of mesoporous silica and their activity to- ward the hydroxylation of benzene显示文摘 | Lee C H Lin T S Mou C Y | 2003 | J Phys Chem B2003，107，11： | 1 |
| 9 | Organic gels are useful as a template for the preparation of hollow fiber silica 显示文摘 | Lin H P Mou C Y Liu S B | 2000 | Adv Mater2000，2，： | 1 |
| 10 | A k-earrageenan derived oli- gosaecharide prepared by enzymatie degradation containing antitu- mor aetivity显示文摘 | MOU H J JIANG X L GUAN H S | 2003 | Journal of Applied Phycology2003，15，4： | 1 |
| 11 | On the security of a chaotic encryption scheme:Problems with computerized chaos in finite computing precision显示文摘 | LI S J MOU X Q CAI Y L | 2003 | Computer Physics Communications2003，153，1： | 1 |
| 12 | Src homology 2-containing phosphotyrosine phosphatase regulates endothelin-1-induced epidermal growth factor receptor transactivation in rat renal tubular cell NRK-52E显示文摘 | CHENG HSIEN C YUNG HO H YUH MOU S | 2006 | Pflugers Arch2006，452，1： | 1 |
| 13 | Mesoporous materials for encapsulating enzymes 显示文摘 | Lee C H Lin T S Mou C Y | 2009 | Nano Today2009，4，2： | 1 |
| 14 | Separation and determination of four artificial sweeteners and citric acid by high - performance anion - exchange chromatography 显示文摘 | CHEN Q c MOU S F LIU K N | 1997 | J Chromatography A1997，771，1： | 1 |
| 15 | The role of topical negative pressure in wound repair:expression of biochemical markers in wound fluid during wound healing显示文摘 | Mou(e)s CM van Toorenenbergen AW Heule F | 2008 | Wound Repair Regen2008，16，4： | 1 |
| 16 | Preparation and blood compatibility of polysiloxane/liquid-crystal composite membranes显示文摘 | Li L H Tu M Mou S | | 0，，10： | 1 |
| 17 | Improving security of a chaotic encryption approach显示文摘 | LI S J MOU X Q CAI Y L | 2001 | Physics Letters A2001，290，4： | 1 |
| 18 | Synthesis of mesoporous silicananoparticles 显示文摘 | WU S H MOU C Y LIN H P | 2013 | Chem Soc Rev2013，42，9： | 1 |
| 19 | Mesoporous silica nanoparticles as nanocarriers显示文摘 | Wu S H Hung Y Mou C Y | 2011 | Chem Commun2011，47，36： | 1 |
| 20 | Binding pancreaticojejunostomy is a new technique to minimize leakage显示文摘 | Peng S Mou Y Cai X | 2002 | Am J Surg2002，183，28： | 1 |
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