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| 1 | Relationship between serum b2-microglobulin levels and virological breakthrough in HBeAg-negative chronic hepatitis B patients,under long-term treatment schedules including lamivudine显示文摘AIM: Predictive value of serum b2-microglobulin (b2m)levels for virological breakthrough (VB) in HBeAg-negative chronic hepatitis B (CHB) patients under long-term treatment schedules including lamivudine (LAM).METHODS: Serum b2m levels were calculated during treatment in 25 CHB patients under long-term LAM monotherapy (group A) and 12 patients under initial interferon plus LAM treatment followed by LAM monotherapy (group B), using the MEIA technology. We used Cox proportional hazard models in order to investigate the association between serum b2m levels and VB.RESULTS: Seven of 25 patients (28%), 9/25 (36%) and 14/25 (56%) from group A and 0/12, 2/12 (16.6%) and 3/12 (25%) from group B exhibited VB at months 12, 24 and 36 of treatment, respectively. All patients, from both groups, who did not show VB exhibited b2m elevation in mo 3. The duration of b2m elevation was significantly longer in the virological responder's subgroup from group A than the non-responder's one (7.3±2.6 vs 3.8±3.4 mo,P = 0.02). In comparison to group A patients whose b2m levels were increased at 3 mo, patients whose b2m levels were decreased had 4.6 times higher risk of experiencing VB (RR = 4.6, P = 0.024). When baseline variables were simultaneously included in the same Cox model, decreased b2m status was still associated with increased risk of VB (RR = 12.2, P = 0.03).CONCLUSION: In HBeAg-negative CHB patients under either long-term LAM monotherapy or initial combination treatment, serum b2m levels at 3 mo of treatment,compared to baseline ones, might be a predictor of risk for VB. | Ioannis S.Elefsiniotis Antonios Moulakakis Konstantinos D.Pantazis Irene Glynou Ioannis Ketikoglou Elena Vezali Helen Kada Epameinondas Tsianos | 2005 | World Journal of Gastroenterology2005，11，13： | 4 |
| 2 | The chimney graft technique for preserving visceral vessels during endovascular treatment of aortic pathologies显示文摘 | Konstantinos G. Moulakakis Spyridon N. Mylonas Efthimios Avgerinos Anastasios Papapetrou John D. Kakisis Elias N. Brountzos Christos D. Liapis | 2012 | Journal of Vascular Surgery2012，，5： | 2 |
| 3 | Hyperper-fusion syndrome after carotid revascularization 显示文摘 | Moulakakis KG Mylonas SN Sfyroeras GS | 2009 | J VaseSurg2009，49，： | 1 |
| 4 | A- cute mesenteric ischaemia, a highly lethal disease with a devastating outcome 显示文摘 | Safioleas MC Moulakakis KG Papavassiliou VG | 2006 | Vasa2006，35，2： | 1 |
| 5 | Role of clathrin - mediated endocytosis of surfactant protein A by alveolar macrophages in intracellular signaling 显示文摘 | Moulakakis C Stamme C | 2009 | Am J Physiol Lung Cell Mol Physiol2009，296，3： | 1 |
| 6 | Acute mes2enteric ischaemia, a highly lethal disease with a devastating outcome显示文摘 | SafioleasMC Moulakakis KG Papavassiliou VG | 2006 | Vasa2006，35，10： | 1 |
| 7 | Stapled chole- cystojejunostomy for palliative Ireatment of the malignant jaundice; an effective and feasible alterntive to hand-sewn method显示文摘 | Safioleas MC Moulakakis KG Safioleas CM | 2010 | Int ISurg2010，8，6： | 1 |
| 8 | Acute mesenteric ischaemia,a highly lethal disease with a devastating outcome显示文摘 | Safioleas MC Moulakakis KG Papavassiliou VG | | 0，，02： | 1 |
| 9 | The role of soluble P selectin in the diagnosis of venous thromboembolism显示文摘 | Constantine N. Antonopoulos George S. Sfyroeras John D. Kakisis Konstantinos G. Moulakakis Christos D. Liapis | 2014 | Thrombosis Research2014，，1： | 1 |
| 10 | Hyperperfusion syndrome after carotid revascularization 显示文摘 | Moulakakis KG Mylonas SN Sfyroeras GS | 2009 | J Vase Surg2009，49，4： | 1 |
| 11 | Retrograde transpopliteal approach of iliofemoral lesions 显示文摘 | Brountzos EN Moulakakis KG Avgerinos ED | 2011 | Vase Endovascular Surg2011，45，7： | 1 |
| 12 | The chimney graft technique for preserving visceral vessels during endovaseular treatment of aortic pathologies显示文摘 | Moulakakis KG Mylonas SN Avgerinos E | | 0，，： | 1 |
| 13 | Correlation between lipid abnormalities and immunosuppressive therapy in renal transplant recipients with stable renal function显示文摘 | Perrea DN Moulakakis KG Poulakou MV | 2008 | Int Urol Nephrol2008，40，2： | 1 |
| 14 | The chimney - graft technique for preserving supra - aortic branches: A review 显示文摘 | Moulakakis KG Mylonas SN Dalainas I | 2013 | Ann Cardiothorae Surg2013，2，3： | 1 |
| 15 | Volume of new-onset thrombus is associated with the development of postimplantation syndrome after endovascular aneurysm repair 显示文摘 | Kakisis JD Moulakakis KG Antonopoulos CN | 2014 | J VascSurg2014，60，5： | 1 |
| 16 | Hyperperfusion syndrome after carotid revascularization显示文摘 | Moulakakis KG Mylonas SN Sfyroeras GS | | 0，，4： | 1 |
| 17 | The chimney graft technique for preserving visceral vessels during endovascular treatment of aortic pathologies显示文摘 | Moulakakis KG Mylonas SN Avgerinos E | 2012 | J Vase Surg2012，55，5： | 1 |
| 18 | The chinmey- graft technique for preserving supra-aortic branches: a review显示文摘 | Moulakakis KG Mylonas SN Dalainas I | 2013 | Annals of Cardiothoracic Surgery2013，2，3： | 1 |
| 19 | Acute rues- enteric ischaemia, a highly lethal disease with a devastating outcome显示文摘 | Safioleas MC Moulakakis KG Papavassiliou VG | 2006 | Vasa2006，35，2： | 1 |
| 20 | Correlation between lipid abnormalities and immunosuppressive therapy in renal transplant recipients with stable renal function显示文摘 | Perrea DN Moulakakis KG Poulakou MV | 2008 | Int Urol Nephrol2008，40，2： | 1 |
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